Potentials and limitations of microorganisms as renal failure biotherapeutics

Poonam Jain, Sapna Shah, Razek Coussa, Satya PrakashBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Qu&eacute;bec, CanadaAbstract: R...

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Autores principales:	Poonam Jain, Sapna Shah, Razek Coussa, Satya Prakash
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cc2530c4e2bc4eae98a416dc6a50cf24
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spelling	oai:doaj.org-article:cc2530c4e2bc4eae98a416dc6a50cf242021-12-02T07:14:51ZPotentials and limitations of microorganisms as renal failure biotherapeutics1177-54751177-5491https://doaj.org/article/cc2530c4e2bc4eae98a416dc6a50cf242009-05-01T00:00:00Zhttp://www.dovepress.com/potentials-and-limitations-of-microorganisms-as-renal-failure-biothera-a3140https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Poonam Jain, Sapna Shah, Razek Coussa, Satya PrakashBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Qu&eacute;bec, CanadaAbstract: Renal insufficiency leads to uremia, a complicated syndrome. It thus becomes vital to reduce waste metabolites and regulate water and electrolytes in kidney failure. The most common treatment of this disease is either dialysis or transplantation. Although these treatments are very effective, they are extremely costly. Recently artificial cells, microencapsulated live bacterial cells, and other cells have been studied to manage renal failure metabolic wastes. The procedure for microencapsulation of biologically active material is well documented and offers many biomedical applications. Microencapsulated bacteria have been documented to efficiently remove urea and several uremic markers such as ammonia, creatinine, uric acid, phosphate, potassium, magnesium, sodium, and chloride. These bacteria also have further potential as biotherapeutic agents because they can be engineered to remove selected unwanted waste. This application has enormous potential for removal of waste metabolites and electrolytes in renal failure as well as other diseases such as liver failure, phenylketonuria, and Crohn&rsquo;s disease, to name a few. This paper discusses the various options available to date to manage renal failure metabolites and focuses on the potential of using encapsulated live cells as biotherapeutic agents to control renal failure waste metabolites and electrolytes. Keywords: renal failure, microencapsulation, artificial cells, oral administration, bacterial cells, metabolites, electrolytes, polymeric membrane Poonam JainSapna ShahRazek CoussaSatya PrakashDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2009, Iss default, Pp 233-243 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Poonam Jain Sapna Shah Razek Coussa Satya Prakash Potentials and limitations of microorganisms as renal failure biotherapeutics
description	Poonam Jain, Sapna Shah, Razek Coussa, Satya PrakashBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Qu&eacute;bec, CanadaAbstract: Renal insufficiency leads to uremia, a complicated syndrome. It thus becomes vital to reduce waste metabolites and regulate water and electrolytes in kidney failure. The most common treatment of this disease is either dialysis or transplantation. Although these treatments are very effective, they are extremely costly. Recently artificial cells, microencapsulated live bacterial cells, and other cells have been studied to manage renal failure metabolic wastes. The procedure for microencapsulation of biologically active material is well documented and offers many biomedical applications. Microencapsulated bacteria have been documented to efficiently remove urea and several uremic markers such as ammonia, creatinine, uric acid, phosphate, potassium, magnesium, sodium, and chloride. These bacteria also have further potential as biotherapeutic agents because they can be engineered to remove selected unwanted waste. This application has enormous potential for removal of waste metabolites and electrolytes in renal failure as well as other diseases such as liver failure, phenylketonuria, and Crohn&rsquo;s disease, to name a few. This paper discusses the various options available to date to manage renal failure metabolites and focuses on the potential of using encapsulated live cells as biotherapeutic agents to control renal failure waste metabolites and electrolytes. Keywords: renal failure, microencapsulation, artificial cells, oral administration, bacterial cells, metabolites, electrolytes, polymeric membrane
format	article
author	Poonam Jain Sapna Shah Razek Coussa Satya Prakash
author_facet	Poonam Jain Sapna Shah Razek Coussa Satya Prakash
author_sort	Poonam Jain
title	Potentials and limitations of microorganisms as renal failure biotherapeutics
title_short	Potentials and limitations of microorganisms as renal failure biotherapeutics
title_full	Potentials and limitations of microorganisms as renal failure biotherapeutics
title_fullStr	Potentials and limitations of microorganisms as renal failure biotherapeutics
title_full_unstemmed	Potentials and limitations of microorganisms as renal failure biotherapeutics
title_sort	potentials and limitations of microorganisms as renal failure biotherapeutics
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/cc2530c4e2bc4eae98a416dc6a50cf24
work_keys_str_mv	AT poonamjain potentialsandlimitationsofmicroorganismsasrenalfailurebiotherapeutics AT sapnashah potentialsandlimitationsofmicroorganismsasrenalfailurebiotherapeutics AT razekcoussa potentialsandlimitationsofmicroorganismsasrenalfailurebiotherapeutics AT satyaprakash potentialsandlimitationsofmicroorganismsasrenalfailurebiotherapeutics
_version_	1718399542245720064

Potentials and limitations of microorganisms as renal failure biotherapeutics

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