Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye

Juan Francisco Llamas-Moreno,1 Leopoldo Martín Baiza-Durán,1 Laura Ray Saucedo-Rodríguez,2 José Félix Alaníz-De la O21Clinical Research Department, Laboratorios Sophia, SA de CV Zapopan, Jalisco, México; 2Ophthalmology Depa...

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Autores principales:	Llamas-Moreno JF, Baiza-Dur&aacute;n LM, Saucedo-Rodr&iacute;guez LR, Alan&iacute;z-De la O JF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/cc0d57ffcfa74593a2cbcfe127e0f428
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spelling	oai:doaj.org-article:cc0d57ffcfa74593a2cbcfe127e0f4282021-12-02T00:53:15ZEfficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye1177-54671177-5483https://doaj.org/article/cc0d57ffcfa74593a2cbcfe127e0f4282013-05-01T00:00:00Zhttp://www.dovepress.com/efficacy-and-safety-of-chondroitin-sulfatexanthan-gum-versus-polyethyl-a13188https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Juan Francisco Llamas-Moreno,1 Leopoldo Martín Baiza-Durán,1 Laura Ray Saucedo-Rodríguez,2 José Félix Alaníz-De la O21Clinical Research Department, Laboratorios Sophia, SA de CV Zapopan, Jalisco, México; 2Ophthalmology Department, Fray Antonio Alcalde Hospital, Guadalajara, Jalisco, MéxicoPurpose: To evaluate the efficacy and safety of two ophthalmic solutions in patients with mild to moderate dry eye.Methods: We performed a prospective, 2-month-long, randomized, double-blind, single-center, parallel clinical trial to compare the efficacy and safety of two ophthalmic solutions for dry eye treatment. Patients were randomly assigned to one of the two treatment groups, study group or active-control group, and received one drop four times a day. The primary efficacy endpoint was to extend the tear film break-up time (TBUT) after 2 months of treatment. The Ocular Surface Disease Index (OSDI) was also evaluated. Safety measures were assessed by the presence of adverse events.Results: A total of 28 patients with mild to moderate dry eye were included in the per protocol analysis. TBUT was similar between groups at baseline (chondroitin sulfate and xanthan gum [CS/XG] group, 5.2 ± 2.3; Systane® group, 4.7 ± 2.6; P = 0.488), after 2 months of treatment, TBUT was still similar in both groups (CS/XG group, 6.1 ± 2.5; Systane® group, 7.3 ± 2.5; P = 0.088). Baseline OSDI was similar between the groups (CS/XG group, 18.8 ± 5.3; Systane® group, 19.8 ± 7.1; P = 0.810), but after 2 months of treatment, the OSDI was significantly lower in the CS/XG group (6.7 ± 5.7 versus 10.8 ± 6.4; P = 0.049). An adverse event was present in the CS/XG group, but it was not related to the treatment.Conclusions: In this population of patients with mild to moderate dry eye, treatment with CS/XG was as effective as treatment with Systane® with regard to TBUT; nevertheless, treatment in the CS/XG group was more effective at diminishing OSDI.Keywords: dry eye, efficacy, safety, TBUT, OSDILlamas-Moreno JFBaiza-Dur&aacute;n LMSaucedo-Rodr&iacute;guez LRAlan&iacute;z-De la O JFDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 995-999 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Llamas-Moreno JF Baiza-Dur&aacute;n LM Saucedo-Rodr&iacute;guez LR Alan&iacute;z-De la O JF Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye
description	Juan Francisco Llamas-Moreno,1 Leopoldo Martín Baiza-Durán,1 Laura Ray Saucedo-Rodríguez,2 José Félix Alaníz-De la O21Clinical Research Department, Laboratorios Sophia, SA de CV Zapopan, Jalisco, México; 2Ophthalmology Department, Fray Antonio Alcalde Hospital, Guadalajara, Jalisco, MéxicoPurpose: To evaluate the efficacy and safety of two ophthalmic solutions in patients with mild to moderate dry eye.Methods: We performed a prospective, 2-month-long, randomized, double-blind, single-center, parallel clinical trial to compare the efficacy and safety of two ophthalmic solutions for dry eye treatment. Patients were randomly assigned to one of the two treatment groups, study group or active-control group, and received one drop four times a day. The primary efficacy endpoint was to extend the tear film break-up time (TBUT) after 2 months of treatment. The Ocular Surface Disease Index (OSDI) was also evaluated. Safety measures were assessed by the presence of adverse events.Results: A total of 28 patients with mild to moderate dry eye were included in the per protocol analysis. TBUT was similar between groups at baseline (chondroitin sulfate and xanthan gum [CS/XG] group, 5.2 ± 2.3; Systane® group, 4.7 ± 2.6; P = 0.488), after 2 months of treatment, TBUT was still similar in both groups (CS/XG group, 6.1 ± 2.5; Systane® group, 7.3 ± 2.5; P = 0.088). Baseline OSDI was similar between the groups (CS/XG group, 18.8 ± 5.3; Systane® group, 19.8 ± 7.1; P = 0.810), but after 2 months of treatment, the OSDI was significantly lower in the CS/XG group (6.7 ± 5.7 versus 10.8 ± 6.4; P = 0.049). An adverse event was present in the CS/XG group, but it was not related to the treatment.Conclusions: In this population of patients with mild to moderate dry eye, treatment with CS/XG was as effective as treatment with Systane® with regard to TBUT; nevertheless, treatment in the CS/XG group was more effective at diminishing OSDI.Keywords: dry eye, efficacy, safety, TBUT, OSDI
format	article
author	Llamas-Moreno JF Baiza-Dur&aacute;n LM Saucedo-Rodr&iacute;guez LR Alan&iacute;z-De la O JF
author_facet	Llamas-Moreno JF Baiza-Dur&aacute;n LM Saucedo-Rodr&iacute;guez LR Alan&iacute;z-De la O JF
author_sort	Llamas-Moreno JF
title	Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye
title_short	Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye
title_full	Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye
title_fullStr	Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye
title_full_unstemmed	Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye
title_sort	efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/cc0d57ffcfa74593a2cbcfe127e0f428
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Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye

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