The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense

Background: The weight of evidence suggests that sleep is essential for the processes of memory consolidation and sleep deprivation (SD) impairs the retention of long-term memory in both humans and experimental animals, which is associated with oxidative stress damage within the brain. Green tea pol...

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Autores principales:	Fatemeh Forouzanfar, Jamileh Gholami, Maryam Foroughnia, Bahareh Payvar, Saeideh Nemati, Mohammad Amin Khodadadegan, Mahsa Saheb, Vahid Hajali
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Total sleep deprivation Green tea extract EGCG Spatial memory Oxidative stress Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/cbe96b9ec0584e159d3c2a8feb2f91b0
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spelling	oai:doaj.org-article:cbe96b9ec0584e159d3c2a8feb2f91b02021-12-02T05:02:42ZThe beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense2405-844010.1016/j.heliyon.2021.e08336https://doaj.org/article/cbe96b9ec0584e159d3c2a8feb2f91b02021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024397https://doaj.org/toc/2405-8440Background: The weight of evidence suggests that sleep is essential for the processes of memory consolidation and sleep deprivation (SD) impairs the retention of long-term memory in both humans and experimental animals, which is associated with oxidative stress damage within the brain. Green tea polyphenols have revealed carcinogenic, antioxidant, anti-, and anti-mutagenic properties. We aimed to investigate the possible protective effect of green tea extract (GTE) and its main active catechin, epigallocatechin-3-gallate (EGCG), on post-training total sleep deprivation (TSD) -induced spatial memory deficits and oxidative stress profile in the hippocampus of the rat. Methods: Male rats were treated with saline, GTE (100 and 200 mg/kg/day), and EGCG (50 mg/kg/day) intraperitoneally for 21 days and then trained in Morris water maze (MWM) in a single day protocol. Immediately after the end of MWM training, animals were sleep deprived for 6 h by the gentle handling method, and then evaluated for spatial memory. Hippocampal levels of malondialdehyde, (MDA), and thiol was assessed as oxidant and antioxidant markers. Results: Spatial memory was impaired in the TSD group and GTE at the dose of 200 mg/kg/day as well as EGCG at the dose of 50 mg/kg/day could reverse the impairment to the saline-treated levels. Despite the unchanged MDA levels, hippocampal total thiol was significantly decreased after TSD and EGCG increased it to the basal levels. Conclusion: In conclusion, green tea and its main catechin, EGCG, could prevent memory impairments during 6 h of TSD; probably through normalizing the antioxidant thiol defense system which was impaired during TSD.Fatemeh ForouzanfarJamileh GholamiMaryam ForoughniaBahareh PayvarSaeideh NematiMohammad Amin KhodadadeganMahsa SahebVahid HajaliElsevierarticleTotal sleep deprivationGreen tea extractEGCGSpatial memoryOxidative stressScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08336- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Total sleep deprivation Green tea extract EGCG Spatial memory Oxidative stress Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Total sleep deprivation Green tea extract EGCG Spatial memory Oxidative stress Science (General) Q1-390 Social sciences (General) H1-99 Fatemeh Forouzanfar Jamileh Gholami Maryam Foroughnia Bahareh Payvar Saeideh Nemati Mohammad Amin Khodadadegan Mahsa Saheb Vahid Hajali The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense
description	Background: The weight of evidence suggests that sleep is essential for the processes of memory consolidation and sleep deprivation (SD) impairs the retention of long-term memory in both humans and experimental animals, which is associated with oxidative stress damage within the brain. Green tea polyphenols have revealed carcinogenic, antioxidant, anti-, and anti-mutagenic properties. We aimed to investigate the possible protective effect of green tea extract (GTE) and its main active catechin, epigallocatechin-3-gallate (EGCG), on post-training total sleep deprivation (TSD) -induced spatial memory deficits and oxidative stress profile in the hippocampus of the rat. Methods: Male rats were treated with saline, GTE (100 and 200 mg/kg/day), and EGCG (50 mg/kg/day) intraperitoneally for 21 days and then trained in Morris water maze (MWM) in a single day protocol. Immediately after the end of MWM training, animals were sleep deprived for 6 h by the gentle handling method, and then evaluated for spatial memory. Hippocampal levels of malondialdehyde, (MDA), and thiol was assessed as oxidant and antioxidant markers. Results: Spatial memory was impaired in the TSD group and GTE at the dose of 200 mg/kg/day as well as EGCG at the dose of 50 mg/kg/day could reverse the impairment to the saline-treated levels. Despite the unchanged MDA levels, hippocampal total thiol was significantly decreased after TSD and EGCG increased it to the basal levels. Conclusion: In conclusion, green tea and its main catechin, EGCG, could prevent memory impairments during 6 h of TSD; probably through normalizing the antioxidant thiol defense system which was impaired during TSD.
format	article
author	Fatemeh Forouzanfar Jamileh Gholami Maryam Foroughnia Bahareh Payvar Saeideh Nemati Mohammad Amin Khodadadegan Mahsa Saheb Vahid Hajali
author_facet	Fatemeh Forouzanfar Jamileh Gholami Maryam Foroughnia Bahareh Payvar Saeideh Nemati Mohammad Amin Khodadadegan Mahsa Saheb Vahid Hajali
author_sort	Fatemeh Forouzanfar
title	The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense
title_short	The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense
title_full	The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense
title_fullStr	The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense
title_full_unstemmed	The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense
title_sort	beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cbe96b9ec0584e159d3c2a8feb2f91b0
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The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense

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