MAIT cells are activated during human viral infections
Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing interferon gamma and granzyme B.
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Nature Portfolio
2016
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oai:doaj.org-article:cc3459afe5a047aa8c5feb665511a1eb2021-12-02T15:35:01ZMAIT cells are activated during human viral infections10.1038/ncomms116532041-1723https://doaj.org/article/cc3459afe5a047aa8c5feb665511a1eb2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11653https://doaj.org/toc/2041-1723Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing interferon gamma and granzyme B.Bonnie van WilgenburgIris ScherwitzlEdward C. HutchinsonTianqi LengAyako KuriokaCorinna KulickeCatherine de LaraSuzanne ColeSirijitt VasanawathanaWannee LimpitikulPrida MalasitDuncan YoungLaura DenneySTOP-HCV consortiumMichael D. MoorePaolo FabrisMaria Teresa GiordaniYe Htun OoStephen M. LaidlawLynn B. DustinLing-Pei HoFiona M. ThompsonNarayan RamamurthyJuthathip MongkolsapayaChristian B. WillbergGavin R. ScreatonPaul KlenermanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Bonnie van Wilgenburg Iris Scherwitzl Edward C. Hutchinson Tianqi Leng Ayako Kurioka Corinna Kulicke Catherine de Lara Suzanne Cole Sirijitt Vasanawathana Wannee Limpitikul Prida Malasit Duncan Young Laura Denney STOP-HCV consortium Michael D. Moore Paolo Fabris Maria Teresa Giordani Ye Htun Oo Stephen M. Laidlaw Lynn B. Dustin Ling-Pei Ho Fiona M. Thompson Narayan Ramamurthy Juthathip Mongkolsapaya Christian B. Willberg Gavin R. Screaton Paul Klenerman MAIT cells are activated during human viral infections |
| description |
Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing interferon gamma and granzyme B. |
| format |
article |
| author |
Bonnie van Wilgenburg Iris Scherwitzl Edward C. Hutchinson Tianqi Leng Ayako Kurioka Corinna Kulicke Catherine de Lara Suzanne Cole Sirijitt Vasanawathana Wannee Limpitikul Prida Malasit Duncan Young Laura Denney STOP-HCV consortium Michael D. Moore Paolo Fabris Maria Teresa Giordani Ye Htun Oo Stephen M. Laidlaw Lynn B. Dustin Ling-Pei Ho Fiona M. Thompson Narayan Ramamurthy Juthathip Mongkolsapaya Christian B. Willberg Gavin R. Screaton Paul Klenerman |
| author_facet |
Bonnie van Wilgenburg Iris Scherwitzl Edward C. Hutchinson Tianqi Leng Ayako Kurioka Corinna Kulicke Catherine de Lara Suzanne Cole Sirijitt Vasanawathana Wannee Limpitikul Prida Malasit Duncan Young Laura Denney STOP-HCV consortium Michael D. Moore Paolo Fabris Maria Teresa Giordani Ye Htun Oo Stephen M. Laidlaw Lynn B. Dustin Ling-Pei Ho Fiona M. Thompson Narayan Ramamurthy Juthathip Mongkolsapaya Christian B. Willberg Gavin R. Screaton Paul Klenerman |
| author_sort |
Bonnie van Wilgenburg |
| title |
MAIT cells are activated during human viral infections |
| title_short |
MAIT cells are activated during human viral infections |
| title_full |
MAIT cells are activated during human viral infections |
| title_fullStr |
MAIT cells are activated during human viral infections |
| title_full_unstemmed |
MAIT cells are activated during human viral infections |
| title_sort |
mait cells are activated during human viral infections |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/cc3459afe5a047aa8c5feb665511a1eb |
| work_keys_str_mv |
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| _version_ |
1718386683983953920 |