An update on subtypes of hepatocellular carcinoma: From morphology to molecular

The morphologic spectrum of hepatocellular carcinoma (HCC) is quite broad. While in about one-third of cases, the neoplasms can be categorized into meaningful subtypes based on morphology, a vast majority of these neoplasms are morphologically heterogeneous. With extensive tumor profiling, data has...

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Autores principales:	Monika Vyas, Dhanpat Jain
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	carcinoma hepatocellular molecular subtypes Pathology RB1-214 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/cbf7b0446e2d41628b2f876857d3a6f3
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spelling	oai:doaj.org-article:cbf7b0446e2d41628b2f876857d3a6f32021-12-02T17:49:11ZAn update on subtypes of hepatocellular carcinoma: From morphology to molecular0377-492910.4103/IJPM.IJPM_751_20https://doaj.org/article/cbf7b0446e2d41628b2f876857d3a6f32021-01-01T00:00:00Zhttp://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=5;spage=112;epage=120;aulast=Vyashttps://doaj.org/toc/0377-4929The morphologic spectrum of hepatocellular carcinoma (HCC) is quite broad. While in about one-third of cases, the neoplasms can be categorized into meaningful subtypes based on morphology, a vast majority of these neoplasms are morphologically heterogeneous. With extensive tumor profiling, data has begun to emerge which can correlate specific morphologic features with underlying molecular signatures. A true morphologic subtype not only has reproducible H & E features, further supported by specific immunohistochemical or molecular signatures, but also has specific clinical implications and prognostic associations. Eight such morphologic subtypes are recognized by the 2019 WHO classification of tumors with a few more additional subtypes described in the literature. The goal of this review is to familiarize the reader with the morphologic subtypes and elaborate on the clinical and molecular associations of these neoplasms.Monika VyasDhanpat JainWolters Kluwer Medknow PublicationsarticlecarcinomahepatocellularmolecularsubtypesPathologyRB1-214MicrobiologyQR1-502ENIndian Journal of Pathology and Microbiology, Vol 64, Iss 5, Pp 112-120 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carcinoma hepatocellular molecular subtypes Pathology RB1-214 Microbiology QR1-502
spellingShingle	carcinoma hepatocellular molecular subtypes Pathology RB1-214 Microbiology QR1-502 Monika Vyas Dhanpat Jain An update on subtypes of hepatocellular carcinoma: From morphology to molecular
description	The morphologic spectrum of hepatocellular carcinoma (HCC) is quite broad. While in about one-third of cases, the neoplasms can be categorized into meaningful subtypes based on morphology, a vast majority of these neoplasms are morphologically heterogeneous. With extensive tumor profiling, data has begun to emerge which can correlate specific morphologic features with underlying molecular signatures. A true morphologic subtype not only has reproducible H & E features, further supported by specific immunohistochemical or molecular signatures, but also has specific clinical implications and prognostic associations. Eight such morphologic subtypes are recognized by the 2019 WHO classification of tumors with a few more additional subtypes described in the literature. The goal of this review is to familiarize the reader with the morphologic subtypes and elaborate on the clinical and molecular associations of these neoplasms.
format	article
author	Monika Vyas Dhanpat Jain
author_facet	Monika Vyas Dhanpat Jain
author_sort	Monika Vyas
title	An update on subtypes of hepatocellular carcinoma: From morphology to molecular
title_short	An update on subtypes of hepatocellular carcinoma: From morphology to molecular
title_full	An update on subtypes of hepatocellular carcinoma: From morphology to molecular
title_fullStr	An update on subtypes of hepatocellular carcinoma: From morphology to molecular
title_full_unstemmed	An update on subtypes of hepatocellular carcinoma: From morphology to molecular
title_sort	update on subtypes of hepatocellular carcinoma: from morphology to molecular
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/cbf7b0446e2d41628b2f876857d3a6f3
work_keys_str_mv	AT monikavyas anupdateonsubtypesofhepatocellularcarcinomafrommorphologytomolecular AT dhanpatjain anupdateonsubtypesofhepatocellularcarcinomafrommorphologytomolecular AT monikavyas updateonsubtypesofhepatocellularcarcinomafrommorphologytomolecular AT dhanpatjain updateonsubtypesofhepatocellularcarcinomafrommorphologytomolecular
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An update on subtypes of hepatocellular carcinoma: From morphology to molecular

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