BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level a...

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Autores principales:	Giuseppina D’Alessandro, Donna Rose Whelan, Sean Michael Howard, Valerio Vitelli, Xavier Renaudin, Marek Adamowicz, Fabio Iannelli, Corey Winston Jones-Weinert, MiYoung Lee, Valentina Matti, Wei Ting C. Lee, Michael John Morten, Ashok Raraakrishnan Venkitaraman, Petr Cejka, Eli Rothenberg, Fabrizio d’Adda di Fagagna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc0c69fc66a743848c9213f81e369d2a
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spelling	oai:doaj.org-article:cc0c69fc66a743848c9213f81e369d2a2021-12-02T16:56:59ZBRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment10.1038/s41467-018-07799-22041-1723https://doaj.org/article/cc0c69fc66a743848c9213f81e369d2a2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07799-2https://doaj.org/toc/2041-1723Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs.Giuseppina D’AlessandroDonna Rose WhelanSean Michael HowardValerio VitelliXavier RenaudinMarek AdamowiczFabio IannelliCorey Winston Jones-WeinertMiYoung LeeValentina MattiWei Ting C. LeeMichael John MortenAshok Raraakrishnan VenkitaramanPetr CejkaEli RothenbergFabrizio d’Adda di FagagnaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giuseppina D’Alessandro Donna Rose Whelan Sean Michael Howard Valerio Vitelli Xavier Renaudin Marek Adamowicz Fabio Iannelli Corey Winston Jones-Weinert MiYoung Lee Valentina Matti Wei Ting C. Lee Michael John Morten Ashok Raraakrishnan Venkitaraman Petr Cejka Eli Rothenberg Fabrizio d’Adda di Fagagna BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
description	Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs.
format	article
author	Giuseppina D’Alessandro Donna Rose Whelan Sean Michael Howard Valerio Vitelli Xavier Renaudin Marek Adamowicz Fabio Iannelli Corey Winston Jones-Weinert MiYoung Lee Valentina Matti Wei Ting C. Lee Michael John Morten Ashok Raraakrishnan Venkitaraman Petr Cejka Eli Rothenberg Fabrizio d’Adda di Fagagna
author_facet	Giuseppina D’Alessandro Donna Rose Whelan Sean Michael Howard Valerio Vitelli Xavier Renaudin Marek Adamowicz Fabio Iannelli Corey Winston Jones-Weinert MiYoung Lee Valentina Matti Wei Ting C. Lee Michael John Morten Ashok Raraakrishnan Venkitaraman Petr Cejka Eli Rothenberg Fabrizio d’Adda di Fagagna
author_sort	Giuseppina D’Alessandro
title	BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
title_short	BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
title_full	BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
title_fullStr	BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
title_full_unstemmed	BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
title_sort	brca2 controls dna:rna hybrid level at dsbs by mediating rnase h2 recruitment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cc0c69fc66a743848c9213f81e369d2a
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BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

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