Circadian regulation of metabolic homeostasis: causes and consequences

Graham R McGinnis, Martin E Young Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: Robust circadian rhythms in metabolic processes have been described in both humans and animal models, at the whole body, individua...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	McGinnis GR, Young ME
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Circadian clock metabolism neurohumoral factors Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/cc08e180591c4df896533e8ad564a10f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cc08e180591c4df896533e8ad564a10f
record_format	dspace
spelling	oai:doaj.org-article:cc08e180591c4df896533e8ad564a10f2021-12-02T03:26:41ZCircadian regulation of metabolic homeostasis: causes and consequences1179-1608https://doaj.org/article/cc08e180591c4df896533e8ad564a10f2016-05-01T00:00:00Zhttps://www.dovepress.com/circadian-regulation-of-metabolic-homeostasis-causes-and-consequences-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Graham R McGinnis, Martin E Young Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: Robust circadian rhythms in metabolic processes have been described in both humans and animal models, at the whole body, individual organ, and even cellular level. Classically, these time-of-day-dependent rhythms have been considered secondary to fluctuations in energy/nutrient supply/demand associated with feeding/fasting and wake/sleep cycles. Renewed interest in this field has been fueled by studies revealing that these rhythms are driven, at least in part, by intrinsic mechanisms and that disruption of metabolic synchrony invariably increases the risk of cardiometabolic disease. The objectives of this paper are to provide a comprehensive review regarding rhythms in glucose, lipid, and protein/amino acid metabolism, the relative influence of extrinsic (eg, neurohumoral factors) versus intrinsic (eg, cell autonomous circadian clocks) mediators, the physiologic roles of these rhythms in terms of daily fluctuations in nutrient availability and activity status, as well as the pathologic consequences of dyssynchrony. Keywords: circadian rhythm, circadian clocks, metabolic homeostasis, neurohumoral factors, dyssynchrony, time-of-day-dependent rhythmsMcGinnis GRYoung MEDove Medical PressarticleCircadian clockmetabolismneurohumoral factorsPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2016, Iss Issue 1, Pp 163-180 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Circadian clock metabolism neurohumoral factors Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Circadian clock metabolism neurohumoral factors Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 McGinnis GR Young ME Circadian regulation of metabolic homeostasis: causes and consequences
description	Graham R McGinnis, Martin E Young Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: Robust circadian rhythms in metabolic processes have been described in both humans and animal models, at the whole body, individual organ, and even cellular level. Classically, these time-of-day-dependent rhythms have been considered secondary to fluctuations in energy/nutrient supply/demand associated with feeding/fasting and wake/sleep cycles. Renewed interest in this field has been fueled by studies revealing that these rhythms are driven, at least in part, by intrinsic mechanisms and that disruption of metabolic synchrony invariably increases the risk of cardiometabolic disease. The objectives of this paper are to provide a comprehensive review regarding rhythms in glucose, lipid, and protein/amino acid metabolism, the relative influence of extrinsic (eg, neurohumoral factors) versus intrinsic (eg, cell autonomous circadian clocks) mediators, the physiologic roles of these rhythms in terms of daily fluctuations in nutrient availability and activity status, as well as the pathologic consequences of dyssynchrony. Keywords: circadian rhythm, circadian clocks, metabolic homeostasis, neurohumoral factors, dyssynchrony, time-of-day-dependent rhythms
format	article
author	McGinnis GR Young ME
author_facet	McGinnis GR Young ME
author_sort	McGinnis GR
title	Circadian regulation of metabolic homeostasis: causes and consequences
title_short	Circadian regulation of metabolic homeostasis: causes and consequences
title_full	Circadian regulation of metabolic homeostasis: causes and consequences
title_fullStr	Circadian regulation of metabolic homeostasis: causes and consequences
title_full_unstemmed	Circadian regulation of metabolic homeostasis: causes and consequences
title_sort	circadian regulation of metabolic homeostasis: causes and consequences
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/cc08e180591c4df896533e8ad564a10f
work_keys_str_mv	AT mcginnisgr circadianregulationofmetabolichomeostasiscausesandconsequences AT youngme circadianregulationofmetabolichomeostasiscausesandconsequences
_version_	1718401759394660352

Circadian regulation of metabolic homeostasis: causes and consequences

Ejemplares similares