Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients

Abstract B cell responses to tumor antigens occur early in breast tumors and may identify immunogenic drivers of tumorigenesis. Sixty-two candidate antigens were identified prior to palpable tumor development in TgMMTV-neu and C3(1)Tag transgenic mouse mammary tumor models. Five antigens (VPS35, ARP...

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Autores principales:	Sasha E. Stanton, Ekram Gad, Erik Ramos, Lauren Corulli, James Annis, Jennifer Childs, Hiroyuki Katayama, Samir Hanash, Jeffrey Marks, Mary L. Disis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/cbefc55184bd46c3b7bb9b9c4a6ec2a5
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spelling	oai:doaj.org-article:cbefc55184bd46c3b7bb9b9c4a6ec2a52021-12-02T16:57:12ZTumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients10.1038/s41523-021-00257-12374-4677https://doaj.org/article/cbefc55184bd46c3b7bb9b9c4a6ec2a52021-05-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00257-1https://doaj.org/toc/2374-4677Abstract B cell responses to tumor antigens occur early in breast tumors and may identify immunogenic drivers of tumorigenesis. Sixty-two candidate antigens were identified prior to palpable tumor development in TgMMTV-neu and C3(1)Tag transgenic mouse mammary tumor models. Five antigens (VPS35, ARPC2, SERBP1, KRT8, and PDIA6) were selected because their decreased expression decreased survival in human HER2 positive and triple negative cell lines in a siRNA screen. Vaccination with antigen-specific epitopes, conserved between mouse and human, inhibited tumor growth in both transgenic mouse models. Increased IgG autoantibodies to the antigens were elevated in serum from women with ductal carcinoma in situ (DCIS) and invasive breast cancer (IBC). The autoantibodies differentiated women with DCIS from control with AUC 0.93 (95% CI 0.88–0.98, p < 0.0001). The tumor antigens identified early in the development of breast cancer in mouse mammary tumor models were conserved in human disease, and potentially identify early diagnostic markers in human breast tumors.Sasha E. StantonEkram GadErik RamosLauren CorulliJames AnnisJennifer ChildsHiroyuki KatayamaSamir HanashJeffrey MarksMary L. DisisNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sasha E. Stanton Ekram Gad Erik Ramos Lauren Corulli James Annis Jennifer Childs Hiroyuki Katayama Samir Hanash Jeffrey Marks Mary L. Disis Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients
description	Abstract B cell responses to tumor antigens occur early in breast tumors and may identify immunogenic drivers of tumorigenesis. Sixty-two candidate antigens were identified prior to palpable tumor development in TgMMTV-neu and C3(1)Tag transgenic mouse mammary tumor models. Five antigens (VPS35, ARPC2, SERBP1, KRT8, and PDIA6) were selected because their decreased expression decreased survival in human HER2 positive and triple negative cell lines in a siRNA screen. Vaccination with antigen-specific epitopes, conserved between mouse and human, inhibited tumor growth in both transgenic mouse models. Increased IgG autoantibodies to the antigens were elevated in serum from women with ductal carcinoma in situ (DCIS) and invasive breast cancer (IBC). The autoantibodies differentiated women with DCIS from control with AUC 0.93 (95% CI 0.88–0.98, p < 0.0001). The tumor antigens identified early in the development of breast cancer in mouse mammary tumor models were conserved in human disease, and potentially identify early diagnostic markers in human breast tumors.
format	article
author	Sasha E. Stanton Ekram Gad Erik Ramos Lauren Corulli James Annis Jennifer Childs Hiroyuki Katayama Samir Hanash Jeffrey Marks Mary L. Disis
author_facet	Sasha E. Stanton Ekram Gad Erik Ramos Lauren Corulli James Annis Jennifer Childs Hiroyuki Katayama Samir Hanash Jeffrey Marks Mary L. Disis
author_sort	Sasha E. Stanton
title	Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients
title_short	Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients
title_full	Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients
title_fullStr	Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients
title_full_unstemmed	Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients
title_sort	tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cbefc55184bd46c3b7bb9b9c4a6ec2a5
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Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients

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