The ribosome modulates folding inside the ribosomal exit tunnel

The ribosome modulates folding inside the ribosomal exit tunnel

Wruck et al. investigate the folding of the small zinc-finger domain ADR1a inside and at the vestibule of the ribosomal tunnel, using optical tweezers, single-molecule FRET, and molecular dynamics simulations. They find that the ribosomal tunnel accelerates folding while stabilizing the folded state...

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Autores principales: Florian Wruck, Pengfei Tian, Renuka Kudva, Robert B. Best, Gunnar von Heijne, Sander J. Tans, Alexandros Katranidis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/cbe82a426918461f8b87118d1e3aba21
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spelling oai:doaj.org-article:cbe82a426918461f8b87118d1e3aba212021-12-02T16:51:49ZThe ribosome modulates folding inside the ribosomal exit tunnel10.1038/s42003-021-02055-82399-3642https://doaj.org/article/cbe82a426918461f8b87118d1e3aba212021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02055-8https://doaj.org/toc/2399-3642Wruck et al. investigate the folding of the small zinc-finger domain ADR1a inside and at the vestibule of the ribosomal tunnel, using optical tweezers, single-molecule FRET, and molecular dynamics simulations. They find that the ribosomal tunnel accelerates folding while stabilizing the folded state like chaperonins. This study provides insights into the role of the ribosomal tunnel in the folding dynamics of nascent polypeptides.Florian WruckPengfei TianRenuka KudvaRobert B. BestGunnar von HeijneSander J. TansAlexandros KatranidisNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Florian Wruck
Pengfei Tian
Renuka Kudva
Robert B. Best
Gunnar von Heijne
Sander J. Tans
Alexandros Katranidis
The ribosome modulates folding inside the ribosomal exit tunnel
description Wruck et al. investigate the folding of the small zinc-finger domain ADR1a inside and at the vestibule of the ribosomal tunnel, using optical tweezers, single-molecule FRET, and molecular dynamics simulations. They find that the ribosomal tunnel accelerates folding while stabilizing the folded state like chaperonins. This study provides insights into the role of the ribosomal tunnel in the folding dynamics of nascent polypeptides.
format article
author Florian Wruck
Pengfei Tian
Renuka Kudva
Robert B. Best
Gunnar von Heijne
Sander J. Tans
Alexandros Katranidis
author_facet Florian Wruck
Pengfei Tian
Renuka Kudva
Robert B. Best
Gunnar von Heijne
Sander J. Tans
Alexandros Katranidis
author_sort Florian Wruck
title The ribosome modulates folding inside the ribosomal exit tunnel
title_short The ribosome modulates folding inside the ribosomal exit tunnel
title_full The ribosome modulates folding inside the ribosomal exit tunnel
title_fullStr The ribosome modulates folding inside the ribosomal exit tunnel
title_full_unstemmed The ribosome modulates folding inside the ribosomal exit tunnel
title_sort ribosome modulates folding inside the ribosomal exit tunnel
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/cbe82a426918461f8b87118d1e3aba21
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