Maternal age and risk of early neonatal mortality: a national cohort study

Abstract Advanced maternal age (AMA) is a growing trend world-wide and is traditionally defined as childbearing in women over 35 years of age. The purpose of our study was to determine the maternal age group within the Korean population, in which the risk of early neonatal mortality is increased. Ko...

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Autores principales:	Yoo-Na Kim, Dong-Woo Choi, Dong Seop Kim, Eun-Cheol Park, Ja-Young Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc3930340a1a4d70b4e68f83cc77e021
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spelling	oai:doaj.org-article:cc3930340a1a4d70b4e68f83cc77e0212021-12-02T14:12:41ZMaternal age and risk of early neonatal mortality: a national cohort study10.1038/s41598-021-80968-42045-2322https://doaj.org/article/cc3930340a1a4d70b4e68f83cc77e0212021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-80968-4https://doaj.org/toc/2045-2322Abstract Advanced maternal age (AMA) is a growing trend world-wide and is traditionally defined as childbearing in women over 35 years of age. The purpose of our study was to determine the maternal age group within the Korean population, in which the risk of early neonatal mortality is increased. Korean birth and mortality data from 2011 to 2015 were used to estimate the influence of maternal age on the risk of early neonatal mortality. A Poisson regression was used for the analysis of multiple clinical variables such as year of delivery, maternal age, gestational age, infant gender, birth weight, multiple birth, parity, and socioeconomic variables. Furthermore, a generalized additive model was used to determine the maternal age at which the risk for neonatal mortality increases. We included 2,161,908 participants and found that 49.4% of mothers were 30–34 years of age at delivery. The proportion of mothers aged 35 and above increased over the 5-year analysis period. A maternal age lower than 29 years or higher than 40 years was associated with a relatively higher risk of early neonatal mortality. The trend and magnitude of the age-related risk on early neonatal mortality were independent of maternal socioeconomic factors such as living in an obstetrically underserved area, education level, and employment status. Furthermore, we showed that the risk for early neonatal mortality was higher until the maternal age of 28. However, there were no significant changes in the risk between the age of 35 and 40 years. According to recent national-wide data, age-related risk for early neonatal mortality is only apparent for mothers ≥ 40 years old whereas, age between 35 and 39 are not at increased risk for early neonatal mortality, despite being classified as AMA.Yoo-Na KimDong-Woo ChoiDong Seop KimEun-Cheol ParkJa-Young KwonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoo-Na Kim Dong-Woo Choi Dong Seop Kim Eun-Cheol Park Ja-Young Kwon Maternal age and risk of early neonatal mortality: a national cohort study
description	Abstract Advanced maternal age (AMA) is a growing trend world-wide and is traditionally defined as childbearing in women over 35 years of age. The purpose of our study was to determine the maternal age group within the Korean population, in which the risk of early neonatal mortality is increased. Korean birth and mortality data from 2011 to 2015 were used to estimate the influence of maternal age on the risk of early neonatal mortality. A Poisson regression was used for the analysis of multiple clinical variables such as year of delivery, maternal age, gestational age, infant gender, birth weight, multiple birth, parity, and socioeconomic variables. Furthermore, a generalized additive model was used to determine the maternal age at which the risk for neonatal mortality increases. We included 2,161,908 participants and found that 49.4% of mothers were 30–34 years of age at delivery. The proportion of mothers aged 35 and above increased over the 5-year analysis period. A maternal age lower than 29 years or higher than 40 years was associated with a relatively higher risk of early neonatal mortality. The trend and magnitude of the age-related risk on early neonatal mortality were independent of maternal socioeconomic factors such as living in an obstetrically underserved area, education level, and employment status. Furthermore, we showed that the risk for early neonatal mortality was higher until the maternal age of 28. However, there were no significant changes in the risk between the age of 35 and 40 years. According to recent national-wide data, age-related risk for early neonatal mortality is only apparent for mothers ≥ 40 years old whereas, age between 35 and 39 are not at increased risk for early neonatal mortality, despite being classified as AMA.
format	article
author	Yoo-Na Kim Dong-Woo Choi Dong Seop Kim Eun-Cheol Park Ja-Young Kwon
author_facet	Yoo-Na Kim Dong-Woo Choi Dong Seop Kim Eun-Cheol Park Ja-Young Kwon
author_sort	Yoo-Na Kim
title	Maternal age and risk of early neonatal mortality: a national cohort study
title_short	Maternal age and risk of early neonatal mortality: a national cohort study
title_full	Maternal age and risk of early neonatal mortality: a national cohort study
title_fullStr	Maternal age and risk of early neonatal mortality: a national cohort study
title_full_unstemmed	Maternal age and risk of early neonatal mortality: a national cohort study
title_sort	maternal age and risk of early neonatal mortality: a national cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cc3930340a1a4d70b4e68f83cc77e021
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Maternal age and risk of early neonatal mortality: a national cohort study

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