Neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study

Laisheng Cai, Jingwei Huang Department of Neurology, The First Affiliated Hospital of Nanchang University, Jiangxi, People’s Republic of China Purpose: There is a need for biomarkers in multiple sclerosis (MS) to make an early diagnosis and monitor its progression. This study was designe...

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Autores principales:	Cai L, Huang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Multiple sclerosis，neurofilament light chain，meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/cbdf575a7903489f85725f8051f941ae
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spelling	oai:doaj.org-article:cbdf575a7903489f85725f8051f941ae2021-12-02T07:50:54ZNeurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study1178-2021https://doaj.org/article/cbdf575a7903489f85725f8051f941ae2018-09-01T00:00:00Zhttps://www.dovepress.com/neurofilament-light-chain-as-a-biological-marker-for-multiple-sclerosi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Laisheng Cai, Jingwei Huang Department of Neurology, The First Affiliated Hospital of Nanchang University, Jiangxi, People’s Republic of China Purpose: There is a need for biomarkers in multiple sclerosis (MS) to make an early diagnosis and monitor its progression. This study was designed to evaluate the value of neurofilament light (NFL) chain levels as cerebrospinal fluid (CSF) or blood biomarker in patients with MS by using a quantitative meta-analysis. Methods: The PubMed, Embase, and Web of Science databases were systematically searched for relevant studies. Articles in English that evaluated the utility of NFL in CSF and blood in the diagnosis of MS were included. Data were extracted by two independent researchers. Mean (± SD) NFL concentration for MS patients and control subjects were extracted. Review Manager version 5.3 software with a continuous-variable random-effects model was used to summarize the diagnostic indexes from eligible studies. The Newcastle–Ottawa Scale was used for assessing the quality and risk of bias of included studies. In addition, subgroup analysis and meta-regression were performed to assess potential heterogeneity sources. Results: The meta-analysis included 13 articles containing results from 15 studies. A total of 10 studies measured NFL levels in CSF and five studies measured NFL levels in blood. Data were available on 795 participants in CSF and 1,856 participants in blood. Moreover, CSF NFL in MS patients was higher than that in healthy control groups (pooled standard mean difference [Std.MD]=0.88, 95% CI [0.50, 1.26], P<0.00001) and serum NFL in MS patients was higher than that in control subjects (pooled Std.MD=0.47, 95% CI [0.24, 0.71], P<0.0001). Conclusion: NFL chain has significantly increased in MS patients, which substantially strengthens the clinical evidence of the NFL in MS. The NFL may be used as a prognostic biomarker to monitor disease progression, disease activity, and treatment efficacy in the future. Keywords: multiple sclerosis, neurofilament light chain, meta-analysisCai LHuang JDove Medical PressarticleMultiple sclerosis，neurofilament light chain，meta-analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2241-2254 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multiple sclerosis，neurofilament light chain，meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Multiple sclerosis，neurofilament light chain，meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Cai L Huang J Neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study
description	Laisheng Cai, Jingwei Huang Department of Neurology, The First Affiliated Hospital of Nanchang University, Jiangxi, People’s Republic of China Purpose: There is a need for biomarkers in multiple sclerosis (MS) to make an early diagnosis and monitor its progression. This study was designed to evaluate the value of neurofilament light (NFL) chain levels as cerebrospinal fluid (CSF) or blood biomarker in patients with MS by using a quantitative meta-analysis. Methods: The PubMed, Embase, and Web of Science databases were systematically searched for relevant studies. Articles in English that evaluated the utility of NFL in CSF and blood in the diagnosis of MS were included. Data were extracted by two independent researchers. Mean (± SD) NFL concentration for MS patients and control subjects were extracted. Review Manager version 5.3 software with a continuous-variable random-effects model was used to summarize the diagnostic indexes from eligible studies. The Newcastle–Ottawa Scale was used for assessing the quality and risk of bias of included studies. In addition, subgroup analysis and meta-regression were performed to assess potential heterogeneity sources. Results: The meta-analysis included 13 articles containing results from 15 studies. A total of 10 studies measured NFL levels in CSF and five studies measured NFL levels in blood. Data were available on 795 participants in CSF and 1,856 participants in blood. Moreover, CSF NFL in MS patients was higher than that in healthy control groups (pooled standard mean difference [Std.MD]=0.88, 95% CI [0.50, 1.26], P<0.00001) and serum NFL in MS patients was higher than that in control subjects (pooled Std.MD=0.47, 95% CI [0.24, 0.71], P<0.0001). Conclusion: NFL chain has significantly increased in MS patients, which substantially strengthens the clinical evidence of the NFL in MS. The NFL may be used as a prognostic biomarker to monitor disease progression, disease activity, and treatment efficacy in the future. Keywords: multiple sclerosis, neurofilament light chain, meta-analysis
format	article
author	Cai L Huang J
author_facet	Cai L Huang J
author_sort	Cai L
title	Neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study
title_short	Neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study
title_full	Neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study
title_fullStr	Neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study
title_full_unstemmed	Neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study
title_sort	neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/cbdf575a7903489f85725f8051f941ae
work_keys_str_mv	AT cail neurofilamentlightchainasabiologicalmarkerformultiplesclerosisametaanalysisstudy AT huangj neurofilamentlightchainasabiologicalmarkerformultiplesclerosisametaanalysisstudy
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Neurofilament light chain as a biological marker for multiple sclerosis: a meta-analysis study

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