Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids

Abstract Some obese subjects overeat lipid-rich foods. The origin of this eating behavior is unknown. We have here tested the hypothesis that these subjects could be characterized by an impaired fatty taste sensitivity linked to a change in the gustatory papillae microbial and salivary environment....

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Autores principales:	Philippe Besnard, Jeffrey E. Christensen, Hélène Brignot, Arnaud Bernard, Patricia Passilly-Degrace, Sophie Nicklaus, Jean-Paul Pais de Barros, Xavier Collet, Benjamin Lelouvier, Florence Servant, Vincent Blasco-Baque, Bruno Verges, Laurent Lagrost, Gilles Feron, Rémy Burcelin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc05726321ae4cad90ddb6bf339dc04b
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spelling	oai:doaj.org-article:cc05726321ae4cad90ddb6bf339dc04b2021-12-02T15:08:24ZObese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids10.1038/s41598-018-24619-12045-2322https://doaj.org/article/cc05726321ae4cad90ddb6bf339dc04b2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24619-1https://doaj.org/toc/2045-2322Abstract Some obese subjects overeat lipid-rich foods. The origin of this eating behavior is unknown. We have here tested the hypothesis that these subjects could be characterized by an impaired fatty taste sensitivity linked to a change in the gustatory papillae microbial and salivary environment. The composition of microbiota and saliva surrounding the circumvallate papillae was analyzed in combination with the orosensory lipid detection threshold in normal weight (NW) and obese (O) adults. Microbial architecture was similar to what was known in feces, but with an increased frequency of Proteobacteria. No difference in the orosensory sensitivity to lipids and composition of oral microbiota and saliva was observed between NW and O subjects. By contrast, specific bacterial and salivary signatures were found in lipid non-tasters, irrespectively of BMI. A multivariate approach highlighted that the salivary flow, lysozyme activity, total antioxidant capacity and TM7 bacterial family discriminated between tasters and non-tasters. Subgroup analysis of obese tasters (OT) versus obese non-tasters (ONT) identified specific bacterial metabolic pathways (i.e. phosphotransferase and simple sugar transport systems) as being higher in ONT. Altogether with the identification of a set of significant salivary variables, our study suggests that an “obese tongue” phenotype is associated with decreased orosensory sensitivity to lipids in some obese subjects.Philippe BesnardJeffrey E. ChristensenHélène BrignotArnaud BernardPatricia Passilly-DegraceSophie NicklausJean-Paul Pais de BarrosXavier ColletBenjamin LelouvierFlorence ServantVincent Blasco-BaqueBruno VergesLaurent LagrostGilles FeronRémy BurcelinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philippe Besnard Jeffrey E. Christensen Hélène Brignot Arnaud Bernard Patricia Passilly-Degrace Sophie Nicklaus Jean-Paul Pais de Barros Xavier Collet Benjamin Lelouvier Florence Servant Vincent Blasco-Baque Bruno Verges Laurent Lagrost Gilles Feron Rémy Burcelin Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids
description	Abstract Some obese subjects overeat lipid-rich foods. The origin of this eating behavior is unknown. We have here tested the hypothesis that these subjects could be characterized by an impaired fatty taste sensitivity linked to a change in the gustatory papillae microbial and salivary environment. The composition of microbiota and saliva surrounding the circumvallate papillae was analyzed in combination with the orosensory lipid detection threshold in normal weight (NW) and obese (O) adults. Microbial architecture was similar to what was known in feces, but with an increased frequency of Proteobacteria. No difference in the orosensory sensitivity to lipids and composition of oral microbiota and saliva was observed between NW and O subjects. By contrast, specific bacterial and salivary signatures were found in lipid non-tasters, irrespectively of BMI. A multivariate approach highlighted that the salivary flow, lysozyme activity, total antioxidant capacity and TM7 bacterial family discriminated between tasters and non-tasters. Subgroup analysis of obese tasters (OT) versus obese non-tasters (ONT) identified specific bacterial metabolic pathways (i.e. phosphotransferase and simple sugar transport systems) as being higher in ONT. Altogether with the identification of a set of significant salivary variables, our study suggests that an “obese tongue” phenotype is associated with decreased orosensory sensitivity to lipids in some obese subjects.
format	article
author	Philippe Besnard Jeffrey E. Christensen Hélène Brignot Arnaud Bernard Patricia Passilly-Degrace Sophie Nicklaus Jean-Paul Pais de Barros Xavier Collet Benjamin Lelouvier Florence Servant Vincent Blasco-Baque Bruno Verges Laurent Lagrost Gilles Feron Rémy Burcelin
author_facet	Philippe Besnard Jeffrey E. Christensen Hélène Brignot Arnaud Bernard Patricia Passilly-Degrace Sophie Nicklaus Jean-Paul Pais de Barros Xavier Collet Benjamin Lelouvier Florence Servant Vincent Blasco-Baque Bruno Verges Laurent Lagrost Gilles Feron Rémy Burcelin
author_sort	Philippe Besnard
title	Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids
title_short	Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids
title_full	Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids
title_fullStr	Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids
title_full_unstemmed	Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids
title_sort	obese subjects with specific gustatory papillae microbiota and salivary cues display an impairment to sense lipids
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cc05726321ae4cad90ddb6bf339dc04b
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Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids

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