Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly

Asparaginyl-tRNA synthetase1 (NARS1) is required for protein synthesis. Here, the authors identify biallelic NARS1 mutations in individuals with microcephaly and neurodevelopmental delay. Cortical brain organoid modeling recapitulates microcephaly characteristics and scRNA-seq reveals a role for NAR...

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Autores principales:	Lu Wang, Zhen Li, David Sievert, Desirée E. C. Smith, Marisa I. Mendes, Dillon Y. Chen, Valentina Stanley, Shereen Ghosh, Yulu Wang, Majdi Kara, Ayca Dilruba Aslanger, Rasim O. Rosti, Henry Houlden, Gajja S. Salomons, Joseph G. Gleeson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc10dd5665ed408989d1b2eddc9acfe5
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spelling	oai:doaj.org-article:cc10dd5665ed408989d1b2eddc9acfe52021-12-02T16:28:07ZLoss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly10.1038/s41467-020-17454-42041-1723https://doaj.org/article/cc10dd5665ed408989d1b2eddc9acfe52020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17454-4https://doaj.org/toc/2041-1723Asparaginyl-tRNA synthetase1 (NARS1) is required for protein synthesis. Here, the authors identify biallelic NARS1 mutations in individuals with microcephaly and neurodevelopmental delay. Cortical brain organoid modeling recapitulates microcephaly characteristics and scRNA-seq reveals a role for NARS1 in radial glial cell proliferation.Lu WangZhen LiDavid SievertDesirée E. C. SmithMarisa I. MendesDillon Y. ChenValentina StanleyShereen GhoshYulu WangMajdi KaraAyca Dilruba AslangerRasim O. RostiHenry HouldenGajja S. SalomonsJoseph G. GleesonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Wang Zhen Li David Sievert Desirée E. C. Smith Marisa I. Mendes Dillon Y. Chen Valentina Stanley Shereen Ghosh Yulu Wang Majdi Kara Ayca Dilruba Aslanger Rasim O. Rosti Henry Houlden Gajja S. Salomons Joseph G. Gleeson Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly
description	Asparaginyl-tRNA synthetase1 (NARS1) is required for protein synthesis. Here, the authors identify biallelic NARS1 mutations in individuals with microcephaly and neurodevelopmental delay. Cortical brain organoid modeling recapitulates microcephaly characteristics and scRNA-seq reveals a role for NARS1 in radial glial cell proliferation.
format	article
author	Lu Wang Zhen Li David Sievert Desirée E. C. Smith Marisa I. Mendes Dillon Y. Chen Valentina Stanley Shereen Ghosh Yulu Wang Majdi Kara Ayca Dilruba Aslanger Rasim O. Rosti Henry Houlden Gajja S. Salomons Joseph G. Gleeson
author_facet	Lu Wang Zhen Li David Sievert Desirée E. C. Smith Marisa I. Mendes Dillon Y. Chen Valentina Stanley Shereen Ghosh Yulu Wang Majdi Kara Ayca Dilruba Aslanger Rasim O. Rosti Henry Houlden Gajja S. Salomons Joseph G. Gleeson
author_sort	Lu Wang
title	Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly
title_short	Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly
title_full	Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly
title_fullStr	Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly
title_full_unstemmed	Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly
title_sort	loss of nars1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cc10dd5665ed408989d1b2eddc9acfe5
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Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly

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