Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen

Abstract To determine longitudinal changes in choriocapillaris (CC) measures in eyes with reticular pseudodrusen (RPD) using optical coherence tomography angiography (OCTA). In this observational prospective study, 20 patients with exclusively RPD and no other alteration due to age-related macular d...

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Autores principales:	Christoph R. Clemens, Jost L. Lauermann, Boris Schmitz, Nicole Eter, Florian Alten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc1f45188ad848c09aa7422d34f88b5b
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spelling	oai:doaj.org-article:cc1f45188ad848c09aa7422d34f88b5b2021-12-02T18:34:02ZLongitudinal choriocapillaris changes in the presence of reticular pseudodrusen10.1038/s41598-021-97771-w2045-2322https://doaj.org/article/cc1f45188ad848c09aa7422d34f88b5b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97771-whttps://doaj.org/toc/2045-2322Abstract To determine longitudinal changes in choriocapillaris (CC) measures in eyes with reticular pseudodrusen (RPD) using optical coherence tomography angiography (OCTA). In this observational prospective study, 20 patients with exclusively RPD and no other alteration due to age-related macular degeneration were included. Eight RPD patients were re-examined at 5-year follow-up. Multimodal imaging was performed at baseline and at 5-year follow-up. OCTA CC images were analyzed for number, size and total area of flow deficits (FD), mean signal intensity, signal intensity standard deviation and kurtosis of signal intensity distribution in the ring area between a circle of 4 mm diameter and a circle of 6 mm diameter and in the superior ring quadrant. Area affected by RPD increased from 19.36 ± 8.39 mm2 at baseline to 37.77 ± 9.03 mm2 at 5-year follow-up. At baseline, percent of CC FD area was greater in RPD eyes (quadrant: p < 0.001; ring: p < 0.001) compared to controls. Besides, RPD eyes revealed a lower mean intensity signal (quadrant: p < 0.001; ring: p < 0.001). Evaluation of CC parameters suggested significant group × time interaction effects for CC FD (p = 0.04) and mean intensity signal (p = 0.004), in that RPD eyes presented increased CC FD and decreased mean intensity signal at follow-up. OCTA CC decorrelation signal further decreases in RPD patients over 5 years in both RPD-affected and RPD-unaffected macular areas.Christoph R. ClemensJost L. LauermannBoris SchmitzNicole EterFlorian AltenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christoph R. Clemens Jost L. Lauermann Boris Schmitz Nicole Eter Florian Alten Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen
description	Abstract To determine longitudinal changes in choriocapillaris (CC) measures in eyes with reticular pseudodrusen (RPD) using optical coherence tomography angiography (OCTA). In this observational prospective study, 20 patients with exclusively RPD and no other alteration due to age-related macular degeneration were included. Eight RPD patients were re-examined at 5-year follow-up. Multimodal imaging was performed at baseline and at 5-year follow-up. OCTA CC images were analyzed for number, size and total area of flow deficits (FD), mean signal intensity, signal intensity standard deviation and kurtosis of signal intensity distribution in the ring area between a circle of 4 mm diameter and a circle of 6 mm diameter and in the superior ring quadrant. Area affected by RPD increased from 19.36 ± 8.39 mm2 at baseline to 37.77 ± 9.03 mm2 at 5-year follow-up. At baseline, percent of CC FD area was greater in RPD eyes (quadrant: p < 0.001; ring: p < 0.001) compared to controls. Besides, RPD eyes revealed a lower mean intensity signal (quadrant: p < 0.001; ring: p < 0.001). Evaluation of CC parameters suggested significant group × time interaction effects for CC FD (p = 0.04) and mean intensity signal (p = 0.004), in that RPD eyes presented increased CC FD and decreased mean intensity signal at follow-up. OCTA CC decorrelation signal further decreases in RPD patients over 5 years in both RPD-affected and RPD-unaffected macular areas.
format	article
author	Christoph R. Clemens Jost L. Lauermann Boris Schmitz Nicole Eter Florian Alten
author_facet	Christoph R. Clemens Jost L. Lauermann Boris Schmitz Nicole Eter Florian Alten
author_sort	Christoph R. Clemens
title	Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen
title_short	Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen
title_full	Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen
title_fullStr	Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen
title_full_unstemmed	Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen
title_sort	longitudinal choriocapillaris changes in the presence of reticular pseudodrusen
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cc1f45188ad848c09aa7422d34f88b5b
work_keys_str_mv	AT christophrclemens longitudinalchoriocapillarischangesinthepresenceofreticularpseudodrusen AT jostllauermann longitudinalchoriocapillarischangesinthepresenceofreticularpseudodrusen AT borisschmitz longitudinalchoriocapillarischangesinthepresenceofreticularpseudodrusen AT nicoleeter longitudinalchoriocapillarischangesinthepresenceofreticularpseudodrusen AT florianalten longitudinalchoriocapillarischangesinthepresenceofreticularpseudodrusen
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Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen

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