Genome-wide linkage and association analysis identifies major gene loci for guttural pouch tympany in Arabian and German warmblood horses.

Equine guttural pouch tympany (GPT) is a hereditary condition affecting foals in their first months of life. Complex segregation analyses in Arabian and German warmblood horses showed the involvement of a major gene as very likely. Genome-wide linkage and association analyses including a high densit...

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Autores principales:	Julia Metzger, Bernhard Ohnesorge, Ottmar Distl
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc0bd792140848dd824bfba31cda6a9c
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spelling	oai:doaj.org-article:cc0bd792140848dd824bfba31cda6a9c2021-11-18T07:10:43ZGenome-wide linkage and association analysis identifies major gene loci for guttural pouch tympany in Arabian and German warmblood horses.1932-620310.1371/journal.pone.0041640https://doaj.org/article/cc0bd792140848dd824bfba31cda6a9c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22848553/?tool=EBIhttps://doaj.org/toc/1932-6203Equine guttural pouch tympany (GPT) is a hereditary condition affecting foals in their first months of life. Complex segregation analyses in Arabian and German warmblood horses showed the involvement of a major gene as very likely. Genome-wide linkage and association analyses including a high density marker set of single nucleotide polymorphisms (SNPs) were performed to map the genomic region harbouring the potential major gene for GPT. A total of 85 Arabian and 373 German warmblood horses were genotyped on the Illumina equine SNP50 beadchip. Non-parametric multipoint linkage analyses showed genome-wide significance on horse chromosomes (ECA) 3 for German warmblood at 16-26 Mb and 34-55 Mb and for Arabian on ECA15 at 64-65 Mb. Genome-wide association analyses confirmed the linked regions for both breeds. In Arabian, genome-wide association was detected at 64 Mb within the region with the highest linkage peak on ECA15. For German warmblood, signals for genome-wide association were close to the peak region of linkage at 52 Mb on ECA3. The odds ratio for the SNP with the highest genome-wide association was 0.12 for the Arabian. In conclusion, the refinement of the regions with the Illumina equine SNP50 beadchip is an important step to unravel the responsible mutations for GPT.Julia MetzgerBernhard OhnesorgeOttmar DistlPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41640 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia Metzger Bernhard Ohnesorge Ottmar Distl Genome-wide linkage and association analysis identifies major gene loci for guttural pouch tympany in Arabian and German warmblood horses.
description	Equine guttural pouch tympany (GPT) is a hereditary condition affecting foals in their first months of life. Complex segregation analyses in Arabian and German warmblood horses showed the involvement of a major gene as very likely. Genome-wide linkage and association analyses including a high density marker set of single nucleotide polymorphisms (SNPs) were performed to map the genomic region harbouring the potential major gene for GPT. A total of 85 Arabian and 373 German warmblood horses were genotyped on the Illumina equine SNP50 beadchip. Non-parametric multipoint linkage analyses showed genome-wide significance on horse chromosomes (ECA) 3 for German warmblood at 16-26 Mb and 34-55 Mb and for Arabian on ECA15 at 64-65 Mb. Genome-wide association analyses confirmed the linked regions for both breeds. In Arabian, genome-wide association was detected at 64 Mb within the region with the highest linkage peak on ECA15. For German warmblood, signals for genome-wide association were close to the peak region of linkage at 52 Mb on ECA3. The odds ratio for the SNP with the highest genome-wide association was 0.12 for the Arabian. In conclusion, the refinement of the regions with the Illumina equine SNP50 beadchip is an important step to unravel the responsible mutations for GPT.
format	article
author	Julia Metzger Bernhard Ohnesorge Ottmar Distl
author_facet	Julia Metzger Bernhard Ohnesorge Ottmar Distl
author_sort	Julia Metzger
title	Genome-wide linkage and association analysis identifies major gene loci for guttural pouch tympany in Arabian and German warmblood horses.
title_short	Genome-wide linkage and association analysis identifies major gene loci for guttural pouch tympany in Arabian and German warmblood horses.
title_full	Genome-wide linkage and association analysis identifies major gene loci for guttural pouch tympany in Arabian and German warmblood horses.
title_fullStr	Genome-wide linkage and association analysis identifies major gene loci for guttural pouch tympany in Arabian and German warmblood horses.
title_full_unstemmed	Genome-wide linkage and association analysis identifies major gene loci for guttural pouch tympany in Arabian and German warmblood horses.
title_sort	genome-wide linkage and association analysis identifies major gene loci for guttural pouch tympany in arabian and german warmblood horses.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/cc0bd792140848dd824bfba31cda6a9c
work_keys_str_mv	AT juliametzger genomewidelinkageandassociationanalysisidentifiesmajorgenelociforgutturalpouchtympanyinarabianandgermanwarmbloodhorses AT bernhardohnesorge genomewidelinkageandassociationanalysisidentifiesmajorgenelociforgutturalpouchtympanyinarabianandgermanwarmbloodhorses AT ottmardistl genomewidelinkageandassociationanalysisidentifiesmajorgenelociforgutturalpouchtympanyinarabianandgermanwarmbloodhorses
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Genome-wide linkage and association analysis identifies major gene loci for guttural pouch tympany in Arabian and German warmblood horses.

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