Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study.

<h4>Background/objective</h4>Weight loss is a predictor of shorter survival in amyotrophic lateral sclerosis (ALS). We performed serial measures of body composition using Dual-energy X-ray Absorptiometry (DEXA) in ALS patients to explore its utility as a biomarker of disease progression....

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Autores principales:	Ikjae Lee, Mohamed Kazamel, Tarrant McPherson, Jeremy McAdam, Marcas Bamman, Amy Amara, Daniel L Smith, Peter H King
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cbf11b03b4c740548528a386c9a157d3
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spelling	oai:doaj.org-article:cbf11b03b4c740548528a386c9a157d32021-12-02T20:05:42ZFat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study.1932-620310.1371/journal.pone.0251087https://doaj.org/article/cbf11b03b4c740548528a386c9a157d32021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251087https://doaj.org/toc/1932-6203<h4>Background/objective</h4>Weight loss is a predictor of shorter survival in amyotrophic lateral sclerosis (ALS). We performed serial measures of body composition using Dual-energy X-ray Absorptiometry (DEXA) in ALS patients to explore its utility as a biomarker of disease progression.<h4>Methods</h4>DEXA data were obtained from participants with ALS (enrollment, at 6- and 12- months follow ups) and Parkinson's disease (enrollment and at 4-month follow up) as a comparator group. Body mass index, total lean mass index, appendicular lean mass index, total fat mass index, and percentage body fat at enrollment were compared between the ALS and PD cohorts and age-matched normative data obtained from the National Health and Nutrition Examination Survey database. Estimated monthly changes of body composition measures in the ALS cohort were compared to those of the PD cohort and were correlated with disease progression measured by the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R).<h4>Results</h4>The ALS cohort (N = 20) had lower baseline total and appendicular lean mass indices compared to the PD cohort (N = 20) and general population. Loss in total and appendicular lean masses were found to be significantly associated with follow-up time. Low baseline percentage body fat (r = 0.72, p = 0.04), loss of percentage body fat (r = 0.81, p = 0.01), and total fat mass index (r = 0.73, p = 0.04) during follow up correlated significantly with monthly decline of ALSFRS-R scores in ALS cohort who had 2 or more follow-ups (N = 8).<h4>Conclusion</h4>Measurement of body composition with DEXA might serve as a biomarker for rapid disease progression in ALS.Ikjae LeeMohamed KazamelTarrant McPhersonJeremy McAdamMarcas BammanAmy AmaraDaniel L SmithPeter H KingPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251087 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ikjae Lee Mohamed Kazamel Tarrant McPherson Jeremy McAdam Marcas Bamman Amy Amara Daniel L Smith Peter H King Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study.
description	<h4>Background/objective</h4>Weight loss is a predictor of shorter survival in amyotrophic lateral sclerosis (ALS). We performed serial measures of body composition using Dual-energy X-ray Absorptiometry (DEXA) in ALS patients to explore its utility as a biomarker of disease progression.<h4>Methods</h4>DEXA data were obtained from participants with ALS (enrollment, at 6- and 12- months follow ups) and Parkinson's disease (enrollment and at 4-month follow up) as a comparator group. Body mass index, total lean mass index, appendicular lean mass index, total fat mass index, and percentage body fat at enrollment were compared between the ALS and PD cohorts and age-matched normative data obtained from the National Health and Nutrition Examination Survey database. Estimated monthly changes of body composition measures in the ALS cohort were compared to those of the PD cohort and were correlated with disease progression measured by the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R).<h4>Results</h4>The ALS cohort (N = 20) had lower baseline total and appendicular lean mass indices compared to the PD cohort (N = 20) and general population. Loss in total and appendicular lean masses were found to be significantly associated with follow-up time. Low baseline percentage body fat (r = 0.72, p = 0.04), loss of percentage body fat (r = 0.81, p = 0.01), and total fat mass index (r = 0.73, p = 0.04) during follow up correlated significantly with monthly decline of ALSFRS-R scores in ALS cohort who had 2 or more follow-ups (N = 8).<h4>Conclusion</h4>Measurement of body composition with DEXA might serve as a biomarker for rapid disease progression in ALS.
format	article
author	Ikjae Lee Mohamed Kazamel Tarrant McPherson Jeremy McAdam Marcas Bamman Amy Amara Daniel L Smith Peter H King
author_facet	Ikjae Lee Mohamed Kazamel Tarrant McPherson Jeremy McAdam Marcas Bamman Amy Amara Daniel L Smith Peter H King
author_sort	Ikjae Lee
title	Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study.
title_short	Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study.
title_full	Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study.
title_fullStr	Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study.
title_full_unstemmed	Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study.
title_sort	fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: exploring the utility of dual-energy x-ray absorptiometry in a prospective study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/cbf11b03b4c740548528a386c9a157d3
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Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study.

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