T-Cell Acute Lymphoblastic Leukemia—Current Concepts in Molecular Biology and Management

T-cell acute lymphoblastic leukemia (T-ALL) is an uncommon, yet aggressive leukemia that accounts for approximately one-fourth of acute lymphoblastic leukemia (ALL) cases. CDKN2A/CDKN2B and NOTCH1 are the most common mutated genes in T-ALL. Ch...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Parveen Shiraz, Waqas Jehangir, Vaibhav Agrawal
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acute lymphoblastic leukemia T-cell leukemia NOTCH Nelarabine Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cbf3dcaa43fb42edb04875642153b60d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cbf3dcaa43fb42edb04875642153b60d
record_format	dspace
spelling	oai:doaj.org-article:cbf3dcaa43fb42edb04875642153b60d2021-11-25T16:49:40ZT-Cell Acute Lymphoblastic Leukemia—Current Concepts in Molecular Biology and Management10.3390/biomedicines91116212227-9059https://doaj.org/article/cbf3dcaa43fb42edb04875642153b60d2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1621https://doaj.org/toc/2227-9059T-cell acute lymphoblastic leukemia (T-ALL) is an uncommon, yet aggressive leukemia that accounts for approximately one-fourth of acute lymphoblastic leukemia (ALL) cases. <i>CDKN2A</i>/<i>CDKN2B</i> and <i>NOTCH1</i> are the most common mutated genes in T-ALL. Children and young adults are treated with pediatric intensive regimens and have superior outcomes compared to older adults. In children and young adults, Nelarabine added to frontline chemotherapy improves outcomes and end of consolidation measurable residual disease has emerged as the most valuable prognostic marker. While outcomes for de-novo disease are steadily improving, patients with relapsed and refractory T-ALL fare poorly. Newer targeted therapies are being studied in large clinical trials and have the potential to further improve outcomes. The role of allogeneic stem cell transplant (HSCT) is evolving due to the increased use of pediatric-inspired regimens and MRD monitoring. In this review we will discuss the biology, treatment, and outcomes in pediatric and adult T-ALL.Parveen ShirazWaqas JehangirVaibhav AgrawalMDPI AGarticleacute lymphoblastic leukemiaT-cell leukemiaNOTCHNelarabineBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1621, p 1621 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute lymphoblastic leukemia T-cell leukemia NOTCH Nelarabine Biology (General) QH301-705.5
spellingShingle	acute lymphoblastic leukemia T-cell leukemia NOTCH Nelarabine Biology (General) QH301-705.5 Parveen Shiraz Waqas Jehangir Vaibhav Agrawal T-Cell Acute Lymphoblastic Leukemia—Current Concepts in Molecular Biology and Management
description	T-cell acute lymphoblastic leukemia (T-ALL) is an uncommon, yet aggressive leukemia that accounts for approximately one-fourth of acute lymphoblastic leukemia (ALL) cases. <i>CDKN2A</i>/<i>CDKN2B</i> and <i>NOTCH1</i> are the most common mutated genes in T-ALL. Children and young adults are treated with pediatric intensive regimens and have superior outcomes compared to older adults. In children and young adults, Nelarabine added to frontline chemotherapy improves outcomes and end of consolidation measurable residual disease has emerged as the most valuable prognostic marker. While outcomes for de-novo disease are steadily improving, patients with relapsed and refractory T-ALL fare poorly. Newer targeted therapies are being studied in large clinical trials and have the potential to further improve outcomes. The role of allogeneic stem cell transplant (HSCT) is evolving due to the increased use of pediatric-inspired regimens and MRD monitoring. In this review we will discuss the biology, treatment, and outcomes in pediatric and adult T-ALL.
format	article
author	Parveen Shiraz Waqas Jehangir Vaibhav Agrawal
author_facet	Parveen Shiraz Waqas Jehangir Vaibhav Agrawal
author_sort	Parveen Shiraz
title	T-Cell Acute Lymphoblastic Leukemia—Current Concepts in Molecular Biology and Management
title_short	T-Cell Acute Lymphoblastic Leukemia—Current Concepts in Molecular Biology and Management
title_full	T-Cell Acute Lymphoblastic Leukemia—Current Concepts in Molecular Biology and Management
title_fullStr	T-Cell Acute Lymphoblastic Leukemia—Current Concepts in Molecular Biology and Management
title_full_unstemmed	T-Cell Acute Lymphoblastic Leukemia—Current Concepts in Molecular Biology and Management
title_sort	t-cell acute lymphoblastic leukemia—current concepts in molecular biology and management
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cbf3dcaa43fb42edb04875642153b60d
work_keys_str_mv	AT parveenshiraz tcellacutelymphoblasticleukemiacurrentconceptsinmolecularbiologyandmanagement AT waqasjehangir tcellacutelymphoblasticleukemiacurrentconceptsinmolecularbiologyandmanagement AT vaibhavagrawal tcellacutelymphoblasticleukemiacurrentconceptsinmolecularbiologyandmanagement
_version_	1718412923765784576

T-Cell Acute Lymphoblastic Leukemia—Current Concepts in Molecular Biology and Management

Ejemplares similares