Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is...

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Autores principales:	Peir-Haur Hung, Yung-Chien Hsu, Tsung-Hsien Chen, Chun-Liang Lin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetic kidney disease inflammation albuminuria fibrosis glomerulosclerosis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/cc0514a49ee045d9a98e90d36eec68ca
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spelling	oai:doaj.org-article:cc0514a49ee045d9a98e90d36eec68ca2021-11-11T17:16:57ZRecent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis10.3390/ijms2221118571422-00671661-6596https://doaj.org/article/cc0514a49ee045d9a98e90d36eec68ca2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11857https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.Peir-Haur HungYung-Chien HsuTsung-Hsien ChenChun-Liang LinMDPI AGarticlediabetic kidney diseaseinflammationalbuminuriafibrosisglomerulosclerosisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11857, p 11857 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic kidney disease inflammation albuminuria fibrosis glomerulosclerosis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	diabetic kidney disease inflammation albuminuria fibrosis glomerulosclerosis Biology (General) QH301-705.5 Chemistry QD1-999 Peir-Haur Hung Yung-Chien Hsu Tsung-Hsien Chen Chun-Liang Lin Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
description	Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.
format	article
author	Peir-Haur Hung Yung-Chien Hsu Tsung-Hsien Chen Chun-Liang Lin
author_facet	Peir-Haur Hung Yung-Chien Hsu Tsung-Hsien Chen Chun-Liang Lin
author_sort	Peir-Haur Hung
title	Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
title_short	Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
title_full	Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
title_fullStr	Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
title_full_unstemmed	Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
title_sort	recent advances in diabetic kidney diseases: from kidney injury to kidney fibrosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cc0514a49ee045d9a98e90d36eec68ca
work_keys_str_mv	AT peirhaurhung recentadvancesindiabetickidneydiseasesfromkidneyinjurytokidneyfibrosis AT yungchienhsu recentadvancesindiabetickidneydiseasesfromkidneyinjurytokidneyfibrosis AT tsunghsienchen recentadvancesindiabetickidneydiseasesfromkidneyinjurytokidneyfibrosis AT chunlianglin recentadvancesindiabetickidneydiseasesfromkidneyinjurytokidneyfibrosis
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Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

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