Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer

The resistance that Triple-Negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, develops against radiotherapy is a complex phenomenon involving several regulators of cell metabolism and gene expression; understanding it is the only way to overcome it. We focused this review on t...

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Autores principales:	Alberto Aranza-Martínez, Julio Sánchez-Pérez, Luis Brito-Elias, César López-Camarillo, David Cantú de León, Carlos Pérez-Plasencia, Eduardo López-Urrutia
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	breast cancer triple negative breast-cancer radioresistance non-coding RNAs long non-coding RNAs microRNAs Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/cc41a306b8444638905c6ebc04cf6cf9
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spelling	oai:doaj.org-article:cc41a306b8444638905c6ebc04cf6cf92021-11-04T06:38:30ZNon-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer2234-943X10.3389/fonc.2021.752270https://doaj.org/article/cc41a306b8444638905c6ebc04cf6cf92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.752270/fullhttps://doaj.org/toc/2234-943XThe resistance that Triple-Negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, develops against radiotherapy is a complex phenomenon involving several regulators of cell metabolism and gene expression; understanding it is the only way to overcome it. We focused this review on the contribution of the two leading classes of regulatory non-coding RNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), against ionizing radiation-based therapies. We found that these regulatory RNAs are mainly associated with DNA damage response, cell death, and cell cycle regulation, although they regulate other processes like cell signaling and metabolism. Several regulatory RNAs regulate multiple pathways simultaneously, such as miR-139-5p, the miR-15 family, and the lncRNA HOTAIR. On the other hand, proteins such as CHK1 and WEE1 are targeted by several regulatory RNAs simultaneously. Interestingly, the study of miRNA/lncRNA/mRNA regulation axes increases, opening new avenues for understanding radioresistance. Many of the miRNAs and lncRNAs that we reviewed here can be used as molecular markers or targeted by upcoming therapeutic options, undoubtedly contributing to a better prognosis for TNBC patients.Alberto Aranza-MartínezJulio Sánchez-PérezLuis Brito-EliasCésar López-CamarilloDavid Cantú de LeónCarlos Pérez-PlasenciaCarlos Pérez-PlasenciaEduardo López-UrrutiaFrontiers Media S.A.articlebreast cancertriple negative breast-cancerradioresistancenon-coding RNAslong non-coding RNAsmicroRNAsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer triple negative breast-cancer radioresistance non-coding RNAs long non-coding RNAs microRNAs Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer triple negative breast-cancer radioresistance non-coding RNAs long non-coding RNAs microRNAs Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Alberto Aranza-Martínez Julio Sánchez-Pérez Luis Brito-Elias César López-Camarillo David Cantú de León Carlos Pérez-Plasencia Carlos Pérez-Plasencia Eduardo López-Urrutia Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer
description	The resistance that Triple-Negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, develops against radiotherapy is a complex phenomenon involving several regulators of cell metabolism and gene expression; understanding it is the only way to overcome it. We focused this review on the contribution of the two leading classes of regulatory non-coding RNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), against ionizing radiation-based therapies. We found that these regulatory RNAs are mainly associated with DNA damage response, cell death, and cell cycle regulation, although they regulate other processes like cell signaling and metabolism. Several regulatory RNAs regulate multiple pathways simultaneously, such as miR-139-5p, the miR-15 family, and the lncRNA HOTAIR. On the other hand, proteins such as CHK1 and WEE1 are targeted by several regulatory RNAs simultaneously. Interestingly, the study of miRNA/lncRNA/mRNA regulation axes increases, opening new avenues for understanding radioresistance. Many of the miRNAs and lncRNAs that we reviewed here can be used as molecular markers or targeted by upcoming therapeutic options, undoubtedly contributing to a better prognosis for TNBC patients.
format	article
author	Alberto Aranza-Martínez Julio Sánchez-Pérez Luis Brito-Elias César López-Camarillo David Cantú de León Carlos Pérez-Plasencia Carlos Pérez-Plasencia Eduardo López-Urrutia
author_facet	Alberto Aranza-Martínez Julio Sánchez-Pérez Luis Brito-Elias César López-Camarillo David Cantú de León Carlos Pérez-Plasencia Carlos Pérez-Plasencia Eduardo López-Urrutia
author_sort	Alberto Aranza-Martínez
title	Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer
title_short	Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer
title_full	Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer
title_fullStr	Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer
title_full_unstemmed	Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer
title_sort	non-coding rnas associated with radioresistance in triple-negative breast cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cc41a306b8444638905c6ebc04cf6cf9
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Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer

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