Dietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn’s disease: a pilot study

Abstract Background The anti-inflammatory effect of exclusive enteral nutrition on the gut of children with Crohn’s disease is rapidly lost after food reintroduction. This study assessed disease dietary triggers following successful treatment with exclusive enteral nutrition. Methods Nutrient intake...

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Autores principales:	Konstantinos Gkikas, Michael Logan, Ben Nichols, Umer Z. Ijaz, Clare M. Clark, Vaios Svolos, Lisa Gervais, Hazel Duncan, Vikki Garrick, Lee Curtis, Elaine Buchanan, Tracey Cardigan, Lawrence Armstrong, Caroline Delahunty, Diana M. Flynn, Andrew R. Barclay, Rachel Tayler, Simon Milling, Richard Hansen, Richard K. Russell, Konstantinos Gerasimidis
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Crohn’s disease Food reintroduction Dietary triggers Faecal calprotectin Gluten Fibre Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/cbe50ab996a24cd59fa8aacddecc3c19
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spelling	oai:doaj.org-article:cbe50ab996a24cd59fa8aacddecc3c192021-12-05T12:11:02ZDietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn’s disease: a pilot study10.1186/s12876-021-02029-41471-230Xhttps://doaj.org/article/cbe50ab996a24cd59fa8aacddecc3c192021-12-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02029-4https://doaj.org/toc/1471-230XAbstract Background The anti-inflammatory effect of exclusive enteral nutrition on the gut of children with Crohn’s disease is rapidly lost after food reintroduction. This study assessed disease dietary triggers following successful treatment with exclusive enteral nutrition. Methods Nutrient intake, dietary patterns and dietary biomarkers in faeces (gluten immunogenic peptides, undigestible starch, short chain fatty acids) were assessed in 14 children with Crohn’s disease during early food reintroduction, following exclusive enteral nutrition. Groups above (Group A) and below (Group B) the median levels of faecal calprotectin after food reintroduction were assigned for comparative analysis. Results Intakes of fibre, gluten-containing cereals and red and processed meat were significantly higher in Group A than Group B; (median [Q1, Q3], g/day; Fibre: 12.1 [11.2, 19.9] vs. 9.9 [7.6, 12.1], p = 0.03; Red and processed meat: 151 [66.7, 190] vs. 63.3 [21.7, 67], p = 0.02; gluten-containing cereals: 289 [207, 402] vs. 203 [61, 232], p = 0.035). A diet consisting of cereals and meat products was predictive (92% accuracy) of higher faecal calprotectin levels after food reintroduction. In faeces, butyrate levels, expressed as absolute concentration and relative abundance, were higher in Group A than Group B by 28.4 µmol/g (p = 0.015) and 6.4% (p = 0.008), respectively. Levels of gluten immunogenic peptide and starch in faeces did not differ between the two groups. Conclusions This pilot study identified potential dietary triggers of gut inflammation in children with Crohn’s disease after food reintroduction following treatment with exclusive enteral nutrition. Trial registration: Clinical trials.gov registration number: NCT02341248; Clinical trials.gov URL: https://clinicaltrials.gov/ct2/show/NCT02341248 (retrospectively registered).Konstantinos GkikasMichael LoganBen NicholsUmer Z. IjazClare M. ClarkVaios SvolosLisa GervaisHazel DuncanVikki GarrickLee CurtisElaine BuchananTracey CardiganLawrence ArmstrongCaroline DelahuntyDiana M. FlynnAndrew R. BarclayRachel TaylerSimon MillingRichard HansenRichard K. RussellKonstantinos GerasimidisBMCarticleCrohn’s diseaseFood reintroductionDietary triggersFaecal calprotectinGlutenFibreDiseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Crohn’s disease Food reintroduction Dietary triggers Faecal calprotectin Gluten Fibre Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Crohn’s disease Food reintroduction Dietary triggers Faecal calprotectin Gluten Fibre Diseases of the digestive system. Gastroenterology RC799-869 Konstantinos Gkikas Michael Logan Ben Nichols Umer Z. Ijaz Clare M. Clark Vaios Svolos Lisa Gervais Hazel Duncan Vikki Garrick Lee Curtis Elaine Buchanan Tracey Cardigan Lawrence Armstrong Caroline Delahunty Diana M. Flynn Andrew R. Barclay Rachel Tayler Simon Milling Richard Hansen Richard K. Russell Konstantinos Gerasimidis Dietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn’s disease: a pilot study
description	Abstract Background The anti-inflammatory effect of exclusive enteral nutrition on the gut of children with Crohn’s disease is rapidly lost after food reintroduction. This study assessed disease dietary triggers following successful treatment with exclusive enteral nutrition. Methods Nutrient intake, dietary patterns and dietary biomarkers in faeces (gluten immunogenic peptides, undigestible starch, short chain fatty acids) were assessed in 14 children with Crohn’s disease during early food reintroduction, following exclusive enteral nutrition. Groups above (Group A) and below (Group B) the median levels of faecal calprotectin after food reintroduction were assigned for comparative analysis. Results Intakes of fibre, gluten-containing cereals and red and processed meat were significantly higher in Group A than Group B; (median [Q1, Q3], g/day; Fibre: 12.1 [11.2, 19.9] vs. 9.9 [7.6, 12.1], p = 0.03; Red and processed meat: 151 [66.7, 190] vs. 63.3 [21.7, 67], p = 0.02; gluten-containing cereals: 289 [207, 402] vs. 203 [61, 232], p = 0.035). A diet consisting of cereals and meat products was predictive (92% accuracy) of higher faecal calprotectin levels after food reintroduction. In faeces, butyrate levels, expressed as absolute concentration and relative abundance, were higher in Group A than Group B by 28.4 µmol/g (p = 0.015) and 6.4% (p = 0.008), respectively. Levels of gluten immunogenic peptide and starch in faeces did not differ between the two groups. Conclusions This pilot study identified potential dietary triggers of gut inflammation in children with Crohn’s disease after food reintroduction following treatment with exclusive enteral nutrition. Trial registration: Clinical trials.gov registration number: NCT02341248; Clinical trials.gov URL: https://clinicaltrials.gov/ct2/show/NCT02341248 (retrospectively registered).
format	article
author	Konstantinos Gkikas Michael Logan Ben Nichols Umer Z. Ijaz Clare M. Clark Vaios Svolos Lisa Gervais Hazel Duncan Vikki Garrick Lee Curtis Elaine Buchanan Tracey Cardigan Lawrence Armstrong Caroline Delahunty Diana M. Flynn Andrew R. Barclay Rachel Tayler Simon Milling Richard Hansen Richard K. Russell Konstantinos Gerasimidis
author_facet	Konstantinos Gkikas Michael Logan Ben Nichols Umer Z. Ijaz Clare M. Clark Vaios Svolos Lisa Gervais Hazel Duncan Vikki Garrick Lee Curtis Elaine Buchanan Tracey Cardigan Lawrence Armstrong Caroline Delahunty Diana M. Flynn Andrew R. Barclay Rachel Tayler Simon Milling Richard Hansen Richard K. Russell Konstantinos Gerasimidis
author_sort	Konstantinos Gkikas
title	Dietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn’s disease: a pilot study
title_short	Dietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn’s disease: a pilot study
title_full	Dietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn’s disease: a pilot study
title_fullStr	Dietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn’s disease: a pilot study
title_full_unstemmed	Dietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn’s disease: a pilot study
title_sort	dietary triggers of gut inflammation following exclusive enteral nutrition in children with crohn’s disease: a pilot study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/cbe50ab996a24cd59fa8aacddecc3c19
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Dietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn’s disease: a pilot study

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