Engineering mammalian living materials towards clinically relevant therapeutics

Engineered living materials represent a new generation of human-made biotherapeutics that are highly attractive for a myriad of medical applications. In essence, such cell-rich platforms provide encodable bioactivities with extended lifetimes and environmental multi-adaptability currently unattainab...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pedro Lavrador, Vítor M. Gaspar, João F. Mano
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biohybrid constructs Biomaterials Biomedicine Cell engineering Living materials Tissue Engineering Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cc04063e9ba64543918160b746a7f88f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cc04063e9ba64543918160b746a7f88f
record_format	dspace
spelling	oai:doaj.org-article:cc04063e9ba64543918160b746a7f88f2021-11-26T04:31:47ZEngineering mammalian living materials towards clinically relevant therapeutics2352-396410.1016/j.ebiom.2021.103717https://doaj.org/article/cc04063e9ba64543918160b746a7f88f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352396421005119https://doaj.org/toc/2352-3964Engineered living materials represent a new generation of human-made biotherapeutics that are highly attractive for a myriad of medical applications. In essence, such cell-rich platforms provide encodable bioactivities with extended lifetimes and environmental multi-adaptability currently unattainable in conventional biomaterial platforms. Emerging cell bioengineering tools are herein discussed from the perspective of materializing living cells as cooperative building blocks that drive the assembly of multiscale living materials. Owing to their living character, pristine cellular units can also be imparted with additional therapeutically-relevant biofunctionalities. On this focus, the most recent advances on the engineering of mammalian living materials and their biomedical applications are herein outlined, alongside with a critical perspective on major roadblocks hindering their realistic clinical translation. All in all, transposing the concept of leveraging living materials as autologous tissue-building entities and/or self-regulated biotherapeutics opens new realms for improving precision and personalized medicine strategies in the foreseeable future.Pedro LavradorVítor M. GasparJoão F. ManoElsevierarticleBiohybrid constructsBiomaterialsBiomedicineCell engineeringLiving materialsTissue EngineeringMedicineRMedicine (General)R5-920ENEBioMedicine, Vol 74, Iss , Pp 103717- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biohybrid constructs Biomaterials Biomedicine Cell engineering Living materials Tissue Engineering Medicine R Medicine (General) R5-920
spellingShingle	Biohybrid constructs Biomaterials Biomedicine Cell engineering Living materials Tissue Engineering Medicine R Medicine (General) R5-920 Pedro Lavrador Vítor M. Gaspar João F. Mano Engineering mammalian living materials towards clinically relevant therapeutics
description	Engineered living materials represent a new generation of human-made biotherapeutics that are highly attractive for a myriad of medical applications. In essence, such cell-rich platforms provide encodable bioactivities with extended lifetimes and environmental multi-adaptability currently unattainable in conventional biomaterial platforms. Emerging cell bioengineering tools are herein discussed from the perspective of materializing living cells as cooperative building blocks that drive the assembly of multiscale living materials. Owing to their living character, pristine cellular units can also be imparted with additional therapeutically-relevant biofunctionalities. On this focus, the most recent advances on the engineering of mammalian living materials and their biomedical applications are herein outlined, alongside with a critical perspective on major roadblocks hindering their realistic clinical translation. All in all, transposing the concept of leveraging living materials as autologous tissue-building entities and/or self-regulated biotherapeutics opens new realms for improving precision and personalized medicine strategies in the foreseeable future.
format	article
author	Pedro Lavrador Vítor M. Gaspar João F. Mano
author_facet	Pedro Lavrador Vítor M. Gaspar João F. Mano
author_sort	Pedro Lavrador
title	Engineering mammalian living materials towards clinically relevant therapeutics
title_short	Engineering mammalian living materials towards clinically relevant therapeutics
title_full	Engineering mammalian living materials towards clinically relevant therapeutics
title_fullStr	Engineering mammalian living materials towards clinically relevant therapeutics
title_full_unstemmed	Engineering mammalian living materials towards clinically relevant therapeutics
title_sort	engineering mammalian living materials towards clinically relevant therapeutics
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cc04063e9ba64543918160b746a7f88f
work_keys_str_mv	AT pedrolavrador engineeringmammalianlivingmaterialstowardsclinicallyrelevanttherapeutics AT vitormgaspar engineeringmammalianlivingmaterialstowardsclinicallyrelevanttherapeutics AT joaofmano engineeringmammalianlivingmaterialstowardsclinicallyrelevanttherapeutics
_version_	1718409868072714240

Engineering mammalian living materials towards clinically relevant therapeutics

Ejemplares similares