BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level a...

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Auteurs principaux: Giuseppina D’Alessandro, Donna Rose Whelan, Sean Michael Howard, Valerio Vitelli, Xavier Renaudin, Marek Adamowicz, Fabio Iannelli, Corey Winston Jones-Weinert, MiYoung Lee, Valentina Matti, Wei Ting C. Lee, Michael John Morten, Ashok Raraakrishnan Venkitaraman, Petr Cejka, Eli Rothenberg, Fabrizio d’Adda di Fagagna
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Science
Q
Accès en ligne:https://doaj.org/article/cc0c69fc66a743848c9213f81e369d2a
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https://doaj.org/article/cc0c69fc66a743848c9213f81e369d2a

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