Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering

Cardiovascular disease (CVD) currently represents one of the leading causes of death worldwide. It is estimated that more than 17.9 million people die each year due to CVD manifestations. Often, occlusion or stenosis of the vascular network occurs, either in large- or small-diameter blood vessels. M...

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Autores principales:	Panagiotis Mallis, Efstathios Michalopoulos, Catherine Stavropoulos-Giokas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiovascular disease tissue engineering small-diameter vascular grafts mesenchymal stromal cells 3D printing decellularization Technology T Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cbfde7062c344446b33a364730d0f58f
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spelling	oai:doaj.org-article:cbfde7062c344446b33a364730d0f58f2021-11-25T16:46:34ZModern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering10.3390/bioengineering81101742306-5354https://doaj.org/article/cbfde7062c344446b33a364730d0f58f2021-11-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/174https://doaj.org/toc/2306-5354Cardiovascular disease (CVD) currently represents one of the leading causes of death worldwide. It is estimated that more than 17.9 million people die each year due to CVD manifestations. Often, occlusion or stenosis of the vascular network occurs, either in large- or small-diameter blood vessels. Moreover, the obstruction of small vessels such as the coronary arteries may be related to more pronounced events, which can be life-threatening. The gold standard procedure utilizes the transplantation of secondary vessels or the use of synthetic vascular grafts. However, significant adverse reactions have accompanied the use of the above grafts. Therefore, modern therapeutic strategies must be evaluated for better disease administration. In the context of alternative therapies, advanced tissue-engineering approaches including the decellularization procedure and the 3D additive bioprinting methods, have been proposed. In this way the availability of bioengineered vascular grafts will be increased, covering the great demand that exists globally. In this Special Issue of <i>Bioengineering</i>, we tried to highlight the modern approaches which are focused on CVD therapeutics. This issue includes articles related to the efficient development of vascular grafts, 3D printing approaches and suitable atherosclerosis models.Panagiotis MallisEfstathios MichalopoulosCatherine Stavropoulos-GiokasMDPI AGarticlecardiovascular diseasetissue engineeringsmall-diameter vascular graftsmesenchymal stromal cells3D printingdecellularizationTechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 174, p 174 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease tissue engineering small-diameter vascular grafts mesenchymal stromal cells 3D printing decellularization Technology T Biology (General) QH301-705.5
spellingShingle	cardiovascular disease tissue engineering small-diameter vascular grafts mesenchymal stromal cells 3D printing decellularization Technology T Biology (General) QH301-705.5 Panagiotis Mallis Efstathios Michalopoulos Catherine Stavropoulos-Giokas Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering
description	Cardiovascular disease (CVD) currently represents one of the leading causes of death worldwide. It is estimated that more than 17.9 million people die each year due to CVD manifestations. Often, occlusion or stenosis of the vascular network occurs, either in large- or small-diameter blood vessels. Moreover, the obstruction of small vessels such as the coronary arteries may be related to more pronounced events, which can be life-threatening. The gold standard procedure utilizes the transplantation of secondary vessels or the use of synthetic vascular grafts. However, significant adverse reactions have accompanied the use of the above grafts. Therefore, modern therapeutic strategies must be evaluated for better disease administration. In the context of alternative therapies, advanced tissue-engineering approaches including the decellularization procedure and the 3D additive bioprinting methods, have been proposed. In this way the availability of bioengineered vascular grafts will be increased, covering the great demand that exists globally. In this Special Issue of <i>Bioengineering</i>, we tried to highlight the modern approaches which are focused on CVD therapeutics. This issue includes articles related to the efficient development of vascular grafts, 3D printing approaches and suitable atherosclerosis models.
format	article
author	Panagiotis Mallis Efstathios Michalopoulos Catherine Stavropoulos-Giokas
author_facet	Panagiotis Mallis Efstathios Michalopoulos Catherine Stavropoulos-Giokas
author_sort	Panagiotis Mallis
title	Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering
title_short	Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering
title_full	Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering
title_fullStr	Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering
title_full_unstemmed	Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering
title_sort	modern approaches in cardiovascular disease therapeutics: from molecular genetics to tissue engineering
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cbfde7062c344446b33a364730d0f58f
work_keys_str_mv	AT panagiotismallis modernapproachesincardiovasculardiseasetherapeuticsfrommoleculargeneticstotissueengineering AT efstathiosmichalopoulos modernapproachesincardiovasculardiseasetherapeuticsfrommoleculargeneticstotissueengineering AT catherinestavropoulosgiokas modernapproachesincardiovasculardiseasetherapeuticsfrommoleculargeneticstotissueengineering
_version_	1718412981833826304

Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering

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