Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.

<h4>Objective</h4>Diabetes is associated with increased risk of cancer at several sites, but its association with risk of bladder cancer is still controversial. We examined this association by conducting a systematic review and meta-analysis of cohort studies.<h4>Methods</h4>...

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Autores principales:	Xin Xu, Jian Wu, Yeqing Mao, Yi Zhu, Zhenghui Hu, Xianglai Xu, Yiwei Lin, Hong Chen, Xiangyi Zheng, Jie Qin, Liping Xie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cbf61848e5a04deca160823aaf12f99e
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spelling	oai:doaj.org-article:cbf61848e5a04deca160823aaf12f99e2021-11-18T07:54:53ZDiabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.1932-620310.1371/journal.pone.0058079https://doaj.org/article/cbf61848e5a04deca160823aaf12f99e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23472134/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Diabetes is associated with increased risk of cancer at several sites, but its association with risk of bladder cancer is still controversial. We examined this association by conducting a systematic review and meta-analysis of cohort studies.<h4>Methods</h4>Studies were identified by searching PubMed, EMBASE, Scopus, Web of Science, Cochrane register, and Chinese National Knowledge Infrastructure (CNKI) databases through April 29, 2012. Summary relative risks (SRRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model.<h4>Results</h4>A total of fifteen cohort studies were included in this meta-analysis. Analysis of all studies showed that diabetes was associated with a borderline statistically significant increased risk of bladder cancer (RR 1.11, 95% CI 1.00-1.23; p<0.001 for heterogeneity; I(2) = 84%). When restricting the analysis to studies that had adjusted for cigarette smoking (n = 6) or more than three confounders (n = 7), the RRs were 1.32 (95% CI 1.18-1.49) and 1.20 (95% CI 1.02-1.42), respectively. There was no significant publication bias (p = 0.62 for Egger's regression asymmetry test).<h4>Conclusions</h4>Our findings support that diabetes was associated with an increased risk of bladder cancer. More future studies are warranted to get a better understanding of the association and to provide convincing evidence for clinical practice in bladder cancer prevention.Xin XuJian WuYeqing MaoYi ZhuZhenghui HuXianglai XuYiwei LinHong ChenXiangyi ZhengJie QinLiping XiePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58079 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Xu Jian Wu Yeqing Mao Yi Zhu Zhenghui Hu Xianglai Xu Yiwei Lin Hong Chen Xiangyi Zheng Jie Qin Liping Xie Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.
description	<h4>Objective</h4>Diabetes is associated with increased risk of cancer at several sites, but its association with risk of bladder cancer is still controversial. We examined this association by conducting a systematic review and meta-analysis of cohort studies.<h4>Methods</h4>Studies were identified by searching PubMed, EMBASE, Scopus, Web of Science, Cochrane register, and Chinese National Knowledge Infrastructure (CNKI) databases through April 29, 2012. Summary relative risks (SRRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model.<h4>Results</h4>A total of fifteen cohort studies were included in this meta-analysis. Analysis of all studies showed that diabetes was associated with a borderline statistically significant increased risk of bladder cancer (RR 1.11, 95% CI 1.00-1.23; p<0.001 for heterogeneity; I(2) = 84%). When restricting the analysis to studies that had adjusted for cigarette smoking (n = 6) or more than three confounders (n = 7), the RRs were 1.32 (95% CI 1.18-1.49) and 1.20 (95% CI 1.02-1.42), respectively. There was no significant publication bias (p = 0.62 for Egger's regression asymmetry test).<h4>Conclusions</h4>Our findings support that diabetes was associated with an increased risk of bladder cancer. More future studies are warranted to get a better understanding of the association and to provide convincing evidence for clinical practice in bladder cancer prevention.
format	article
author	Xin Xu Jian Wu Yeqing Mao Yi Zhu Zhenghui Hu Xianglai Xu Yiwei Lin Hong Chen Xiangyi Zheng Jie Qin Liping Xie
author_facet	Xin Xu Jian Wu Yeqing Mao Yi Zhu Zhenghui Hu Xianglai Xu Yiwei Lin Hong Chen Xiangyi Zheng Jie Qin Liping Xie
author_sort	Xin Xu
title	Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.
title_short	Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.
title_full	Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.
title_fullStr	Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.
title_full_unstemmed	Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.
title_sort	diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/cbf61848e5a04deca160823aaf12f99e
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Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.

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