The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F

Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) is known for its anti-inflammatory properties during the immune response, and influences negatively on TNF-α expression levels. Genetic epidemiology studies have identified polymorphisms located in the TREM2 gene associated with neuro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vesna Gorenjak, Alex-Ander Aldasoro Arguinano, Sébastien Dadé, Maria G. Stathopoulou, Dwaine R. Vance, Christine Masson, Sophie Visvikis-Siest
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cbf725a4937f40fd8d563f7e3414b048
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cbf725a4937f40fd8d563f7e3414b048
record_format	dspace
spelling	oai:doaj.org-article:cbf725a4937f40fd8d563f7e3414b0482021-12-02T15:08:36ZThe polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F10.1038/s41598-018-25553-y2045-2322https://doaj.org/article/cbf725a4937f40fd8d563f7e3414b0482018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25553-yhttps://doaj.org/toc/2045-2322Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) is known for its anti-inflammatory properties during the immune response, and influences negatively on TNF-α expression levels. Genetic epidemiology studies have identified polymorphisms located in the TREM2 gene associated with neurodegenerative and chronic inflammatory diseases. TREM2 levels have been observed to affect plasma levels of TNF-α and plaque stability in symptomatic and asymptomatic patients with carotid stenosis. In this study, we investigated polymorphisms located in the TREM2 gene region and association with TNF-α levels and the intima media thickness of the femoral artery. The discovery population from the STANISLAS Family Study comprised of 809 individuals, whereas the replication population utilized an independent cohort of French origin (n = 916). Our results suggest that the minor allele (T) of SNP rs6918289 is positively associated with elevated plasma levels of TNF-α in discovery and replication populations (P = 0.0026, SE = 0.04 and P = 0.023, SE = 0.09, respectively), including femoral artery thickness in the discovery cohort (P = 0.026, SE = 0.009). Results indicate that rs6918289 may be considered as a risk factor for inflammatory diseases and could be used in stratified medicine with patients diagnosed with chronic inflammatory-related conditions, such as atherosclerosis.Vesna GorenjakAlex-Ander Aldasoro ArguinanoSébastien DadéMaria G. StathopoulouDwaine R. VanceChristine MassonSophie Visvikis-SiestNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vesna Gorenjak Alex-Ander Aldasoro Arguinano Sébastien Dadé Maria G. Stathopoulou Dwaine R. Vance Christine Masson Sophie Visvikis-Siest The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F
description	Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) is known for its anti-inflammatory properties during the immune response, and influences negatively on TNF-α expression levels. Genetic epidemiology studies have identified polymorphisms located in the TREM2 gene associated with neurodegenerative and chronic inflammatory diseases. TREM2 levels have been observed to affect plasma levels of TNF-α and plaque stability in symptomatic and asymptomatic patients with carotid stenosis. In this study, we investigated polymorphisms located in the TREM2 gene region and association with TNF-α levels and the intima media thickness of the femoral artery. The discovery population from the STANISLAS Family Study comprised of 809 individuals, whereas the replication population utilized an independent cohort of French origin (n = 916). Our results suggest that the minor allele (T) of SNP rs6918289 is positively associated with elevated plasma levels of TNF-α in discovery and replication populations (P = 0.0026, SE = 0.04 and P = 0.023, SE = 0.09, respectively), including femoral artery thickness in the discovery cohort (P = 0.026, SE = 0.009). Results indicate that rs6918289 may be considered as a risk factor for inflammatory diseases and could be used in stratified medicine with patients diagnosed with chronic inflammatory-related conditions, such as atherosclerosis.
format	article
author	Vesna Gorenjak Alex-Ander Aldasoro Arguinano Sébastien Dadé Maria G. Stathopoulou Dwaine R. Vance Christine Masson Sophie Visvikis-Siest
author_facet	Vesna Gorenjak Alex-Ander Aldasoro Arguinano Sébastien Dadé Maria G. Stathopoulou Dwaine R. Vance Christine Masson Sophie Visvikis-Siest
author_sort	Vesna Gorenjak
title	The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F
title_short	The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F
title_full	The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F
title_fullStr	The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F
title_full_unstemmed	The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F
title_sort	polymorphism rs6918289 located in the downstream region of the trem2 gene is associated with tnf-α levels and imt-f
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cbf725a4937f40fd8d563f7e3414b048
work_keys_str_mv	AT vesnagorenjak thepolymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT alexanderaldasoroarguinano thepolymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT sebastiendade thepolymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT mariagstathopoulou thepolymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT dwainervance thepolymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT christinemasson thepolymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT sophievisvikissiest thepolymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT vesnagorenjak polymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT alexanderaldasoroarguinano polymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT sebastiendade polymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT mariagstathopoulou polymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT dwainervance polymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT christinemasson polymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf AT sophievisvikissiest polymorphismrs6918289locatedinthedownstreamregionofthetrem2geneisassociatedwithtnfalevelsandimtf
_version_	1718388088319770624

The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F

Ejemplares similares