Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.

<h4>Background</h4>3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole (DIC) is a five-membered heterocyclic compound containing a N-O bond. The anti-inflammatory effects of this compound were studied both in vitro and in vivo.<h4>Principal findings</h4>DIC effectively dec...

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Autores principales:	Amanda Roberta Revoredo Vicentino, Vitor Coutinho Carneiro, Anderson de Mendonça Amarante, Claudia Farias Benjamim, Alcino Palermo de Aguiar, Marcelo Rosado Fantappié
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc3ebbe876304ae3a9d92a69bcf1d226
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spelling	oai:doaj.org-article:cc3ebbe876304ae3a9d92a69bcf1d2262021-11-18T07:15:10ZEvaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.1932-620310.1371/journal.pone.0039104https://doaj.org/article/cc3ebbe876304ae3a9d92a69bcf1d2262012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22723938/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole (DIC) is a five-membered heterocyclic compound containing a N-O bond. The anti-inflammatory effects of this compound were studied both in vitro and in vivo.<h4>Principal findings</h4>DIC effectively decreased TNF-α and IL-6 release from LPS-stimulated macrophages in a dose dependent manner. DIC diminished the levels of COX-2 with subsequent inhibition of PGE(2) production. DIC also compromised HMGB1 translocation from the nucleus to the cytoplasm. Moreover, DIC prevented the nuclear translocation of NF-κB and inhibited the MAPK pathway. In vivo, DIC inhibited migration of neutrophils to the peritoneal cavity of mice.<h4>Conclusions</h4>This study presents the potential utilization of a synthetic compound, as a lead for the development of novel anti-inflammatory drugs.Amanda Roberta Revoredo VicentinoVitor Coutinho CarneiroAnderson de Mendonça AmaranteClaudia Farias BenjamimAlcino Palermo de AguiarMarcelo Rosado FantappiéPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39104 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amanda Roberta Revoredo Vicentino Vitor Coutinho Carneiro Anderson de Mendonça Amarante Claudia Farias Benjamim Alcino Palermo de Aguiar Marcelo Rosado Fantappié Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.
description	<h4>Background</h4>3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole (DIC) is a five-membered heterocyclic compound containing a N-O bond. The anti-inflammatory effects of this compound were studied both in vitro and in vivo.<h4>Principal findings</h4>DIC effectively decreased TNF-α and IL-6 release from LPS-stimulated macrophages in a dose dependent manner. DIC diminished the levels of COX-2 with subsequent inhibition of PGE(2) production. DIC also compromised HMGB1 translocation from the nucleus to the cytoplasm. Moreover, DIC prevented the nuclear translocation of NF-κB and inhibited the MAPK pathway. In vivo, DIC inhibited migration of neutrophils to the peritoneal cavity of mice.<h4>Conclusions</h4>This study presents the potential utilization of a synthetic compound, as a lead for the development of novel anti-inflammatory drugs.
format	article
author	Amanda Roberta Revoredo Vicentino Vitor Coutinho Carneiro Anderson de Mendonça Amarante Claudia Farias Benjamim Alcino Palermo de Aguiar Marcelo Rosado Fantappié
author_facet	Amanda Roberta Revoredo Vicentino Vitor Coutinho Carneiro Anderson de Mendonça Amarante Claudia Farias Benjamim Alcino Palermo de Aguiar Marcelo Rosado Fantappié
author_sort	Amanda Roberta Revoredo Vicentino
title	Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.
title_short	Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.
title_full	Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.
title_fullStr	Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.
title_full_unstemmed	Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.
title_sort	evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/cc3ebbe876304ae3a9d92a69bcf1d226
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Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.

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