Targeting Tumor-Associated Macrophages in Cancer Immunotherapy

Tumor-associated macrophages (TAMs) represent the most abundant leukocyte population in most solid tumors and are greatly influenced by the tumor microenvironment. More importantly, these macrophages can promote tumor growth and metastasis through interactions with other cell populations within the...

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Autores principales:	Amy J. Petty, Dwight H. Owen, Yiping Yang, Xiaopei Huang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tumor-associated macrophages (TAM) tumor microenvironment immunotherapy checkpoint inhibitor cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/cc4260f365554db2a2b9811a54b63433
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spelling	oai:doaj.org-article:cc4260f365554db2a2b9811a54b634332021-11-11T15:28:15ZTargeting Tumor-Associated Macrophages in Cancer Immunotherapy10.3390/cancers132153182072-6694https://doaj.org/article/cc4260f365554db2a2b9811a54b634332021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5318https://doaj.org/toc/2072-6694Tumor-associated macrophages (TAMs) represent the most abundant leukocyte population in most solid tumors and are greatly influenced by the tumor microenvironment. More importantly, these macrophages can promote tumor growth and metastasis through interactions with other cell populations within the tumor milieu and have been associated with poor outcomes in multiple tumors. In this review, we examine how the tumor microenvironment facilitates the polarization of TAMs. Additionally, we evaluate the mechanisms by which TAMs promote tumor angiogenesis, induce tumor invasion and metastasis, enhance chemotherapeutic resistance, and foster immune evasion. Lastly, we focus on therapeutic strategies that target TAMs in the treatments of cancer, including reducing monocyte recruitment, depleting or reprogramming TAMs, and targeting inhibitory molecules to increase TAM-mediated phagocytosis.Amy J. PettyDwight H. OwenYiping YangXiaopei HuangMDPI AGarticletumor-associated macrophages (TAM)tumor microenvironmentimmunotherapycheckpoint inhibitorcancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5318, p 5318 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor-associated macrophages (TAM) tumor microenvironment immunotherapy checkpoint inhibitor cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	tumor-associated macrophages (TAM) tumor microenvironment immunotherapy checkpoint inhibitor cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Amy J. Petty Dwight H. Owen Yiping Yang Xiaopei Huang Targeting Tumor-Associated Macrophages in Cancer Immunotherapy
description	Tumor-associated macrophages (TAMs) represent the most abundant leukocyte population in most solid tumors and are greatly influenced by the tumor microenvironment. More importantly, these macrophages can promote tumor growth and metastasis through interactions with other cell populations within the tumor milieu and have been associated with poor outcomes in multiple tumors. In this review, we examine how the tumor microenvironment facilitates the polarization of TAMs. Additionally, we evaluate the mechanisms by which TAMs promote tumor angiogenesis, induce tumor invasion and metastasis, enhance chemotherapeutic resistance, and foster immune evasion. Lastly, we focus on therapeutic strategies that target TAMs in the treatments of cancer, including reducing monocyte recruitment, depleting or reprogramming TAMs, and targeting inhibitory molecules to increase TAM-mediated phagocytosis.
format	article
author	Amy J. Petty Dwight H. Owen Yiping Yang Xiaopei Huang
author_facet	Amy J. Petty Dwight H. Owen Yiping Yang Xiaopei Huang
author_sort	Amy J. Petty
title	Targeting Tumor-Associated Macrophages in Cancer Immunotherapy
title_short	Targeting Tumor-Associated Macrophages in Cancer Immunotherapy
title_full	Targeting Tumor-Associated Macrophages in Cancer Immunotherapy
title_fullStr	Targeting Tumor-Associated Macrophages in Cancer Immunotherapy
title_full_unstemmed	Targeting Tumor-Associated Macrophages in Cancer Immunotherapy
title_sort	targeting tumor-associated macrophages in cancer immunotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cc4260f365554db2a2b9811a54b63433
work_keys_str_mv	AT amyjpetty targetingtumorassociatedmacrophagesincancerimmunotherapy AT dwighthowen targetingtumorassociatedmacrophagesincancerimmunotherapy AT yipingyang targetingtumorassociatedmacrophagesincancerimmunotherapy AT xiaopeihuang targetingtumorassociatedmacrophagesincancerimmunotherapy
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Targeting Tumor-Associated Macrophages in Cancer Immunotherapy

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