New noninvasive index for predicting liver fibrosis in Asian patients with chronic viral hepatitis

Abstract We developed an optimal noninvasive index comprising routine laboratory parameters for predicting cirrhosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) patients. This study included 992 CHB patients and 1,284 CHC patients who received liver biopsy. We developed the new index,...

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Autores principales:	Hung-Wei Wang, Cheng-Yuan Peng, Hsueh-Chou Lai, Wen-Pang Su, Chia-Hsin Lin, Po-Heng Chuang, Sheng-Hung Chen, Ching-Hsiang Chen, Wei-Fan Hsu, Guan-Tarn Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc1029e1a2ce4eee8fc4dfff953da495
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spelling	oai:doaj.org-article:cc1029e1a2ce4eee8fc4dfff953da4952021-12-02T11:40:33ZNew noninvasive index for predicting liver fibrosis in Asian patients with chronic viral hepatitis10.1038/s41598-017-03589-w2045-2322https://doaj.org/article/cc1029e1a2ce4eee8fc4dfff953da4952017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03589-whttps://doaj.org/toc/2045-2322Abstract We developed an optimal noninvasive index comprising routine laboratory parameters for predicting cirrhosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) patients. This study included 992 CHB patients and 1,284 CHC patients who received liver biopsy. We developed the new index, named modified Fibrosis-4 (mFIB-4) according to four independent variables of the model: age, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and platelet count. The formula of the mFIB-4 index is 10 × Age(years) × AST(U/L)/Platelet count(109/L) × ALT(U/L). For predicting cirrhosis, the bootstrap areas under the receiver operating characteristic curve for platelet count, AST/ALT ratio (AAR), AAR/platelet ratio index (AARPRI), AST/platelet ratio index (APRI), FIB-4, Pohl score, age-platelet (AP) index, Lok index, fibrosis quotient (FibroQ), and mFIB-4 were 0.7680, 0.7400, 0.8070, 0.6090, 0.7690, 0.6990, 0.7850, 0.7960, 0.8110, and 0.8070 in CHB patients, and 0.8170, 0.7210, 0.8400, 0.7310, 0.8310, 0.6730, 0.8220, 0.8440, 0.8570, and 0.8480 in CHC patients, respectively. FibroQ and mFIB-4 exhibited the highest diagnostic performance levels for liver cirrhosis in CHB and CHC despite the inclusion of the international normalised ratio in the formulation of FibroQ. Thus, mFIB-4 is a simple, inexpensive, and readily available method for assessing the liver fibrosis stage of Asian patients with CHB or CHC.Hung-Wei WangCheng-Yuan PengHsueh-Chou LaiWen-Pang SuChia-Hsin LinPo-Heng ChuangSheng-Hung ChenChing-Hsiang ChenWei-Fan HsuGuan-Tarn HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hung-Wei Wang Cheng-Yuan Peng Hsueh-Chou Lai Wen-Pang Su Chia-Hsin Lin Po-Heng Chuang Sheng-Hung Chen Ching-Hsiang Chen Wei-Fan Hsu Guan-Tarn Huang New noninvasive index for predicting liver fibrosis in Asian patients with chronic viral hepatitis
description	Abstract We developed an optimal noninvasive index comprising routine laboratory parameters for predicting cirrhosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) patients. This study included 992 CHB patients and 1,284 CHC patients who received liver biopsy. We developed the new index, named modified Fibrosis-4 (mFIB-4) according to four independent variables of the model: age, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and platelet count. The formula of the mFIB-4 index is 10 × Age(years) × AST(U/L)/Platelet count(109/L) × ALT(U/L). For predicting cirrhosis, the bootstrap areas under the receiver operating characteristic curve for platelet count, AST/ALT ratio (AAR), AAR/platelet ratio index (AARPRI), AST/platelet ratio index (APRI), FIB-4, Pohl score, age-platelet (AP) index, Lok index, fibrosis quotient (FibroQ), and mFIB-4 were 0.7680, 0.7400, 0.8070, 0.6090, 0.7690, 0.6990, 0.7850, 0.7960, 0.8110, and 0.8070 in CHB patients, and 0.8170, 0.7210, 0.8400, 0.7310, 0.8310, 0.6730, 0.8220, 0.8440, 0.8570, and 0.8480 in CHC patients, respectively. FibroQ and mFIB-4 exhibited the highest diagnostic performance levels for liver cirrhosis in CHB and CHC despite the inclusion of the international normalised ratio in the formulation of FibroQ. Thus, mFIB-4 is a simple, inexpensive, and readily available method for assessing the liver fibrosis stage of Asian patients with CHB or CHC.
format	article
author	Hung-Wei Wang Cheng-Yuan Peng Hsueh-Chou Lai Wen-Pang Su Chia-Hsin Lin Po-Heng Chuang Sheng-Hung Chen Ching-Hsiang Chen Wei-Fan Hsu Guan-Tarn Huang
author_facet	Hung-Wei Wang Cheng-Yuan Peng Hsueh-Chou Lai Wen-Pang Su Chia-Hsin Lin Po-Heng Chuang Sheng-Hung Chen Ching-Hsiang Chen Wei-Fan Hsu Guan-Tarn Huang
author_sort	Hung-Wei Wang
title	New noninvasive index for predicting liver fibrosis in Asian patients with chronic viral hepatitis
title_short	New noninvasive index for predicting liver fibrosis in Asian patients with chronic viral hepatitis
title_full	New noninvasive index for predicting liver fibrosis in Asian patients with chronic viral hepatitis
title_fullStr	New noninvasive index for predicting liver fibrosis in Asian patients with chronic viral hepatitis
title_full_unstemmed	New noninvasive index for predicting liver fibrosis in Asian patients with chronic viral hepatitis
title_sort	new noninvasive index for predicting liver fibrosis in asian patients with chronic viral hepatitis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cc1029e1a2ce4eee8fc4dfff953da495
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New noninvasive index for predicting liver fibrosis in Asian patients with chronic viral hepatitis

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