Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells
Angiogenesis, including the growth of new capillary blood vessels from existing ones and the malignant tumors cells formed vasculogenic mimicry, is quite important for the tumor metastasis. Anti-angiogenesis is one of the significant therapies in tumor treatment, while the clinical angiogenesis inhi...
Guardado en:
Autores principales: | , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/cbedae90512d49a090a92563cde194c9 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:cbedae90512d49a090a92563cde194c9 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:cbedae90512d49a090a92563cde194c92021-11-25T18:13:01ZMarine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells10.3390/md191106411660-3397https://doaj.org/article/cbedae90512d49a090a92563cde194c92021-11-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/641https://doaj.org/toc/1660-3397Angiogenesis, including the growth of new capillary blood vessels from existing ones and the malignant tumors cells formed vasculogenic mimicry, is quite important for the tumor metastasis. Anti-angiogenesis is one of the significant therapies in tumor treatment, while the clinical angiogenesis inhibitors usually exhibit endothelial cells dysfunction and drug resistance. Bis(2,3,6-tribromo-4,5-dihydroxybenzyl)ether (BTDE), a marine algae-derived bromophenol compound, has shown various biological activities, however, its anti-angiogenesis function remains unknown. The present study illustrated that BTDE had anti-angiogenesis effect in vitro through inhibiting human umbilical vein endothelial cells migration, invasion, tube formation, and the activity of matrix metalloproteinases 9 (MMP9), and in vivo BTDE also blocked intersegmental vessel formation in zebrafish embryos. Moreover, BTDE inhibited the migration, invasion, and vasculogenic mimicry formation of lung cancer cell A549. All these results indicated that BTDE could be used as a potential candidate in anti-angiogenesis for the treatment of cancer.Songtao DongZhongyuan ChenLi WangYankai LiuDimitrios StagosXiukun LinMing LiuMDPI AGarticleanti-angiogenesisbromophenolstube formationvasculogenic mimicryBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 641, p 641 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
anti-angiogenesis bromophenols tube formation vasculogenic mimicry Biology (General) QH301-705.5 |
spellingShingle |
anti-angiogenesis bromophenols tube formation vasculogenic mimicry Biology (General) QH301-705.5 Songtao Dong Zhongyuan Chen Li Wang Yankai Liu Dimitrios Stagos Xiukun Lin Ming Liu Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells |
description |
Angiogenesis, including the growth of new capillary blood vessels from existing ones and the malignant tumors cells formed vasculogenic mimicry, is quite important for the tumor metastasis. Anti-angiogenesis is one of the significant therapies in tumor treatment, while the clinical angiogenesis inhibitors usually exhibit endothelial cells dysfunction and drug resistance. Bis(2,3,6-tribromo-4,5-dihydroxybenzyl)ether (BTDE), a marine algae-derived bromophenol compound, has shown various biological activities, however, its anti-angiogenesis function remains unknown. The present study illustrated that BTDE had anti-angiogenesis effect in vitro through inhibiting human umbilical vein endothelial cells migration, invasion, tube formation, and the activity of matrix metalloproteinases 9 (MMP9), and in vivo BTDE also blocked intersegmental vessel formation in zebrafish embryos. Moreover, BTDE inhibited the migration, invasion, and vasculogenic mimicry formation of lung cancer cell A549. All these results indicated that BTDE could be used as a potential candidate in anti-angiogenesis for the treatment of cancer. |
format |
article |
author |
Songtao Dong Zhongyuan Chen Li Wang Yankai Liu Dimitrios Stagos Xiukun Lin Ming Liu |
author_facet |
Songtao Dong Zhongyuan Chen Li Wang Yankai Liu Dimitrios Stagos Xiukun Lin Ming Liu |
author_sort |
Songtao Dong |
title |
Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells |
title_short |
Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells |
title_full |
Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells |
title_fullStr |
Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells |
title_full_unstemmed |
Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells |
title_sort |
marine bromophenol bis(2,3,6-tribromo-4,5-dihydroxybenzyl)ether inhibits angiogenesis in human umbilical vein endothelial cells and reduces vasculogenic mimicry in human lung cancer a549 cells |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/cbedae90512d49a090a92563cde194c9 |
work_keys_str_mv |
AT songtaodong marinebromophenolbis236tribromo45dihydroxybenzyletherinhibitsangiogenesisinhumanumbilicalveinendothelialcellsandreducesvasculogenicmimicryinhumanlungcancera549cells AT zhongyuanchen marinebromophenolbis236tribromo45dihydroxybenzyletherinhibitsangiogenesisinhumanumbilicalveinendothelialcellsandreducesvasculogenicmimicryinhumanlungcancera549cells AT liwang marinebromophenolbis236tribromo45dihydroxybenzyletherinhibitsangiogenesisinhumanumbilicalveinendothelialcellsandreducesvasculogenicmimicryinhumanlungcancera549cells AT yankailiu marinebromophenolbis236tribromo45dihydroxybenzyletherinhibitsangiogenesisinhumanumbilicalveinendothelialcellsandreducesvasculogenicmimicryinhumanlungcancera549cells AT dimitriosstagos marinebromophenolbis236tribromo45dihydroxybenzyletherinhibitsangiogenesisinhumanumbilicalveinendothelialcellsandreducesvasculogenicmimicryinhumanlungcancera549cells AT xiukunlin marinebromophenolbis236tribromo45dihydroxybenzyletherinhibitsangiogenesisinhumanumbilicalveinendothelialcellsandreducesvasculogenicmimicryinhumanlungcancera549cells AT mingliu marinebromophenolbis236tribromo45dihydroxybenzyletherinhibitsangiogenesisinhumanumbilicalveinendothelialcellsandreducesvasculogenicmimicryinhumanlungcancera549cells |
_version_ |
1718411524528144384 |