Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases
Abstract Airborne-mediated microbial diseases such as influenza and tuberculosis represent major public health challenges. A direct approach to prevent airborne transmission is inactivation of airborne pathogens, and the airborne antimicrobial potential of UVC ultraviolet light has long been establi...
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Nature Portfolio
2018
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oai:doaj.org-article:cc20fde75c8042879639596b631197b42021-12-02T11:40:46ZFar-UVC light: A new tool to control the spread of airborne-mediated microbial diseases10.1038/s41598-018-21058-w2045-2322https://doaj.org/article/cc20fde75c8042879639596b631197b42018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21058-whttps://doaj.org/toc/2045-2322Abstract Airborne-mediated microbial diseases such as influenza and tuberculosis represent major public health challenges. A direct approach to prevent airborne transmission is inactivation of airborne pathogens, and the airborne antimicrobial potential of UVC ultraviolet light has long been established; however, its widespread use in public settings is limited because conventional UVC light sources are both carcinogenic and cataractogenic. By contrast, we have previously shown that far-UVC light (207–222 nm) efficiently inactivates bacteria without harm to exposed mammalian skin. This is because, due to its strong absorbance in biological materials, far-UVC light cannot penetrate even the outer (non living) layers of human skin or eye; however, because bacteria and viruses are of micrometer or smaller dimensions, far-UVC can penetrate and inactivate them. We show for the first time that far-UVC efficiently inactivates airborne aerosolized viruses, with a very low dose of 2 mJ/cm2 of 222-nm light inactivating >95% of aerosolized H1N1 influenza virus. Continuous very low dose-rate far-UVC light in indoor public locations is a promising, safe and inexpensive tool to reduce the spread of airborne-mediated microbial diseases.David WelchManuela BuonannoVeljko GriljIgor ShuryakConnor CrickmoreAlan W. BigelowGerhard Randers-PehrsonGary W. JohnsonDavid J. BrennerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018) |
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Medicine R Science Q David Welch Manuela Buonanno Veljko Grilj Igor Shuryak Connor Crickmore Alan W. Bigelow Gerhard Randers-Pehrson Gary W. Johnson David J. Brenner Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases |
description |
Abstract Airborne-mediated microbial diseases such as influenza and tuberculosis represent major public health challenges. A direct approach to prevent airborne transmission is inactivation of airborne pathogens, and the airborne antimicrobial potential of UVC ultraviolet light has long been established; however, its widespread use in public settings is limited because conventional UVC light sources are both carcinogenic and cataractogenic. By contrast, we have previously shown that far-UVC light (207–222 nm) efficiently inactivates bacteria without harm to exposed mammalian skin. This is because, due to its strong absorbance in biological materials, far-UVC light cannot penetrate even the outer (non living) layers of human skin or eye; however, because bacteria and viruses are of micrometer or smaller dimensions, far-UVC can penetrate and inactivate them. We show for the first time that far-UVC efficiently inactivates airborne aerosolized viruses, with a very low dose of 2 mJ/cm2 of 222-nm light inactivating >95% of aerosolized H1N1 influenza virus. Continuous very low dose-rate far-UVC light in indoor public locations is a promising, safe and inexpensive tool to reduce the spread of airborne-mediated microbial diseases. |
format |
article |
author |
David Welch Manuela Buonanno Veljko Grilj Igor Shuryak Connor Crickmore Alan W. Bigelow Gerhard Randers-Pehrson Gary W. Johnson David J. Brenner |
author_facet |
David Welch Manuela Buonanno Veljko Grilj Igor Shuryak Connor Crickmore Alan W. Bigelow Gerhard Randers-Pehrson Gary W. Johnson David J. Brenner |
author_sort |
David Welch |
title |
Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases |
title_short |
Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases |
title_full |
Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases |
title_fullStr |
Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases |
title_full_unstemmed |
Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases |
title_sort |
far-uvc light: a new tool to control the spread of airborne-mediated microbial diseases |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/cc20fde75c8042879639596b631197b4 |
work_keys_str_mv |
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