Progranulin deficiency causes the retinal ganglion cell loss during development

Abstract Astrocytes are glial cells that support and protect neurons in the central nervous systems including the retina. Retinal ganglion cells (RGCs) are in contact with the astrocytes and our earlier findings showed the reduction of the number of cells in the ganglion cell layer in adult progranu...

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Autores principales:	Yoshiki Kuse, Kazuhiro Tsuruma, Takahiro Mizoguchi, Masamitsu Shimazawa, Hideaki Hara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cc40662e291b41acae416b8c7208f4c3
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spelling	oai:doaj.org-article:cc40662e291b41acae416b8c7208f4c32021-12-02T15:05:30ZProgranulin deficiency causes the retinal ganglion cell loss during development10.1038/s41598-017-01933-82045-2322https://doaj.org/article/cc40662e291b41acae416b8c7208f4c32017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01933-8https://doaj.org/toc/2045-2322Abstract Astrocytes are glial cells that support and protect neurons in the central nervous systems including the retina. Retinal ganglion cells (RGCs) are in contact with the astrocytes and our earlier findings showed the reduction of the number of cells in the ganglion cell layer in adult progranulin deficient mice. In the present study, we focused on the time of activation of the astrocytes and the alterations in the number of RGCs in the retina and optic nerve in progranulin deficient mice. Our findings showed that the number of Brn3a-positive cells was reduced and the expression of glial fibrillary acidic protein (GFAP) was increased in progranulin deficient mice. The progranulin deficient mice had a high expression of GFAP on postnatal day 9 (P9) but not on postnatal day 1. These mice also had a decrease in the number of the Brn3a-positive cells on P9. Taken together, these findings indicate that the absence of progranulin can affect the survival of RGCs subsequent the activation of astrocytes during retinal development.Yoshiki KuseKazuhiro TsurumaTakahiro MizoguchiMasamitsu ShimazawaHideaki HaraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshiki Kuse Kazuhiro Tsuruma Takahiro Mizoguchi Masamitsu Shimazawa Hideaki Hara Progranulin deficiency causes the retinal ganglion cell loss during development
description	Abstract Astrocytes are glial cells that support and protect neurons in the central nervous systems including the retina. Retinal ganglion cells (RGCs) are in contact with the astrocytes and our earlier findings showed the reduction of the number of cells in the ganglion cell layer in adult progranulin deficient mice. In the present study, we focused on the time of activation of the astrocytes and the alterations in the number of RGCs in the retina and optic nerve in progranulin deficient mice. Our findings showed that the number of Brn3a-positive cells was reduced and the expression of glial fibrillary acidic protein (GFAP) was increased in progranulin deficient mice. The progranulin deficient mice had a high expression of GFAP on postnatal day 9 (P9) but not on postnatal day 1. These mice also had a decrease in the number of the Brn3a-positive cells on P9. Taken together, these findings indicate that the absence of progranulin can affect the survival of RGCs subsequent the activation of astrocytes during retinal development.
format	article
author	Yoshiki Kuse Kazuhiro Tsuruma Takahiro Mizoguchi Masamitsu Shimazawa Hideaki Hara
author_facet	Yoshiki Kuse Kazuhiro Tsuruma Takahiro Mizoguchi Masamitsu Shimazawa Hideaki Hara
author_sort	Yoshiki Kuse
title	Progranulin deficiency causes the retinal ganglion cell loss during development
title_short	Progranulin deficiency causes the retinal ganglion cell loss during development
title_full	Progranulin deficiency causes the retinal ganglion cell loss during development
title_fullStr	Progranulin deficiency causes the retinal ganglion cell loss during development
title_full_unstemmed	Progranulin deficiency causes the retinal ganglion cell loss during development
title_sort	progranulin deficiency causes the retinal ganglion cell loss during development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cc40662e291b41acae416b8c7208f4c3
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_version_	1718388794610155520

Progranulin deficiency causes the retinal ganglion cell loss during development

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