ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear. Here the authors show that endoplasmic reticulum (ER) tubules in the soma of neurons regulate lysosome localization and function by regulating...

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Autores principales:	Nazmiye Özkan, Max Koppers, Inge van Soest, Alexandra van Harten, Daphne Jurriens, Nalan Liv, Judith Klumperman, Lukas C. Kapitein, Casper C. Hoogenraad, Ginny G. Farías
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc342bac8e3b45b797d52c6e73112560
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spelling	oai:doaj.org-article:cc342bac8e3b45b797d52c6e731125602021-12-02T16:26:32ZER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability10.1038/s41467-021-24713-52041-1723https://doaj.org/article/cc342bac8e3b45b797d52c6e731125602021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24713-5https://doaj.org/toc/2041-1723In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear. Here the authors show that endoplasmic reticulum (ER) tubules in the soma of neurons regulate lysosome localization and function by regulating lysosomal fission, suggesting a role for ER – lysosome inter-organelle membrane contact sites in lysosomal axonal availability.Nazmiye ÖzkanMax KoppersInge van SoestAlexandra van HartenDaphne JurriensNalan LivJudith KlumpermanLukas C. KapiteinCasper C. HoogenraadGinny G. FaríasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nazmiye Özkan Max Koppers Inge van Soest Alexandra van Harten Daphne Jurriens Nalan Liv Judith Klumperman Lukas C. Kapitein Casper C. Hoogenraad Ginny G. Farías ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
description	In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear. Here the authors show that endoplasmic reticulum (ER) tubules in the soma of neurons regulate lysosome localization and function by regulating lysosomal fission, suggesting a role for ER – lysosome inter-organelle membrane contact sites in lysosomal axonal availability.
format	article
author	Nazmiye Özkan Max Koppers Inge van Soest Alexandra van Harten Daphne Jurriens Nalan Liv Judith Klumperman Lukas C. Kapitein Casper C. Hoogenraad Ginny G. Farías
author_facet	Nazmiye Özkan Max Koppers Inge van Soest Alexandra van Harten Daphne Jurriens Nalan Liv Judith Klumperman Lukas C. Kapitein Casper C. Hoogenraad Ginny G. Farías
author_sort	Nazmiye Özkan
title	ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
title_short	ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
title_full	ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
title_fullStr	ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
title_full_unstemmed	ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
title_sort	er – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cc342bac8e3b45b797d52c6e73112560
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_version_	1718384017768710144

ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

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