Robust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model

Abstract Circadian disruption resulting from exposure to irregular light–dark patterns and sleep deprivation has been associated with beta amyloid peptide (Aβ) aggregation, which is a major event in Alzheimer’s disease (AD) pathology. We exposed 5XFAD mice and littermate controls to dim-light vs. br...

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Autores principales:	Rohan Nagare, Bernard Possidente, Sarita Lagalwar, Mariana G. Figueiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc14f28708994586990708e7d9e1fb40
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spelling	oai:doaj.org-article:cc14f28708994586990708e7d9e1fb402021-12-02T16:24:49ZRobust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model10.1038/s41598-020-68199-52045-2322https://doaj.org/article/cc14f28708994586990708e7d9e1fb402020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68199-5https://doaj.org/toc/2045-2322Abstract Circadian disruption resulting from exposure to irregular light–dark patterns and sleep deprivation has been associated with beta amyloid peptide (Aβ) aggregation, which is a major event in Alzheimer’s disease (AD) pathology. We exposed 5XFAD mice and littermate controls to dim-light vs. bright-light photophases to investigate the effects of altering photophase strength on AD-associated differences in cortical Aβ42 levels, wheel-running activity, and circadian free-running period (tauDD). We found that increasing light levels significantly reduced cortical Aβ42 accumulation and activity levels during the light phase of the light:dark cycle, the latter being consistent with decreased sleep fragmentation and increased sleep duration for mice exposed to the more robust light–dark pattern. No significant changes were observed for tauDD. Our results are consistent with circadian pacemaker period being relatively unaffected by Aβ pathology in AD, and with reductions in cortical Aβ loads in AD through tailored lighting interventions.Rohan NagareBernard PossidenteSarita LagalwarMariana G. FigueiroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rohan Nagare Bernard Possidente Sarita Lagalwar Mariana G. Figueiro Robust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model
description	Abstract Circadian disruption resulting from exposure to irregular light–dark patterns and sleep deprivation has been associated with beta amyloid peptide (Aβ) aggregation, which is a major event in Alzheimer’s disease (AD) pathology. We exposed 5XFAD mice and littermate controls to dim-light vs. bright-light photophases to investigate the effects of altering photophase strength on AD-associated differences in cortical Aβ42 levels, wheel-running activity, and circadian free-running period (tauDD). We found that increasing light levels significantly reduced cortical Aβ42 accumulation and activity levels during the light phase of the light:dark cycle, the latter being consistent with decreased sleep fragmentation and increased sleep duration for mice exposed to the more robust light–dark pattern. No significant changes were observed for tauDD. Our results are consistent with circadian pacemaker period being relatively unaffected by Aβ pathology in AD, and with reductions in cortical Aβ loads in AD through tailored lighting interventions.
format	article
author	Rohan Nagare Bernard Possidente Sarita Lagalwar Mariana G. Figueiro
author_facet	Rohan Nagare Bernard Possidente Sarita Lagalwar Mariana G. Figueiro
author_sort	Rohan Nagare
title	Robust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model
title_short	Robust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model
title_full	Robust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model
title_fullStr	Robust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model
title_full_unstemmed	Robust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model
title_sort	robust light–dark patterns and reduced amyloid load in an alzheimer’s disease transgenic mouse model
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cc14f28708994586990708e7d9e1fb40
work_keys_str_mv	AT rohannagare robustlightdarkpatternsandreducedamyloidloadinanalzheimersdiseasetransgenicmousemodel AT bernardpossidente robustlightdarkpatternsandreducedamyloidloadinanalzheimersdiseasetransgenicmousemodel AT saritalagalwar robustlightdarkpatternsandreducedamyloidloadinanalzheimersdiseasetransgenicmousemodel AT marianagfigueiro robustlightdarkpatternsandreducedamyloidloadinanalzheimersdiseasetransgenicmousemodel
_version_	1718384137786621952

Robust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model

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