Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy

Haiying Hua,1,* Nan Zhang,2,3,* Dan Liu,1 Lili Song,1 Tuanbing Liu,2,3 Shasha Li,2,3 Yongxing Zhao2,3 1Academy of Medical and Pharmaceutical Sciences, 2Department of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, 3Key Laboratory of Targeting Therapy and Diagnosis for Critic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hua H, Zhang N, Liu D, Song L, Liu T, Li S, Zhao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Gold nanorods Docetaxel Liposomes Prostate cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cc4abf392bed4dca8f8fa99a12b3649e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cc4abf392bed4dca8f8fa99a12b3649e
record_format	dspace
spelling	oai:doaj.org-article:cc4abf392bed4dca8f8fa99a12b3649e2021-12-02T07:13:45ZMultifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy1178-2013https://doaj.org/article/cc4abf392bed4dca8f8fa99a12b3649e2017-10-01T00:00:00Zhttps://www.dovepress.com/multifunctional-gold-nanorods-and-docetaxel-encapsulated-liposomes-for-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Haiying Hua,1,* Nan Zhang,2,3,* Dan Liu,1 Lili Song,1 Tuanbing Liu,2,3 Shasha Li,2,3 Yongxing Zhao2,3 1Academy of Medical and Pharmaceutical Sciences, 2Department of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, 3Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou, Henan, China *These authors contributed equally to this work Abstract: Personalized and precise nanomedicines are highly demanded for today’s medical needs. Liposomes are ideal candidates for the construction of multifunctional drug delivery systems. In this study, a liposome was used to improve the clinical issues of docetaxel (Doc), a potent antimitotic chemotherapy for prostate cancer (PC). RLT, a low-density lipoprotein receptor (LDLR)-binding peptide, and PEG were conjugated to the liposomes, and gold nanorods (GNRs) were also incorporated into the liposomes. The GNRs/Doc-liposome-RLT (GNRs/DocL-R) was tested in PC-3 cells and in PC-3 tumor-bearing nude mice. Results showed that GNRs/DocL-R possessed a diameter approximately 163.15±1.83 nm and a zeta potential approximately -32.8±2.16 mV. GNRs/DocL-R showed enhanced intracellular entrance, increased accumulation in the implanted tumor region, and the highest tumor inhibition in vitro and in vivo. Therefore, the multifunctional GNRs/DocL-R was a potential cancer treatment via combined chemo- and thermotherapy. Keywords: gold nanorods, docetaxel, liposomes, prostate cancer, LDL receptor targetingHua HZhang NLiu DSong LLiu TLi SZhao YDove Medical PressarticleGold nanorodsDocetaxelLiposomesProstate cancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7869-7884 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold nanorods Docetaxel Liposomes Prostate cancer Medicine (General) R5-920
spellingShingle	Gold nanorods Docetaxel Liposomes Prostate cancer Medicine (General) R5-920 Hua H Zhang N Liu D Song L Liu T Li S Zhao Y Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy
description	Haiying Hua,1,* Nan Zhang,2,3,* Dan Liu,1 Lili Song,1 Tuanbing Liu,2,3 Shasha Li,2,3 Yongxing Zhao2,3 1Academy of Medical and Pharmaceutical Sciences, 2Department of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, 3Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou, Henan, China *These authors contributed equally to this work Abstract: Personalized and precise nanomedicines are highly demanded for today’s medical needs. Liposomes are ideal candidates for the construction of multifunctional drug delivery systems. In this study, a liposome was used to improve the clinical issues of docetaxel (Doc), a potent antimitotic chemotherapy for prostate cancer (PC). RLT, a low-density lipoprotein receptor (LDLR)-binding peptide, and PEG were conjugated to the liposomes, and gold nanorods (GNRs) were also incorporated into the liposomes. The GNRs/Doc-liposome-RLT (GNRs/DocL-R) was tested in PC-3 cells and in PC-3 tumor-bearing nude mice. Results showed that GNRs/DocL-R possessed a diameter approximately 163.15±1.83 nm and a zeta potential approximately -32.8±2.16 mV. GNRs/DocL-R showed enhanced intracellular entrance, increased accumulation in the implanted tumor region, and the highest tumor inhibition in vitro and in vivo. Therefore, the multifunctional GNRs/DocL-R was a potential cancer treatment via combined chemo- and thermotherapy. Keywords: gold nanorods, docetaxel, liposomes, prostate cancer, LDL receptor targeting
format	article
author	Hua H Zhang N Liu D Song L Liu T Li S Zhao Y
author_facet	Hua H Zhang N Liu D Song L Liu T Li S Zhao Y
author_sort	Hua H
title	Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy
title_short	Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy
title_full	Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy
title_fullStr	Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy
title_full_unstemmed	Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy
title_sort	multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/cc4abf392bed4dca8f8fa99a12b3649e
work_keys_str_mv	AT huah multifunctionalgoldnanorodsanddocetaxelencapsulatedliposomesforcombinedthermoandchemotherapy AT zhangn multifunctionalgoldnanorodsanddocetaxelencapsulatedliposomesforcombinedthermoandchemotherapy AT liud multifunctionalgoldnanorodsanddocetaxelencapsulatedliposomesforcombinedthermoandchemotherapy AT songl multifunctionalgoldnanorodsanddocetaxelencapsulatedliposomesforcombinedthermoandchemotherapy AT liut multifunctionalgoldnanorodsanddocetaxelencapsulatedliposomesforcombinedthermoandchemotherapy AT lis multifunctionalgoldnanorodsanddocetaxelencapsulatedliposomesforcombinedthermoandchemotherapy AT zhaoy multifunctionalgoldnanorodsanddocetaxelencapsulatedliposomesforcombinedthermoandchemotherapy
_version_	1718399542464872448

Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy

Ejemplares similares