Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction
Fas drives apoptosis and mutations in this receptor can cause autoimmunity through failure of cell death. Here, the authors uselpr/lprmice with palmitoylation-defective mutant Fas to provide evidence that Fas might limit spontaneous autoimmunity through a non-apoptotic mechanism.
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| Lenguaje: | EN |
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/cc383b006c164d3693b4b809cca1c231 |
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oai:doaj.org-article:cc383b006c164d3693b4b809cca1c2312021-12-02T14:40:15ZFas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction10.1038/ncomms138952041-1723https://doaj.org/article/cc383b006c164d3693b4b809cca1c2312016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13895https://doaj.org/toc/2041-1723Fas drives apoptosis and mutations in this receptor can cause autoimmunity through failure of cell death. Here, the authors uselpr/lprmice with palmitoylation-defective mutant Fas to provide evidence that Fas might limit spontaneous autoimmunity through a non-apoptotic mechanism.Anthony C. CruzMadhu RamaswamyClaudia OuyangChristopher A. KlebanoffPrabuddha SenguptaTori N. YamamotoFrançoise MeylanStacy K. ThomasNathan RichozRobert EilSusan PriceRafael CasellasV. Koneti RaoJennifer Lippincott-SchwartzNicholas P. RestifoRichard M. SiegelNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Anthony C. Cruz Madhu Ramaswamy Claudia Ouyang Christopher A. Klebanoff Prabuddha Sengupta Tori N. Yamamoto Françoise Meylan Stacy K. Thomas Nathan Richoz Robert Eil Susan Price Rafael Casellas V. Koneti Rao Jennifer Lippincott-Schwartz Nicholas P. Restifo Richard M. Siegel Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction |
| description |
Fas drives apoptosis and mutations in this receptor can cause autoimmunity through failure of cell death. Here, the authors uselpr/lprmice with palmitoylation-defective mutant Fas to provide evidence that Fas might limit spontaneous autoimmunity through a non-apoptotic mechanism. |
| format |
article |
| author |
Anthony C. Cruz Madhu Ramaswamy Claudia Ouyang Christopher A. Klebanoff Prabuddha Sengupta Tori N. Yamamoto Françoise Meylan Stacy K. Thomas Nathan Richoz Robert Eil Susan Price Rafael Casellas V. Koneti Rao Jennifer Lippincott-Schwartz Nicholas P. Restifo Richard M. Siegel |
| author_facet |
Anthony C. Cruz Madhu Ramaswamy Claudia Ouyang Christopher A. Klebanoff Prabuddha Sengupta Tori N. Yamamoto Françoise Meylan Stacy K. Thomas Nathan Richoz Robert Eil Susan Price Rafael Casellas V. Koneti Rao Jennifer Lippincott-Schwartz Nicholas P. Restifo Richard M. Siegel |
| author_sort |
Anthony C. Cruz |
| title |
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction |
| title_short |
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction |
| title_full |
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction |
| title_fullStr |
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction |
| title_full_unstemmed |
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction |
| title_sort |
fas/cd95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/cc383b006c164d3693b4b809cca1c231 |
| work_keys_str_mv |
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| _version_ |
1718390385914413056 |