Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis

Failure to attenuate inflammation coupled with consequent microbiota changes drives the development of bone-destructive periodontitis. Quercetin, a plant-derived polyphenolic flavonoid, has been linked with health benefits in both humans and animals. Using a systematic approach, we investigated the...

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Autores principales:	Erin C. Mooney, Sara E. Holden, Xia-Juan Xia, Yajie Li, Min Jiang, Camille N. Banson, Bin Zhu, Sinem Esra Sahingur
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	flavonoids periodontal diseases IL-6 TNF A20 microbiome Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cc17adb1767643539d95693ef62e6c5c
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spelling	oai:doaj.org-article:cc17adb1767643539d95693ef62e6c5c2021-12-01T09:16:30ZQuercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis1664-322410.3389/fimmu.2021.774273https://doaj.org/article/cc17adb1767643539d95693ef62e6c5c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.774273/fullhttps://doaj.org/toc/1664-3224Failure to attenuate inflammation coupled with consequent microbiota changes drives the development of bone-destructive periodontitis. Quercetin, a plant-derived polyphenolic flavonoid, has been linked with health benefits in both humans and animals. Using a systematic approach, we investigated the effect of orally delivered Quercetin on host inflammatory response, oral microbial composition and periodontal disease phenotype. In vivo, quercetin supplementation diminished gingival cytokine expression, inflammatory cell infiltrate and alveolar bone loss. Microbiome analyses revealed a healthier oral microbial composition in Quercetin-treated versus vehicle-treated group characterized by reduction in the number of pathogenic species including Enterococcus, Neisseria and Pseudomonas and increase in the number of non-pathogenic Streptococcus sp. and bacterial diversity. In vitro, Quercetin diminished inflammatory cytokine production through modulating NF-κB:A20 axis in human macrophages following challenge with oral bacteria and TLR agonists. Collectively, our findings reveal that Quercetin supplement instigates a balanced periodontal tissue homeostasis through limiting inflammation and fostering an oral cavity microenvironment conducive of symbiotic microbiota associated with health. This proof of concept study provides key evidence for translational studies to improve overall health.Erin C. MooneyErin C. MooneySara E. HoldenXia-Juan XiaYajie LiMin JiangCamille N. BansonBin ZhuSinem Esra SahingurFrontiers Media S.A.articleflavonoidsperiodontal diseasesIL-6TNFA20microbiomeImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flavonoids periodontal diseases IL-6 TNF A20 microbiome Immunologic diseases. Allergy RC581-607
spellingShingle	flavonoids periodontal diseases IL-6 TNF A20 microbiome Immunologic diseases. Allergy RC581-607 Erin C. Mooney Erin C. Mooney Sara E. Holden Xia-Juan Xia Yajie Li Min Jiang Camille N. Banson Bin Zhu Sinem Esra Sahingur Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
description	Failure to attenuate inflammation coupled with consequent microbiota changes drives the development of bone-destructive periodontitis. Quercetin, a plant-derived polyphenolic flavonoid, has been linked with health benefits in both humans and animals. Using a systematic approach, we investigated the effect of orally delivered Quercetin on host inflammatory response, oral microbial composition and periodontal disease phenotype. In vivo, quercetin supplementation diminished gingival cytokine expression, inflammatory cell infiltrate and alveolar bone loss. Microbiome analyses revealed a healthier oral microbial composition in Quercetin-treated versus vehicle-treated group characterized by reduction in the number of pathogenic species including Enterococcus, Neisseria and Pseudomonas and increase in the number of non-pathogenic Streptococcus sp. and bacterial diversity. In vitro, Quercetin diminished inflammatory cytokine production through modulating NF-κB:A20 axis in human macrophages following challenge with oral bacteria and TLR agonists. Collectively, our findings reveal that Quercetin supplement instigates a balanced periodontal tissue homeostasis through limiting inflammation and fostering an oral cavity microenvironment conducive of symbiotic microbiota associated with health. This proof of concept study provides key evidence for translational studies to improve overall health.
format	article
author	Erin C. Mooney Erin C. Mooney Sara E. Holden Xia-Juan Xia Yajie Li Min Jiang Camille N. Banson Bin Zhu Sinem Esra Sahingur
author_facet	Erin C. Mooney Erin C. Mooney Sara E. Holden Xia-Juan Xia Yajie Li Min Jiang Camille N. Banson Bin Zhu Sinem Esra Sahingur
author_sort	Erin C. Mooney
title	Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title_short	Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title_full	Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title_fullStr	Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title_full_unstemmed	Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title_sort	quercetin preserves oral cavity health by mitigating inflammation and microbial dysbiosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cc17adb1767643539d95693ef62e6c5c
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Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis

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