An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks

Virus-related mortality and morbidity are due to cell/tissue damage caused by replicative pressure and resource exhaustion, e.g., HBV or HIV; exaggerated immune responses, e.g., SARS-CoV-2; and cancer, e.g., EBV or HPV. In this context, oncogenic and other types of viruses drive genetic and epigenet...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jenny Paola Alfaro-García, María Camila Granados-Alzate, Miguel Vicente-Manzanares, Juan Carlos Gallego-Gómez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cellular plasticity epithelial–mesenchymal transition systems biology Boolean viral infection Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cc05584a1b6043d4818ede378cc49fe1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cc05584a1b6043d4818ede378cc49fe1
record_format	dspace
spelling	oai:doaj.org-article:cc05584a1b6043d4818ede378cc49fe12021-11-25T17:08:12ZAn Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks10.3390/cells101128632073-4409https://doaj.org/article/cc05584a1b6043d4818ede378cc49fe12021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2863https://doaj.org/toc/2073-4409Virus-related mortality and morbidity are due to cell/tissue damage caused by replicative pressure and resource exhaustion, e.g., HBV or HIV; exaggerated immune responses, e.g., SARS-CoV-2; and cancer, e.g., EBV or HPV. In this context, oncogenic and other types of viruses drive genetic and epigenetic changes that expand the tumorigenic program, including modifications to the ability of cancer cells to migrate. The best-characterized group of changes is collectively known as the epithelial–mesenchymal transition, or EMT. This is a complex phenomenon classically described using biochemistry, cell biology and genetics. However, these methods require enormous, often slow, efforts to identify and validate novel therapeutic targets. Systems biology can complement and accelerate discoveries in this field. One example of such an approach is Boolean networks, which make complex biological problems tractable by modeling data (“nodes”) connected by logical operators. Here, we focus on virus-induced cellular plasticity and cell reprogramming in mammals, and how Boolean networks could provide novel insights into the ability of some viruses to trigger uncontrolled cell proliferation and EMT, two key hallmarks of cancer.Jenny Paola Alfaro-GarcíaMaría Camila Granados-AlzateMiguel Vicente-ManzanaresJuan Carlos Gallego-GómezMDPI AGarticlecellular plasticityepithelial–mesenchymal transitionsystems biologyBooleanviral infectionBiology (General)QH301-705.5ENCells, Vol 10, Iss 2863, p 2863 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cellular plasticity epithelial–mesenchymal transition systems biology Boolean viral infection Biology (General) QH301-705.5
spellingShingle	cellular plasticity epithelial–mesenchymal transition systems biology Boolean viral infection Biology (General) QH301-705.5 Jenny Paola Alfaro-García María Camila Granados-Alzate Miguel Vicente-Manzanares Juan Carlos Gallego-Gómez An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks
description	Virus-related mortality and morbidity are due to cell/tissue damage caused by replicative pressure and resource exhaustion, e.g., HBV or HIV; exaggerated immune responses, e.g., SARS-CoV-2; and cancer, e.g., EBV or HPV. In this context, oncogenic and other types of viruses drive genetic and epigenetic changes that expand the tumorigenic program, including modifications to the ability of cancer cells to migrate. The best-characterized group of changes is collectively known as the epithelial–mesenchymal transition, or EMT. This is a complex phenomenon classically described using biochemistry, cell biology and genetics. However, these methods require enormous, often slow, efforts to identify and validate novel therapeutic targets. Systems biology can complement and accelerate discoveries in this field. One example of such an approach is Boolean networks, which make complex biological problems tractable by modeling data (“nodes”) connected by logical operators. Here, we focus on virus-induced cellular plasticity and cell reprogramming in mammals, and how Boolean networks could provide novel insights into the ability of some viruses to trigger uncontrolled cell proliferation and EMT, two key hallmarks of cancer.
format	article
author	Jenny Paola Alfaro-García María Camila Granados-Alzate Miguel Vicente-Manzanares Juan Carlos Gallego-Gómez
author_facet	Jenny Paola Alfaro-García María Camila Granados-Alzate Miguel Vicente-Manzanares Juan Carlos Gallego-Gómez
author_sort	Jenny Paola Alfaro-García
title	An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks
title_short	An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks
title_full	An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks
title_fullStr	An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks
title_full_unstemmed	An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks
title_sort	integrated view of virus-triggered cellular plasticity using boolean networks
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cc05584a1b6043d4818ede378cc49fe1
work_keys_str_mv	AT jennypaolaalfarogarcia anintegratedviewofvirustriggeredcellularplasticityusingbooleannetworks AT mariacamilagranadosalzate anintegratedviewofvirustriggeredcellularplasticityusingbooleannetworks AT miguelvicentemanzanares anintegratedviewofvirustriggeredcellularplasticityusingbooleannetworks AT juancarlosgallegogomez anintegratedviewofvirustriggeredcellularplasticityusingbooleannetworks AT jennypaolaalfarogarcia integratedviewofvirustriggeredcellularplasticityusingbooleannetworks AT mariacamilagranadosalzate integratedviewofvirustriggeredcellularplasticityusingbooleannetworks AT miguelvicentemanzanares integratedviewofvirustriggeredcellularplasticityusingbooleannetworks AT juancarlosgallegogomez integratedviewofvirustriggeredcellularplasticityusingbooleannetworks
_version_	1718412741553684480

An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks

Ejemplares similares