An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A modified RNA transcripts and increase their stab...

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Autores principales: Song Zhu, Ji-Zhong Wang, De Chen, Yu-Tian He, Nan Meng, Min Chen, Rui-Xun Lu, Xin-Hui Chen, Xiao-Lan Zhang, Guang-Rong Yan
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cbf7c7701ca6452e9eff7957bef4b3e5
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spelling oai:doaj.org-article:cbf7c7701ca6452e9eff7957bef4b3e52021-12-02T15:39:28ZAn oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis10.1038/s41467-020-15403-92041-1723https://doaj.org/article/cbf7c7701ca6452e9eff7957bef4b3e52020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15403-9https://doaj.org/toc/2041-1723The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A modified RNA transcripts and increase their stability.Song ZhuJi-Zhong WangDe ChenYu-Tian HeNan MengMin ChenRui-Xun LuXin-Hui ChenXiao-Lan ZhangGuang-Rong YanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Song Zhu
Ji-Zhong Wang
De Chen
Yu-Tian He
Nan Meng
Min Chen
Rui-Xun Lu
Xin-Hui Chen
Xiao-Lan Zhang
Guang-Rong Yan
An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis
description The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A modified RNA transcripts and increase their stability.
format article
author Song Zhu
Ji-Zhong Wang
De Chen
Yu-Tian He
Nan Meng
Min Chen
Rui-Xun Lu
Xin-Hui Chen
Xiao-Lan Zhang
Guang-Rong Yan
author_facet Song Zhu
Ji-Zhong Wang
De Chen
Yu-Tian He
Nan Meng
Min Chen
Rui-Xun Lu
Xin-Hui Chen
Xiao-Lan Zhang
Guang-Rong Yan
author_sort Song Zhu
title An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis
title_short An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis
title_full An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis
title_fullStr An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis
title_full_unstemmed An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis
title_sort oncopeptide regulates m6a recognition by the m6a reader igf2bp1 and tumorigenesis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/cbf7c7701ca6452e9eff7957bef4b3e5
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