Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

Programmed death-ligand 1 (PD-L1) is involved in the inhibition of antigen specific T cells via ligation of programmed death 1 (PD-1). Here, the authors show checkpoint inhibition by use of small molecule inhibition of PD-L1 which in a humanised mouse model was shown to restore T cell responses and...

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Autores principales:	Jang-June Park, Emily P. Thi, Victor H. Carpio, Yingzhi Bi, Andrew G. Cole, Bruce D. Dorsey, Kristi Fan, Troy Harasym, Christina L. Iott, Salam Kadhim, Jin Hyang Kim, Amy C. H. Lee, Duyan Nguyen, Bhavna S. Paratala, Ruiqing Qiu, Andre White, Damodharan Lakshminarasimhan, Christopher Leo, Robert K. Suto, Rene Rijnbrand, Sunny Tang, Michael J. Sofia, Chris B. Moore
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cbf4ada82c004c6dad7c4c374ea066bb
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spelling	oai:doaj.org-article:cbf4ada82c004c6dad7c4c374ea066bb2021-12-02T10:59:13ZCheckpoint inhibition through small molecule-induced internalization of programmed death-ligand 110.1038/s41467-021-21410-12041-1723https://doaj.org/article/cbf4ada82c004c6dad7c4c374ea066bb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21410-1https://doaj.org/toc/2041-1723Programmed death-ligand 1 (PD-L1) is involved in the inhibition of antigen specific T cells via ligation of programmed death 1 (PD-1). Here, the authors show checkpoint inhibition by use of small molecule inhibition of PD-L1 which in a humanised mouse model was shown to restore T cell responses and reduced tumour burden.Jang-June ParkEmily P. ThiVictor H. CarpioYingzhi BiAndrew G. ColeBruce D. DorseyKristi FanTroy HarasymChristina L. IottSalam KadhimJin Hyang KimAmy C. H. LeeDuyan NguyenBhavna S. ParatalaRuiqing QiuAndre WhiteDamodharan LakshminarasimhanChristopher LeoRobert K. SutoRene RijnbrandSunny TangMichael J. SofiaChris B. MooreNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jang-June Park Emily P. Thi Victor H. Carpio Yingzhi Bi Andrew G. Cole Bruce D. Dorsey Kristi Fan Troy Harasym Christina L. Iott Salam Kadhim Jin Hyang Kim Amy C. H. Lee Duyan Nguyen Bhavna S. Paratala Ruiqing Qiu Andre White Damodharan Lakshminarasimhan Christopher Leo Robert K. Suto Rene Rijnbrand Sunny Tang Michael J. Sofia Chris B. Moore Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
description	Programmed death-ligand 1 (PD-L1) is involved in the inhibition of antigen specific T cells via ligation of programmed death 1 (PD-1). Here, the authors show checkpoint inhibition by use of small molecule inhibition of PD-L1 which in a humanised mouse model was shown to restore T cell responses and reduced tumour burden.
format	article
author	Jang-June Park Emily P. Thi Victor H. Carpio Yingzhi Bi Andrew G. Cole Bruce D. Dorsey Kristi Fan Troy Harasym Christina L. Iott Salam Kadhim Jin Hyang Kim Amy C. H. Lee Duyan Nguyen Bhavna S. Paratala Ruiqing Qiu Andre White Damodharan Lakshminarasimhan Christopher Leo Robert K. Suto Rene Rijnbrand Sunny Tang Michael J. Sofia Chris B. Moore
author_facet	Jang-June Park Emily P. Thi Victor H. Carpio Yingzhi Bi Andrew G. Cole Bruce D. Dorsey Kristi Fan Troy Harasym Christina L. Iott Salam Kadhim Jin Hyang Kim Amy C. H. Lee Duyan Nguyen Bhavna S. Paratala Ruiqing Qiu Andre White Damodharan Lakshminarasimhan Christopher Leo Robert K. Suto Rene Rijnbrand Sunny Tang Michael J. Sofia Chris B. Moore
author_sort	Jang-June Park
title	Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
title_short	Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
title_full	Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
title_fullStr	Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
title_full_unstemmed	Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
title_sort	checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cbf4ada82c004c6dad7c4c374ea066bb
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Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

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