Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands

The molecular mechanisms underlying retrograde transport in axons are only partially understood. Villarinet al. show that in cultured DRG neurons, extracellular trophic cues such as NGF dynamically regulate local protein synthesis of dynein cofactors, thus controlling retrograde trafficking in neuro...

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Autores principales:	Joseph M. Villarin, Ethan P. McCurdy, José C. Martínez, Ulrich Hengst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc2cfa3b845c4a8abe1fd6878230bc89
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spelling	oai:doaj.org-article:cc2cfa3b845c4a8abe1fd6878230bc892021-12-02T16:57:18ZLocal synthesis of dynein cofactors matches retrograde transport to acutely changing demands10.1038/ncomms138652041-1723https://doaj.org/article/cc2cfa3b845c4a8abe1fd6878230bc892016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13865https://doaj.org/toc/2041-1723The molecular mechanisms underlying retrograde transport in axons are only partially understood. Villarinet al. show that in cultured DRG neurons, extracellular trophic cues such as NGF dynamically regulate local protein synthesis of dynein cofactors, thus controlling retrograde trafficking in neurons.Joseph M. VillarinEthan P. McCurdyJosé C. MartínezUlrich HengstNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph M. Villarin Ethan P. McCurdy José C. Martínez Ulrich Hengst Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands
description	The molecular mechanisms underlying retrograde transport in axons are only partially understood. Villarinet al. show that in cultured DRG neurons, extracellular trophic cues such as NGF dynamically regulate local protein synthesis of dynein cofactors, thus controlling retrograde trafficking in neurons.
format	article
author	Joseph M. Villarin Ethan P. McCurdy José C. Martínez Ulrich Hengst
author_facet	Joseph M. Villarin Ethan P. McCurdy José C. Martínez Ulrich Hengst
author_sort	Joseph M. Villarin
title	Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands
title_short	Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands
title_full	Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands
title_fullStr	Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands
title_full_unstemmed	Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands
title_sort	local synthesis of dynein cofactors matches retrograde transport to acutely changing demands
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/cc2cfa3b845c4a8abe1fd6878230bc89
work_keys_str_mv	AT josephmvillarin localsynthesisofdyneincofactorsmatchesretrogradetransporttoacutelychangingdemands AT ethanpmccurdy localsynthesisofdyneincofactorsmatchesretrogradetransporttoacutelychangingdemands AT josecmartinez localsynthesisofdyneincofactorsmatchesretrogradetransporttoacutelychangingdemands AT ulrichhengst localsynthesisofdyneincofactorsmatchesretrogradetransporttoacutelychangingdemands
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Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands

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