Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

Identifying the molecular mechanisms of response to systemic therapy in prostate cancer remains crucial. Here, the authors apply single cell-ATAC and RNAseq to models of early treatment response and resistance to enzalutamide and identify chromatin and gene expression patterns that can predict treat...

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Autores principales: S. Taavitsainen, N. Engedal, S. Cao, F. Handle, A. Erickson, S. Prekovic, D. Wetterskog, T. Tolonen, E. M. Vuorinen, A. Kiviaho, R. Nätkin, T. Häkkinen, W. Devlies, S. Henttinen, R. Kaarijärvi, M. Lahnalampi, H. Kaljunen, K. Nowakowska, H. Syvälä, M. Bläuer, P. Cremaschi, F. Claessens, T. Visakorpi, T. L. J. Tammela, T. Murtola, K. J. Granberg, A. D. Lamb, K. Ketola, I. G. Mills, G. Attard, W. Wang, M. Nykter, A. Urbanucci
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/cc3e718f606845d686441f42a30442e4
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spelling oai:doaj.org-article:cc3e718f606845d686441f42a30442e42021-12-02T14:54:28ZSingle-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse10.1038/s41467-021-25624-12041-1723https://doaj.org/article/cc3e718f606845d686441f42a30442e42021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25624-1https://doaj.org/toc/2041-1723Identifying the molecular mechanisms of response to systemic therapy in prostate cancer remains crucial. Here, the authors apply single cell-ATAC and RNAseq to models of early treatment response and resistance to enzalutamide and identify chromatin and gene expression patterns that can predict treatment response.S. TaavitsainenN. EngedalS. CaoF. HandleA. EricksonS. PrekovicD. WetterskogT. TolonenE. M. VuorinenA. KiviahoR. NätkinT. HäkkinenW. DevliesS. HenttinenR. KaarijärviM. LahnalampiH. KaljunenK. NowakowskaH. SyväläM. BläuerP. CremaschiF. ClaessensT. VisakorpiT. L. J. TammelaT. MurtolaK. J. GranbergA. D. LambK. KetolaI. G. MillsG. AttardW. WangM. NykterA. UrbanucciNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
S. Taavitsainen
N. Engedal
S. Cao
F. Handle
A. Erickson
S. Prekovic
D. Wetterskog
T. Tolonen
E. M. Vuorinen
A. Kiviaho
R. Nätkin
T. Häkkinen
W. Devlies
S. Henttinen
R. Kaarijärvi
M. Lahnalampi
H. Kaljunen
K. Nowakowska
H. Syvälä
M. Bläuer
P. Cremaschi
F. Claessens
T. Visakorpi
T. L. J. Tammela
T. Murtola
K. J. Granberg
A. D. Lamb
K. Ketola
I. G. Mills
G. Attard
W. Wang
M. Nykter
A. Urbanucci
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
description Identifying the molecular mechanisms of response to systemic therapy in prostate cancer remains crucial. Here, the authors apply single cell-ATAC and RNAseq to models of early treatment response and resistance to enzalutamide and identify chromatin and gene expression patterns that can predict treatment response.
format article
author S. Taavitsainen
N. Engedal
S. Cao
F. Handle
A. Erickson
S. Prekovic
D. Wetterskog
T. Tolonen
E. M. Vuorinen
A. Kiviaho
R. Nätkin
T. Häkkinen
W. Devlies
S. Henttinen
R. Kaarijärvi
M. Lahnalampi
H. Kaljunen
K. Nowakowska
H. Syvälä
M. Bläuer
P. Cremaschi
F. Claessens
T. Visakorpi
T. L. J. Tammela
T. Murtola
K. J. Granberg
A. D. Lamb
K. Ketola
I. G. Mills
G. Attard
W. Wang
M. Nykter
A. Urbanucci
author_facet S. Taavitsainen
N. Engedal
S. Cao
F. Handle
A. Erickson
S. Prekovic
D. Wetterskog
T. Tolonen
E. M. Vuorinen
A. Kiviaho
R. Nätkin
T. Häkkinen
W. Devlies
S. Henttinen
R. Kaarijärvi
M. Lahnalampi
H. Kaljunen
K. Nowakowska
H. Syvälä
M. Bläuer
P. Cremaschi
F. Claessens
T. Visakorpi
T. L. J. Tammela
T. Murtola
K. J. Granberg
A. D. Lamb
K. Ketola
I. G. Mills
G. Attard
W. Wang
M. Nykter
A. Urbanucci
author_sort S. Taavitsainen
title Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
title_short Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
title_full Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
title_fullStr Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
title_full_unstemmed Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
title_sort single-cell atac and rna sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/cc3e718f606845d686441f42a30442e4
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