Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice
Following peripheral nerve injury, influx of immune cells to the site may contribute to the development of chronic pain. Here the authors show that TRPA1 is expressed on Schwann cells and contributes to immune cell influx in a mouse model of neuropathic pain.
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Nature Portfolio
2017
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oai:doaj.org-article:cc21242beb744e37aeabdb35c1c9899c2021-12-02T15:38:59ZSchwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice10.1038/s41467-017-01739-22041-1723https://doaj.org/article/cc21242beb744e37aeabdb35c1c9899c2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01739-2https://doaj.org/toc/2041-1723Following peripheral nerve injury, influx of immune cells to the site may contribute to the development of chronic pain. Here the authors show that TRPA1 is expressed on Schwann cells and contributes to immune cell influx in a mouse model of neuropathic pain.Francesco De LoguRomina NassiniSerena MaterazziMuryel Carvalho GonçalvesDaniele NosiDuccio Rossi Degl’InnocentiIlaria M. MaroneJuliano FerreiraSimone Li PumaSilvia BenemeiGabriela TrevisanDaniel Souza Monteiro de AraújoRiccardo PatacchiniNigel W. BunnettPierangelo GeppettiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Francesco De Logu Romina Nassini Serena Materazzi Muryel Carvalho Gonçalves Daniele Nosi Duccio Rossi Degl’Innocenti Ilaria M. Marone Juliano Ferreira Simone Li Puma Silvia Benemei Gabriela Trevisan Daniel Souza Monteiro de Araújo Riccardo Patacchini Nigel W. Bunnett Pierangelo Geppetti Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice |
| description |
Following peripheral nerve injury, influx of immune cells to the site may contribute to the development of chronic pain. Here the authors show that TRPA1 is expressed on Schwann cells and contributes to immune cell influx in a mouse model of neuropathic pain. |
| format |
article |
| author |
Francesco De Logu Romina Nassini Serena Materazzi Muryel Carvalho Gonçalves Daniele Nosi Duccio Rossi Degl’Innocenti Ilaria M. Marone Juliano Ferreira Simone Li Puma Silvia Benemei Gabriela Trevisan Daniel Souza Monteiro de Araújo Riccardo Patacchini Nigel W. Bunnett Pierangelo Geppetti |
| author_facet |
Francesco De Logu Romina Nassini Serena Materazzi Muryel Carvalho Gonçalves Daniele Nosi Duccio Rossi Degl’Innocenti Ilaria M. Marone Juliano Ferreira Simone Li Puma Silvia Benemei Gabriela Trevisan Daniel Souza Monteiro de Araújo Riccardo Patacchini Nigel W. Bunnett Pierangelo Geppetti |
| author_sort |
Francesco De Logu |
| title |
Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice |
| title_short |
Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice |
| title_full |
Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice |
| title_fullStr |
Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice |
| title_full_unstemmed |
Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice |
| title_sort |
schwann cell trpa1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/cc21242beb744e37aeabdb35c1c9899c |
| work_keys_str_mv |
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