Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis
Pathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new...
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Nature Portfolio
2017
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oai:doaj.org-article:cc1ca07b42ef444d8f0ceca3934d4c402021-12-02T14:41:18ZEndothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis10.1038/s41467-017-00551-22041-1723https://doaj.org/article/cc1ca07b42ef444d8f0ceca3934d4c402017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00551-2https://doaj.org/toc/2041-1723Pathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new therapeutic targets for disease treatment.Zhiping LiuSiyuan YanJiaojiao WangYiming XuYong WangShuya ZhangXizhen XuQiuhua YangXianqiu ZengYaqi ZhouXuejiao GuSarah LuZhongjie FuDavid J. FultonNeal L. WeintraubRuth B. CaldwellWenbo ZhangChaodong WuXiao-Ling LiuJiang-Fan ChenAftab AhmadIsmail Kaddour-DjebbarMohamed Al-ShabraweyQinkai LiXuejun JiangYe SunAkrit SodhiLois SmithMei HongYuqing HuoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Zhiping Liu Siyuan Yan Jiaojiao Wang Yiming Xu Yong Wang Shuya Zhang Xizhen Xu Qiuhua Yang Xianqiu Zeng Yaqi Zhou Xuejiao Gu Sarah Lu Zhongjie Fu David J. Fulton Neal L. Weintraub Ruth B. Caldwell Wenbo Zhang Chaodong Wu Xiao-Ling Liu Jiang-Fan Chen Aftab Ahmad Ismail Kaddour-Djebbar Mohamed Al-Shabrawey Qinkai Li Xuejun Jiang Ye Sun Akrit Sodhi Lois Smith Mei Hong Yuqing Huo Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| description |
Pathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new therapeutic targets for disease treatment. |
| format |
article |
| author |
Zhiping Liu Siyuan Yan Jiaojiao Wang Yiming Xu Yong Wang Shuya Zhang Xizhen Xu Qiuhua Yang Xianqiu Zeng Yaqi Zhou Xuejiao Gu Sarah Lu Zhongjie Fu David J. Fulton Neal L. Weintraub Ruth B. Caldwell Wenbo Zhang Chaodong Wu Xiao-Ling Liu Jiang-Fan Chen Aftab Ahmad Ismail Kaddour-Djebbar Mohamed Al-Shabrawey Qinkai Li Xuejun Jiang Ye Sun Akrit Sodhi Lois Smith Mei Hong Yuqing Huo |
| author_facet |
Zhiping Liu Siyuan Yan Jiaojiao Wang Yiming Xu Yong Wang Shuya Zhang Xizhen Xu Qiuhua Yang Xianqiu Zeng Yaqi Zhou Xuejiao Gu Sarah Lu Zhongjie Fu David J. Fulton Neal L. Weintraub Ruth B. Caldwell Wenbo Zhang Chaodong Wu Xiao-Ling Liu Jiang-Fan Chen Aftab Ahmad Ismail Kaddour-Djebbar Mohamed Al-Shabrawey Qinkai Li Xuejun Jiang Ye Sun Akrit Sodhi Lois Smith Mei Hong Yuqing Huo |
| author_sort |
Zhiping Liu |
| title |
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| title_short |
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| title_full |
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| title_fullStr |
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| title_full_unstemmed |
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| title_sort |
endothelial adenosine a2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/cc1ca07b42ef444d8f0ceca3934d4c40 |
| work_keys_str_mv |
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