Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study

The microbiome plays diverse roles in many diseases and can potentially contribute to cancer development. Breast cancer is the most commonly diagnosed cancer in women worldwide. Thus, we investigated whether the gut microbiota differs between patients with breast carcinoma and those with benign tumo...

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Autores principales:	Peidong Yang, Zhitang Wang, Qingqin Peng, Weibin Lian, Debo Chen
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Evolution QH359-425
Acceso en línea:	https://doaj.org/article/cbe56b5cd20d471db7ce8895711a7753
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spelling	oai:doaj.org-article:cbe56b5cd20d471db7ce8895711a77532021-11-15T04:33:29ZComparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study1176-934310.1177/11769343211057573https://doaj.org/article/cbe56b5cd20d471db7ce8895711a77532021-11-01T00:00:00Zhttps://doi.org/10.1177/11769343211057573https://doaj.org/toc/1176-9343The microbiome plays diverse roles in many diseases and can potentially contribute to cancer development. Breast cancer is the most commonly diagnosed cancer in women worldwide. Thus, we investigated whether the gut microbiota differs between patients with breast carcinoma and those with benign tumors. The DNA of the fecal microbiota community was detected by Illumina sequencing and the taxonomy of 16S rRNA genes. The α-diversity and β-diversity analyses were used to determine richness and evenness of the gut microbiota. Gene function prediction of the microbiota in patients with benign and malignant carcinoma was performed using PICRUSt. There was no significant difference in the α-diversity between patients with benign and malignant tumors ( P = 3.15e −1 for the Chao index and P = 3.1e −1 for the ACE index). The microbiota composition was different between the 2 groups, although no statistical difference was observed in β-diversity. Of the 31 different genera compared between the 2 groups, level of only Citrobacter was significantly higher in the malignant tumor group than that in benign tumor group. The metabolic pathways of the gut microbiome in the malignant tumor group were significantly different from those in benign tumor group. Furthermore, the study establishes the distinct richness of the gut microbiome in patients with breast cancer with different clinicopathological factors, including ER, PR, Ki-67 level, Her2 status, and tumor grade. These findings suggest that the gut microbiome may be useful for the diagnosis and treatment of malignant breast carcinoma.Peidong YangZhitang WangQingqin PengWeibin LianDebo ChenSAGE PublishingarticleEvolutionQH359-425ENEvolutionary Bioinformatics, Vol 17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Evolution QH359-425
spellingShingle	Evolution QH359-425 Peidong Yang Zhitang Wang Qingqin Peng Weibin Lian Debo Chen Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study
description	The microbiome plays diverse roles in many diseases and can potentially contribute to cancer development. Breast cancer is the most commonly diagnosed cancer in women worldwide. Thus, we investigated whether the gut microbiota differs between patients with breast carcinoma and those with benign tumors. The DNA of the fecal microbiota community was detected by Illumina sequencing and the taxonomy of 16S rRNA genes. The α-diversity and β-diversity analyses were used to determine richness and evenness of the gut microbiota. Gene function prediction of the microbiota in patients with benign and malignant carcinoma was performed using PICRUSt. There was no significant difference in the α-diversity between patients with benign and malignant tumors ( P = 3.15e −1 for the Chao index and P = 3.1e −1 for the ACE index). The microbiota composition was different between the 2 groups, although no statistical difference was observed in β-diversity. Of the 31 different genera compared between the 2 groups, level of only Citrobacter was significantly higher in the malignant tumor group than that in benign tumor group. The metabolic pathways of the gut microbiome in the malignant tumor group were significantly different from those in benign tumor group. Furthermore, the study establishes the distinct richness of the gut microbiome in patients with breast cancer with different clinicopathological factors, including ER, PR, Ki-67 level, Her2 status, and tumor grade. These findings suggest that the gut microbiome may be useful for the diagnosis and treatment of malignant breast carcinoma.
format	article
author	Peidong Yang Zhitang Wang Qingqin Peng Weibin Lian Debo Chen
author_facet	Peidong Yang Zhitang Wang Qingqin Peng Weibin Lian Debo Chen
author_sort	Peidong Yang
title	Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study
title_short	Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study
title_full	Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study
title_fullStr	Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study
title_full_unstemmed	Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study
title_sort	comparison of the gut microbiota in patients with benign and malignant breast tumors: a pilot study
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/cbe56b5cd20d471db7ce8895711a7753
work_keys_str_mv	AT peidongyang comparisonofthegutmicrobiotainpatientswithbenignandmalignantbreasttumorsapilotstudy AT zhitangwang comparisonofthegutmicrobiotainpatientswithbenignandmalignantbreasttumorsapilotstudy AT qingqinpeng comparisonofthegutmicrobiotainpatientswithbenignandmalignantbreasttumorsapilotstudy AT weibinlian comparisonofthegutmicrobiotainpatientswithbenignandmalignantbreasttumorsapilotstudy AT debochen comparisonofthegutmicrobiotainpatientswithbenignandmalignantbreasttumorsapilotstudy
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Comparison of the Gut Microbiota in Patients with Benign and Malignant Breast Tumors: A Pilot Study

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