Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
The severity of ulcerative colitis, and response to treatment, is highly variable. Here, the authors examine rectal gene expression signatures and faecal microbiomes of children and adults with the disease and provide new insights in to pathogenesis.
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Nature Portfolio
2019
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oai:doaj.org-article:cbe3d637f8854aa08026fcc4f3d0a9e72021-12-02T14:39:21ZUlcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response10.1038/s41467-018-07841-32041-1723https://doaj.org/article/cbe3d637f8854aa08026fcc4f3d0a9e72019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07841-3https://doaj.org/toc/2041-1723The severity of ulcerative colitis, and response to treatment, is highly variable. Here, the authors examine rectal gene expression signatures and faecal microbiomes of children and adults with the disease and provide new insights in to pathogenesis.Yael HabermanRebekah KarnsPhillip J. DexheimerMelanie SchirmerJudith SomekhIngrid JurickovaTzipi BraunElizabeth NovakLaura BaumanMargaret H. CollinsAngela MoMichael J. RosenErin BonkowskiNathan GotmanAlison MarquisMason NistelPaul A. RufoSusan S. BakerCary G. SauerJames MarkowitzMarian D. PfefferkornJoel R. RoshBrendan M. BoyleDavid R. MackRobert N. BaldassanoSapana ShahNeal S. LeleikoMelvin B. HeymanAnne M. GrifithsAshish S. PatelJoshua D. NoeBruce J. AronowSubra KugathasanThomas D. WaltersGreg GibsonSonia Davis ThomasKevin MollenShai Shen-OrrCurtis HuttenhowerRamnik J. XavierJeffrey S. HyamsLee A. DensonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q Yael Haberman Rebekah Karns Phillip J. Dexheimer Melanie Schirmer Judith Somekh Ingrid Jurickova Tzipi Braun Elizabeth Novak Laura Bauman Margaret H. Collins Angela Mo Michael J. Rosen Erin Bonkowski Nathan Gotman Alison Marquis Mason Nistel Paul A. Rufo Susan S. Baker Cary G. Sauer James Markowitz Marian D. Pfefferkorn Joel R. Rosh Brendan M. Boyle David R. Mack Robert N. Baldassano Sapana Shah Neal S. Leleiko Melvin B. Heyman Anne M. Grifiths Ashish S. Patel Joshua D. Noe Bruce J. Aronow Subra Kugathasan Thomas D. Walters Greg Gibson Sonia Davis Thomas Kevin Mollen Shai Shen-Orr Curtis Huttenhower Ramnik J. Xavier Jeffrey S. Hyams Lee A. Denson Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response |
| description |
The severity of ulcerative colitis, and response to treatment, is highly variable. Here, the authors examine rectal gene expression signatures and faecal microbiomes of children and adults with the disease and provide new insights in to pathogenesis. |
| format |
article |
| author |
Yael Haberman Rebekah Karns Phillip J. Dexheimer Melanie Schirmer Judith Somekh Ingrid Jurickova Tzipi Braun Elizabeth Novak Laura Bauman Margaret H. Collins Angela Mo Michael J. Rosen Erin Bonkowski Nathan Gotman Alison Marquis Mason Nistel Paul A. Rufo Susan S. Baker Cary G. Sauer James Markowitz Marian D. Pfefferkorn Joel R. Rosh Brendan M. Boyle David R. Mack Robert N. Baldassano Sapana Shah Neal S. Leleiko Melvin B. Heyman Anne M. Grifiths Ashish S. Patel Joshua D. Noe Bruce J. Aronow Subra Kugathasan Thomas D. Walters Greg Gibson Sonia Davis Thomas Kevin Mollen Shai Shen-Orr Curtis Huttenhower Ramnik J. Xavier Jeffrey S. Hyams Lee A. Denson |
| author_facet |
Yael Haberman Rebekah Karns Phillip J. Dexheimer Melanie Schirmer Judith Somekh Ingrid Jurickova Tzipi Braun Elizabeth Novak Laura Bauman Margaret H. Collins Angela Mo Michael J. Rosen Erin Bonkowski Nathan Gotman Alison Marquis Mason Nistel Paul A. Rufo Susan S. Baker Cary G. Sauer James Markowitz Marian D. Pfefferkorn Joel R. Rosh Brendan M. Boyle David R. Mack Robert N. Baldassano Sapana Shah Neal S. Leleiko Melvin B. Heyman Anne M. Grifiths Ashish S. Patel Joshua D. Noe Bruce J. Aronow Subra Kugathasan Thomas D. Walters Greg Gibson Sonia Davis Thomas Kevin Mollen Shai Shen-Orr Curtis Huttenhower Ramnik J. Xavier Jeffrey S. Hyams Lee A. Denson |
| author_sort |
Yael Haberman |
| title |
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response |
| title_short |
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response |
| title_full |
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response |
| title_fullStr |
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response |
| title_full_unstemmed |
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response |
| title_sort |
ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/cbe3d637f8854aa08026fcc4f3d0a9e7 |
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