Transcriptional Control of Apical-Basal Polarity Regulators

Cell polarity is essential for many functions of cells and tissues including the initial establishment and subsequent maintenance of epithelial tissues, asymmetric cell division, and morphogenetic movements. Cell polarity along the apical-basal axis is controlled by three protein complexes that inte...

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Auteurs principaux:	Katja Rust, Andreas Wodarz
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	cell polarity gene expression transcriptional regulation Par complex Scrib complex Crumbs complex Biology (General) QH301-705.5 Chemistry QD1-999
Accès en ligne:	https://doaj.org/article/cc2faa1018c747bdbda5a1054ce966d4
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id	oai:doaj.org-article:cc2faa1018c747bdbda5a1054ce966d4
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spelling	oai:doaj.org-article:cc2faa1018c747bdbda5a1054ce966d42021-11-25T17:55:34ZTranscriptional Control of Apical-Basal Polarity Regulators10.3390/ijms2222123401422-00671661-6596https://doaj.org/article/cc2faa1018c747bdbda5a1054ce966d42021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12340https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cell polarity is essential for many functions of cells and tissues including the initial establishment and subsequent maintenance of epithelial tissues, asymmetric cell division, and morphogenetic movements. Cell polarity along the apical-basal axis is controlled by three protein complexes that interact with and co-regulate each other: The Par-, Crumbs-, and Scrib-complexes. The localization and activity of the components of these complexes is predominantly controlled by protein-protein interactions and protein phosphorylation status. Increasing evidence accumulates that, besides the regulation at the protein level, the precise expression control of polarity determinants contributes substantially to cell polarity regulation. Here we review how gene expression regulation influences processes that depend on the induction, maintenance, or abolishment of cell polarity with a special focus on epithelial to mesenchymal transition and asymmetric stem cell division. We conclude that gene expression control is an important and often neglected mechanism in the control of cell polarity.Katja RustAndreas WodarzMDPI AGarticlecell polaritygene expressiontranscriptional regulationPar complexScrib complexCrumbs complexBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12340, p 12340 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell polarity gene expression transcriptional regulation Par complex Scrib complex Crumbs complex Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cell polarity gene expression transcriptional regulation Par complex Scrib complex Crumbs complex Biology (General) QH301-705.5 Chemistry QD1-999 Katja Rust Andreas Wodarz Transcriptional Control of Apical-Basal Polarity Regulators
description	Cell polarity is essential for many functions of cells and tissues including the initial establishment and subsequent maintenance of epithelial tissues, asymmetric cell division, and morphogenetic movements. Cell polarity along the apical-basal axis is controlled by three protein complexes that interact with and co-regulate each other: The Par-, Crumbs-, and Scrib-complexes. The localization and activity of the components of these complexes is predominantly controlled by protein-protein interactions and protein phosphorylation status. Increasing evidence accumulates that, besides the regulation at the protein level, the precise expression control of polarity determinants contributes substantially to cell polarity regulation. Here we review how gene expression regulation influences processes that depend on the induction, maintenance, or abolishment of cell polarity with a special focus on epithelial to mesenchymal transition and asymmetric stem cell division. We conclude that gene expression control is an important and often neglected mechanism in the control of cell polarity.
format	article
author	Katja Rust Andreas Wodarz
author_facet	Katja Rust Andreas Wodarz
author_sort	Katja Rust
title	Transcriptional Control of Apical-Basal Polarity Regulators
title_short	Transcriptional Control of Apical-Basal Polarity Regulators
title_full	Transcriptional Control of Apical-Basal Polarity Regulators
title_fullStr	Transcriptional Control of Apical-Basal Polarity Regulators
title_full_unstemmed	Transcriptional Control of Apical-Basal Polarity Regulators
title_sort	transcriptional control of apical-basal polarity regulators
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cc2faa1018c747bdbda5a1054ce966d4
work_keys_str_mv	AT katjarust transcriptionalcontrolofapicalbasalpolarityregulators AT andreaswodarz transcriptionalcontrolofapicalbasalpolarityregulators
_version_	1718411830300246016

Transcriptional Control of Apical-Basal Polarity Regulators

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