A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing

Previous studies suggest that DNA methylation is the main mechanism to silence endogenous retroviruses (ERVs) in somatic cells. Here the authors provide evidence that distinctive sets of ERVs are silenced by Setdb1 in different types of somatic cells, suggesting a general function in ERV silencing.

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Autores principales:	Masaki Kato, Keiko Takemoto, Yoichi Shinkai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc0731fe6d5a4eed89c9169bcf9c60b8
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spelling	oai:doaj.org-article:cc0731fe6d5a4eed89c9169bcf9c60b82021-12-02T15:34:28ZA somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing10.1038/s41467-018-04132-92041-1723https://doaj.org/article/cc0731fe6d5a4eed89c9169bcf9c60b82018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04132-9https://doaj.org/toc/2041-1723Previous studies suggest that DNA methylation is the main mechanism to silence endogenous retroviruses (ERVs) in somatic cells. Here the authors provide evidence that distinctive sets of ERVs are silenced by Setdb1 in different types of somatic cells, suggesting a general function in ERV silencing.Masaki KatoKeiko TakemotoYoichi ShinkaiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masaki Kato Keiko Takemoto Yoichi Shinkai A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
description	Previous studies suggest that DNA methylation is the main mechanism to silence endogenous retroviruses (ERVs) in somatic cells. Here the authors provide evidence that distinctive sets of ERVs are silenced by Setdb1 in different types of somatic cells, suggesting a general function in ERV silencing.
format	article
author	Masaki Kato Keiko Takemoto Yoichi Shinkai
author_facet	Masaki Kato Keiko Takemoto Yoichi Shinkai
author_sort	Masaki Kato
title	A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
title_short	A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
title_full	A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
title_fullStr	A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
title_full_unstemmed	A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
title_sort	somatic role for the histone methyltransferase setdb1 in endogenous retrovirus silencing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cc0731fe6d5a4eed89c9169bcf9c60b8
work_keys_str_mv	AT masakikato asomaticroleforthehistonemethyltransferasesetdb1inendogenousretrovirussilencing AT keikotakemoto asomaticroleforthehistonemethyltransferasesetdb1inendogenousretrovirussilencing AT yoichishinkai asomaticroleforthehistonemethyltransferasesetdb1inendogenousretrovirussilencing AT masakikato somaticroleforthehistonemethyltransferasesetdb1inendogenousretrovirussilencing AT keikotakemoto somaticroleforthehistonemethyltransferasesetdb1inendogenousretrovirussilencing AT yoichishinkai somaticroleforthehistonemethyltransferasesetdb1inendogenousretrovirussilencing
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A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing

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