Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

Traumatic brain injury (TBI) is a serious and poorly understood medical condition. Here, the authors show that TBI induces long-lasting deficits in brain lymphatic drainage. They report that defects in this drainage pathway provoke severe TBI pathogenesis that can be rescued with VEGF-C treatment.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ashley C. Bolte, Arun B. Dutta, Mariah E. Hurt, Igor Smirnov, Michael A. Kovacs, Celia A. McKee, Hannah E. Ennerfelt, Daniel Shapiro, Bao H. Nguyen, Elizabeth L. Frost, Catherine R. Lammert, Jonathan Kipnis, John R. Lukens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cc3b96a86db74fb2bb59bfc9050c1baa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cc3b96a86db74fb2bb59bfc9050c1baa
record_format	dspace
spelling	oai:doaj.org-article:cc3b96a86db74fb2bb59bfc9050c1baa2021-12-02T19:12:34ZMeningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis10.1038/s41467-020-18113-42041-1723https://doaj.org/article/cc3b96a86db74fb2bb59bfc9050c1baa2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18113-4https://doaj.org/toc/2041-1723Traumatic brain injury (TBI) is a serious and poorly understood medical condition. Here, the authors show that TBI induces long-lasting deficits in brain lymphatic drainage. They report that defects in this drainage pathway provoke severe TBI pathogenesis that can be rescued with VEGF-C treatment.Ashley C. BolteArun B. DuttaMariah E. HurtIgor SmirnovMichael A. KovacsCelia A. McKeeHannah E. EnnerfeltDaniel ShapiroBao H. NguyenElizabeth L. FrostCatherine R. LammertJonathan KipnisJohn R. LukensNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ashley C. Bolte Arun B. Dutta Mariah E. Hurt Igor Smirnov Michael A. Kovacs Celia A. McKee Hannah E. Ennerfelt Daniel Shapiro Bao H. Nguyen Elizabeth L. Frost Catherine R. Lammert Jonathan Kipnis John R. Lukens Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
description	Traumatic brain injury (TBI) is a serious and poorly understood medical condition. Here, the authors show that TBI induces long-lasting deficits in brain lymphatic drainage. They report that defects in this drainage pathway provoke severe TBI pathogenesis that can be rescued with VEGF-C treatment.
format	article
author	Ashley C. Bolte Arun B. Dutta Mariah E. Hurt Igor Smirnov Michael A. Kovacs Celia A. McKee Hannah E. Ennerfelt Daniel Shapiro Bao H. Nguyen Elizabeth L. Frost Catherine R. Lammert Jonathan Kipnis John R. Lukens
author_facet	Ashley C. Bolte Arun B. Dutta Mariah E. Hurt Igor Smirnov Michael A. Kovacs Celia A. McKee Hannah E. Ennerfelt Daniel Shapiro Bao H. Nguyen Elizabeth L. Frost Catherine R. Lammert Jonathan Kipnis John R. Lukens
author_sort	Ashley C. Bolte
title	Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
title_short	Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
title_full	Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
title_fullStr	Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
title_full_unstemmed	Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
title_sort	meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cc3b96a86db74fb2bb59bfc9050c1baa
work_keys_str_mv	AT ashleycbolte meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT arunbdutta meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT mariahehurt meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT igorsmirnov meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT michaelakovacs meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT celiaamckee meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT hannaheennerfelt meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT danielshapiro meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT baohnguyen meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT elizabethlfrost meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT catherinerlammert meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT jonathankipnis meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis AT johnrlukens meningeallymphaticdysfunctionexacerbatestraumaticbraininjurypathogenesis
_version_	1718377028571365376

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

Ejemplares similares