Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations

Purpose: Per- and polyfluoroalkyl substances (PFAS) are human-made chemicals used in daily use products. Recent studies have shown that different perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonate (PFOS) isomers may have different biological effects. In vitro studies have also reported t...

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Autores principales:	Chien-Yu Lin, Hui-Ling Lee, Chikang Wang, Fung-Chang Sung, Ta-Chen Su
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Isomers Red blood cells Erythrogram Per- and polyfluoroalkyl substances (PFAS) Perfluorooctanoic acid (PFOA) Perfluorooctane sulfonate (PFOS) Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/cc04e0d3bb6e4ce6b821964abfd01045
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spelling	oai:doaj.org-article:cc04e0d3bb6e4ce6b821964abfd010452021-11-06T04:16:09ZAssociation between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations0147-651310.1016/j.ecoenv.2021.112902https://doaj.org/article/cc04e0d3bb6e4ce6b821964abfd010452021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321010149https://doaj.org/toc/0147-6513Purpose: Per- and polyfluoroalkyl substances (PFAS) are human-made chemicals used in daily use products. Recent studies have shown that different perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonate (PFOS) isomers may have different biological effects. In vitro studies have also reported that PFAS exposure can alter the structure of hemoglobin (Hb). In epidemiology, however, few studies have investigated the relationship between PFAS exposure and erythrocytes. Additionally, the correlation between PFOA/PFOS isomers and full erythrograms has never been explored. Approach and results: In cohorts comprising young and middle-aged Taiwanese populations, we enrolled 1483 participants (aged between 12 and 63 years) to analyze the correlations between the plasma levels of PFOA/PFOS isomers and whole-blood erythrograms. The study comprised 868 men and 615 women with a mean age of 31.2 years. When all PFOA/PFOS isomers were entered into the multiple linear regression model, the linear PFOA (L-PFOA) levels were positively correlated with the Hb, hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) levels while the branched PFOS (B-PFOS) levels were positively associated with the Hb, HCT, and mean corpuscular hemoglobin concentration (MCHC). The mean value of Hb was the highest (14.66 mg/dL (95% CI =14.52–14.80); P for trend <0.001) when both the L-PFOA and B-PFOS levels were above the 50th percentile. Conclusions: The results imply that PFOA/PFOS isomers may increase the weight and volume of Hb/RBC and that L-PFOA/B-PFOS may have an additive effect on the Hb levels. However, it is also possible PFAS detected at a higher concentration may due to its binding to higher levels of Hb. Further studies are needed to investigate the effects of PFOA/PFOS isomers on RBCs in humans.Chien-Yu LinHui-Ling LeeChikang WangFung-Chang SungTa-Chen SuElsevierarticleIsomersRed blood cellsErythrogramPer- and polyfluoroalkyl substances (PFAS)Perfluorooctanoic acid (PFOA)Perfluorooctane sulfonate (PFOS)Environmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 227, Iss , Pp 112902- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Isomers Red blood cells Erythrogram Per- and polyfluoroalkyl substances (PFAS) Perfluorooctanoic acid (PFOA) Perfluorooctane sulfonate (PFOS) Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Isomers Red blood cells Erythrogram Per- and polyfluoroalkyl substances (PFAS) Perfluorooctanoic acid (PFOA) Perfluorooctane sulfonate (PFOS) Environmental pollution TD172-193.5 Environmental sciences GE1-350 Chien-Yu Lin Hui-Ling Lee Chikang Wang Fung-Chang Sung Ta-Chen Su Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations
description	Purpose: Per- and polyfluoroalkyl substances (PFAS) are human-made chemicals used in daily use products. Recent studies have shown that different perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonate (PFOS) isomers may have different biological effects. In vitro studies have also reported that PFAS exposure can alter the structure of hemoglobin (Hb). In epidemiology, however, few studies have investigated the relationship between PFAS exposure and erythrocytes. Additionally, the correlation between PFOA/PFOS isomers and full erythrograms has never been explored. Approach and results: In cohorts comprising young and middle-aged Taiwanese populations, we enrolled 1483 participants (aged between 12 and 63 years) to analyze the correlations between the plasma levels of PFOA/PFOS isomers and whole-blood erythrograms. The study comprised 868 men and 615 women with a mean age of 31.2 years. When all PFOA/PFOS isomers were entered into the multiple linear regression model, the linear PFOA (L-PFOA) levels were positively correlated with the Hb, hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) levels while the branched PFOS (B-PFOS) levels were positively associated with the Hb, HCT, and mean corpuscular hemoglobin concentration (MCHC). The mean value of Hb was the highest (14.66 mg/dL (95% CI =14.52–14.80); P for trend <0.001) when both the L-PFOA and B-PFOS levels were above the 50th percentile. Conclusions: The results imply that PFOA/PFOS isomers may increase the weight and volume of Hb/RBC and that L-PFOA/B-PFOS may have an additive effect on the Hb levels. However, it is also possible PFAS detected at a higher concentration may due to its binding to higher levels of Hb. Further studies are needed to investigate the effects of PFOA/PFOS isomers on RBCs in humans.
format	article
author	Chien-Yu Lin Hui-Ling Lee Chikang Wang Fung-Chang Sung Ta-Chen Su
author_facet	Chien-Yu Lin Hui-Ling Lee Chikang Wang Fung-Chang Sung Ta-Chen Su
author_sort	Chien-Yu Lin
title	Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations
title_short	Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations
title_full	Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations
title_fullStr	Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations
title_full_unstemmed	Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations
title_sort	association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged taiwanese populations
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cc04e0d3bb6e4ce6b821964abfd01045
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Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations

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