Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells

Pancreatic ductal adenocarcinoma has a collagen-rich dense extracellular matrix that promotes malignancy of cancer cells. Here, the authors show that fibrillar collagen that is cancer-cell-derived, but not stroma-derived, selectively restrains tumor growth under control of their pC-proteinase, BMP1.

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Autores principales:	Chenxi Tian, Ying Huang, Karl R. Clauser, Steffen Rickelt, Allison N. Lau, Steven A. Carr, Matthew G. Vander Heiden, Richard O. Hynes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cbed56b38aff4504b548e616901c398d
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spelling	oai:doaj.org-article:cbed56b38aff4504b548e616901c398d2021-12-02T16:45:05ZSuppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells10.1038/s41467-021-22490-92041-1723https://doaj.org/article/cbed56b38aff4504b548e616901c398d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22490-9https://doaj.org/toc/2041-1723Pancreatic ductal adenocarcinoma has a collagen-rich dense extracellular matrix that promotes malignancy of cancer cells. Here, the authors show that fibrillar collagen that is cancer-cell-derived, but not stroma-derived, selectively restrains tumor growth under control of their pC-proteinase, BMP1.Chenxi TianYing HuangKarl R. ClauserSteffen RickeltAllison N. LauSteven A. CarrMatthew G. Vander HeidenRichard O. HynesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chenxi Tian Ying Huang Karl R. Clauser Steffen Rickelt Allison N. Lau Steven A. Carr Matthew G. Vander Heiden Richard O. Hynes Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells
description	Pancreatic ductal adenocarcinoma has a collagen-rich dense extracellular matrix that promotes malignancy of cancer cells. Here, the authors show that fibrillar collagen that is cancer-cell-derived, but not stroma-derived, selectively restrains tumor growth under control of their pC-proteinase, BMP1.
format	article
author	Chenxi Tian Ying Huang Karl R. Clauser Steffen Rickelt Allison N. Lau Steven A. Carr Matthew G. Vander Heiden Richard O. Hynes
author_facet	Chenxi Tian Ying Huang Karl R. Clauser Steffen Rickelt Allison N. Lau Steven A. Carr Matthew G. Vander Heiden Richard O. Hynes
author_sort	Chenxi Tian
title	Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells
title_short	Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells
title_full	Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells
title_fullStr	Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells
title_full_unstemmed	Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells
title_sort	suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cbed56b38aff4504b548e616901c398d
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Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells

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